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PHENERGAN® Preparations Novartis Consumer Health Promethazine HCl Antihistamine Action And Clinical Pharmacology: Promethazine is an antihistamine with sedative, antiemetic and antispasmodic properties. In addition, it exerts local anesthetic effects and potentiates analgesics, anesthetics and other CNS depressants. Indications And Clinical Uses: Allergic reactions: hay fever, urticaria, vasomotor rhinitis, skin allergies, poison ivy, insect bites; for the relief of pruritus due to various dermatologic conditions. Nausea and vomiting of various etiologies:…

PHENERGAN® Injectable Rhône-Poulenc Rorer Promethazine HCl Antihistamine Action And Clinical Pharmacology: Promethazine is an antihistamine with sedative, antiemetic and antispasmodic properties. In addition, it exerts local anesthetic effects and potentiates analgesics, anesthetics and other CNS depressants. Indications And Clinical Uses: Allergic reactions: hay fever, urticaria, vasomotor rhinitis, skin allergies, poison ivy, insect bites; for the relief of pruritus due to various dermatologic conditions. Nausea and vomiting of various etiologies: motion…

PHENYTOIN General Monograph, Diphenylhydantoin Anticonvulsant Action And Clinical Pharmacology: Phenytoin is an anticonvulsant which elevates the seizure threshold in the motor cortex by limiting the post-tetanic potentiation (PTP) of synaptic transmission. It exerts this effect by preventing the excessive accumulation of intracellular sodium during tetanic stimulation by either reducing the passive influx of sodium or increasing the efficiency of the sodium pump. By limiting PTP, phenytoin prevents the spread of…

PERSANTINE® Boehringer Ingelheim Dipyridamole Coronary Vasodilator – Inhibitor of Platelet Adhesion and Aggregation Action And Clinical Pharmacology: Dipyridamole normalizes increased platelet adhesiveness and tendency to aggregate (Hellem’s method). Dipyridamole has been found to lengthen abnormally shortened platelet survival time in a dose-dependent manner; 400 mg/day or 100 mg/day plus 1 g ASA. It is believed that platelet reactivity and interaction with prosthetic cardiac valve surfaces, resulting in abnormal shortened platelet…

PETHIDINE INJECTION BP Faulding Meperidine HCl Opioid Analgesic Action And Clinical Pharmacology: Meperidine is a narcotic analgesic with multiple actions qualitatively similar to those of morphine. The most prominent of these actions involve the CNS and organs which are composed of smooth muscle. Analgesia and sedation are the principal actions of therapeutic value. Some evidence suggests that meperidine may produce less smooth muscle spasm, constipation, and depression of the cough…

PHARMORUBICIN® Pharmacia & Upjohn Epirubicin HCl Antineoplastic Action And Clinical Pharmacology: The mechanism of action of epirubicin, although not completely elucidated, is mainly related to its ability to bind to nucleic acids by intercalation of the planar anthracycline nucleus with the DNA double helix. Binding to cell membranes as well as to plasma proteins may also be involved. Cell culture studies have demonstrated rapid cell penetration and perinucleolar chromatin binding,…

PHAZYME™ Preparations R & C Simethicone Antiflatulent Indications And Clinical Uses: For relief of discomfort due to gastrointestinal gas, resulting from aerophagia, dyspepsia. Also, for relief of gas distress associated with other functional or organic conditions such as: diverticulosis, spastic colon, hyperacidity, postcholecystectomy syndrome, chronic cholecystitis, chronic pancreatitis, chronic alcoholism, elevated diaphragm in late pregnancy, aerophagia and aerophagic pseudoangina. Dosage And Administration: Phazyme-95: 1 softgel before meals and at bedtime….

PERI-COLACE® Roberts Docusate Sodium – Casanthranol Laxative – Stool Softener Indications And Clinical Uses: Occasional or temporary constipation. Contra-Indications: When symptoms of appendicitis or intestinal obstruction are present. Precautions: Do not use in presence of abdominal pain, nausea, fever or vomiting. Use with caution in lactating women as the compound may cause increased stooling in the infant. Frequent or prolonged use may result in dependence on laxatives. Do not administer…

PERIACTIN® Johnson & Johnson Merck Cyproheptadine HCl Antihistaminic Action And Clinical Pharmacology: Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects recommended for the symptomatic treatment of allergic disorders and pruritic dermatoses, as well as certain types of vascular headaches. Indications And Clinical Uses: Cyproheptadine has a wide range of antiallergic and antipruritic activity and can be used successfully in the treatment of acute and chronic allergies…

PERIDEX® Zila Pharmaceuticals Chlorhexidine Gluconate Antigingivitis Action And Clinical Pharmacology: Chlorhexidine provides antimicrobial activity during oral rinsing which is maintained between rinsings. Microbiologic sampling of plaque has shown a general reduction of both aerobic and anaerobic bacterial counts ranging from 54 to 97% through 6 months’ clinical use. Rinsing with chlorhexidine inhibits the buildup and maturation of plaque by reducing certain microbes regarded as gingival pathogens, thereby reducing gingivitis. Chlorhexidine…