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SURVANTA® Abbott Beractant Lung Surfactant Action and Clinical Deficiency of pulmonary surfactant is an important factor in the development of Respiratory Distress Syndrome (RDS) in premature infants. Beractant replenishes surfactant and restores surface activity to the lungs of these infants. It reduces surface tension and concomitantly increases lung compliance.: Intratracheally administered beractant distributes rapidly to the alveolar surfaces and stabilizes the alveoli against collapse during respiration thereby increasing alveolar ventilation….

SUPREFACT® SUPREFACT® DEPOT Hoechst Marion Roussel Buserelin Acetate Luteinizing Hormone Releasing Hormone (LH-RH) Analog Action and Clinical Buserelin is a synthetic peptide analog of the natural gonadotropin releasing hormone (GnRH/LHRH). The substitution of glycine in position 6 by D-serine, and that of glycinamide in position 10 by ethylamide, leads to a nonapeptide with a greatly enhanced LHRH effect. The effects of buserelin on follicle stimulating hormone (FSH) and luteinizing hormone…

SUPREFACT® SUPREFACT® DEPOT Hoechst Marion Roussel Buserelin Acetate Luteinizing Hormone-Releasing Hormone (LH-RH) Analog Action and Clinical Buserelin is a synthetic peptide analog of the natural gonadotropin releasing hormone (GnRH/LHRH). The substitution of glycine in position 6 by D-serine, and that of glycinamide in position 10 by ethylamide, leads to a nonapeptide with a greatly enhanced LHRH effect. The effects of buserelin on follicle stimulating hormone (FSH) and luteinizing hormone (LH)…

SURGAM® SURGAM® SR Hoechst Marion Roussel Tiaprofenic Acid Anti-inflammatory Analgesic Action and Clinical Tiaprofenic acid, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. Its mechanism of action, as with other nonsteroidal anti-inflammatory agents, is not yet completely known. Tiaprofenic acid is an inhibitor of prostaglandin synthetase enzymes which are known to be associated with inflammation and pain. The therapeutic effect of tiaprofenic acid does not…

SUPRES® Merck Frosst Methyldopa-Chlorothiazide Antihypertensive Action and Clinical Methyldopa: Methyldopa, an antihypertensive agent, is an aromatic-amino-acid decarboxylase inhibitor in animals and in man. Although the mechanism of action has yet to be conclusively demonstrated, the antihypertensive effect of methyldopa probably is due to its metabolism to alpha-methyl-norepinephrine, which then lowers arterial pressure by stimulation of central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction of plasma renin activity. Methyldopa has been…

SULTRIN® Janssen-Ortho Triple Sulfa Vaginitis Therapy Indications And Clinical Uses: Postoperative vaginitis or cervicitis, nonspecific vaginitis, ulcerative vaginitis and related gynecological conditions. Contra-Indications: Sulfonamide sensitivity; kidney disease. Precautions: Although some absorption of sulfonamide may occur through the vaginal mucosa, systemic reactions attributable to this are infrequent, as are local sensitivity reactions such as increased discomfort or a burning sensation following the use of this product. However, as with all sulfonamides,…

SUPLASYN® Paladin Sodium Hyaluronate Synovial Fluid Replacement Action and Clinical Hyaluronic acid is a naturally occurring mucopolysaccharide present in the connective tissue of all animals. It is a biological polymer composed of repeating units of two sugars, D-glucuronic acid and N-acetylglycosamine, linked by glycosidic bonds. This configuration for hyaluronic acid is the same for all living species from bacteria to man. High concentrations are found in synovial fluid, the vitreous…

SUPRAX® Rhône-Poulenc Rorer Cefixime Antibiotic Action and Clinical Pharmacology: Cefixime exerts its bactericidal effect by attaching to penicillin-binding proteins and inhibiting peptidoglycan synthesis, thus causing damage to the bacterial cell wall.: Pharmacokinetics: Following oral dosing, cefixime attains peak serum levels in approximately 4 hours. The half-life is about 3 to 4 hours and is not dose dependent. Cefixime is excreted by renal and biliary mechanisms. About 50% of the absorbed dose is excreted…

SUPRANE® AstraZeneca Desflurane Inhalation Anesthetic Action and Clinical Pharmacology: Desflurane is a volatile inhalational anesthetic whose low solubility (blood/gas partition coefficient equals 0.42) permits rapid variation in anesthetic depth. If anesthesia is maintained with inflow rates of greater than 2 L/min, the alveolar concentration is usually within 10% of the inspired concentration. It is not necessary to deliver concentrations of desflurane far in excess of the desired end-tidal concentration (“overpressurization”…

SULCRATE® SUSPENSION PLUS Hoechst Marion Roussel Sucralfate Gastroduodenal Cytoprotective Agent Action and Clinical Pharmacology: Sucralfate exerts a generalized gastric cytoprotective effect by enhancing natural mucosal defense mechanisms. Studies conducted in animals and clinical trials in humans have demonstrated that sucralfate can protect the gastric mucosa against various irritants such as alcohol, ASA, hydrochloric acid, sodium hydroxide or sodium taurocholate. In addition, sucralfate has been demonstrated to have a greater affinity…