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PERMAX® Draxis Health Pergolide Mesylate Dopamine Agonist Action And Clinical Pharmacology: Pergolide mesylate, a synthetic ergot derivative, is a dopamine receptor agonist at both D1 and D2 receptor sites. In Parkinson’s disease, pergolide is believed to exert its therapeutic effect by directly stimulating postsynaptic dopamine receptors in the corpus striatum. In addition, pergolide suppresses the secretion of prolactin, causes a transient increase in serum concentration of growth hormone and a…

PEPTOL® Carter Horner Cimetidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Cimetidine inhibits competitively the action of histamine at the histamine H2 receptor and it is not an anticholinergic agent. It inhibits both daytime and nocturnal basal gastric acid secretion. Similarly, gastric acid secretion stimulated by food, histamine, pentagastrin, insulin and caffeine is inhibited by cimetidine. After oral administration, cimetidine is absorbed rapidly. The plasma half-life is about 2…

PERCOCET® PERCOCET®-DEMI DuPont Pharma Oxycodone HCl – Acetaminophen Opioid Analgesic Action And Clinical Pharmacology: The principal ingredient, oxycodone, is a semisynthetic opioid analgesic with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the CNS and organs composed of smooth muscle. The principal actions of therapeutic value of the oxycodone in Percocet are analgesia and sedation. Oxycodone is similar to codeine and methadone in that…

PERGONAL® Serono Menotropins Gonadotropins Action And Clinical Pharmacology: Menotropins is a purified preparation of gonadotropins extracted from the urine of postmenopausal women. Indications And Clinical Uses: Women: Menotropins and human chorionic gonadotropin (hCG) given in a sequential manner are indicated for the induction of ovulation and to enable pregnancy in the anovulatory infertile patient, in whom the cause of anovulation is functional and is not due to primary ovarian failure….

PERCODAN® PERCODAN®-DEMI DuPont Pharma Oxycodone HCl – ASA Opioid Analgesic Action And Clinical Pharmacology: The principal ingredient, oxycodone, is a semisynthetic opioid analgesic with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the CNS and organs composed of smooth muscle. The principal actions of therapeutic value of the oxycodone in Percodan are analgesia and sedation. Oxycodone is similar to codeine and methadone in that…

PENTASPAN® DuPont Pharma Pentastarch Plasma Volume Expander Action And Clinical Pharmacology: The colloidal properties of pentastarch render it useful as a plasma volume expander. I.V. infusion of pentastarch results in expansion of the plasma volume in excess of the volume infused. This expansion persists for approximately 18 to 24 hours and is expected to improve the hemodynamic status for 12 to 18 hours. Pentastarch molecules below 50 000 molecular weight…

PENTOTHAL® Abbott Thiopental Sodium I.V. Anesthetic Indications And Clinical Uses: As the sole anesthetic agent for brief (15-minute) procedures; for induction of anesthesia prior to administration of other anesthetic agents; to supplement regional anesthesia; to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation; for the control of convulsive states during or following inhalation anesthesia, local anesthesia, or other causes; in neurosurgical patients with increased intracranial…

PEPCID AC® Johnson & Johnsonheart• Merck Famotidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Famotidine is a competitive inhibitor of histamine H2-receptors. The primary clinically important pharmacologic activity of famotidine is inhibition of gastric juice secretion. Famotidine reduces the acid and pepsin content, as well as the volume, of basal, nocturnal, and stimulated gastric secretion. Pharmacokinetics: Famotidine is incompletely absorbed. The bioavailability of oral doses is 40 to 45%….

PEPCID® PEPCID® I.V. MSD Famotidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Famotidine is a competitive inhibitor of histamine H2-receptors. The primary clinically important pharmacologic activity is inhibition of gastric juice secretion. Famotidine reduces the acid and pepsin content, as well as the volume, of basal, nocturnal, and stimulated gastric secretion. In both normal volunteers and hypersecretors, famotidine inhibited basal nocturnal and daytime gastric secretion, as well as secretion…

PENTASA® Hoechst Marion Roussel 5-Aminosalicylic Acid Gastrointestinal Anti-inflammatory Action And Clinical Pharmacology: Pentasa is a unique, ethylcellulose-coated, delayed-release formulation of 5-ASA, an aminosalicylate, gastrointestinal anti-inflammatory agent for oral administration. Aminosalicylates are considered to be first line therapy for inflammatory bowel diseases. 5-ASA is known to be therapeutically active in Crohn’s disease and ulcerative colitis. Although the mechanism of action of 5-ASA is unknown, its therapeutic effect appears to be nonsystemic….