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TRUSOPT® Merck Frosst Dorzolamide HCl Elevated Intraocular Pressure Therapy–Topical Carbonic Anhydrase Inhibitor Action and Clinical Dorzolamide is a carbonic anhydrase inhibitor formulated for topical ophthalmic use. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure (IOP). Unlike oral carbonic anhydrase…

TRYPTAN™ ICN L-Tryptophan Adjunct in the Management of Affective Disorders Action and Clinical The rationale for the use of L-tryptophan in affective disorders is based on clinical findings more than 20 years ago, that L-tryptophan increases 5-HT (serotonin) synthesis in the CNS of humans. It has been demonstrated in clinical trials that oral ingestion of L-tryptophan in humans caused a significant increase in the level of the serotonin metabolite, 5-hydroxyindoleacetic…

TRIPTIL® Merck Frosst Protriptyline HCl Antidepressant Indications And Clinical Uses: In the treatment of depression that is a manifestation of psychosis or neurosis, whether endogenous or reactive in nature. Endogenous depression is more likely to respond than other depressive states. It is especially recommended for apathetic, withdrawn patients because it promptly relieves anergia and lacks sedative activity. These qualities make it useful also in ambulatory depressed patients. When used in…

TRISORALEN™ ICN Trioxsalen Melanizing Agent Action And Clinical Pharmacology: Trioxsalen is a synthetic melanizing agent structurally and pharmacologically related to methoxsalen. The normal pigmentation of the skin is due to melanin, which is produced in the cytoplasm of the melanocytes located in the basal layers of the epidermis at its junction with the dermis. Melanin is formed by the oxidation of tyrosine to DOPA (dihydroxyphenylalanine) with tyrosinase as catalyst. This…

TRISULFAMINIC Shepherd Triple Sulfas–Phenylpropanolamine HCl Compound–Pheniramine Maleate Decongestant–Antibacterial Indications And Clinical Uses: Congestion and infection of upper respiratory tract caused by sulfa-susceptible organisms. Contra-Indications: Sensitivity to any of the components, impaired renal function, pregnancy approaching term, and in premature infants and newborn infants during the first month of life. Do not use in patients with glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal or bladder neck obstruction or patients receiving MAO…

TROMBOVAR® Therapex Sodium Tetradecyl Sulfate Sclerosing Agent Indications And Clinical Uses: Sclerosing treatment of varicose veins in the legs, using compression sclerotherapy. Contra-Indications: Incompetency of collateral deep veins in the legs; incompetency of the valves of the greater and lesser saphenous veins before ligation of those veins; thrombophlebitis, tuberculosis and hyperthyroidism, acute infections, prolonged recumbency; cardiac insufficiency, diabetes, arterial disease, varicosities caused by pelvic neoplasia, pregnancy. Hypersensitivity to sodium tetradecyl…

TRILISATE® Purdue Frederick Choline Magnesium Trisalicylate Anti-inflammatory–Analgesic Action and Clinical Choline magnesium trisalicylate is a combination of choline salicylate and magnesium salicylate. Choline magnesium trisalicylate is a nonsteroidal anti-inflammatory drug (NSAID) which possesses the anti-inflammatory, analgesic and antipyretic activities characteristic of salicylates. It is, however, longer acting than acetylsalicylic acid and is less likely to cause gastrointestinal bleeding. In clinical trials 6 Trilisate tablets (containing 3 g of salicylate) showed…

TRINALIN® Schering Azatadine Maleate–Pseudoephedrine Sulfate Antihistamine–Decongestant Action and Clinical Azatadine is an antihistamine, related to cyproheptadine, with antiserotonin, anticholinergic, and sedative effects. Antihistamines appear to compete with histamine for histamine H1-receptor sites on effector cells and antagonize the vasodilator effect of endogenously released histamine. Consequently antihistamines antagonize the physiological manifestations of histamine release in the nose following antigen-antibody interaction, such as congestion related to vascular engorgement, mucosal edema, and profuse,…

TRINIPATCH® 0.2 TRINIPATCH® 0.4 TRINIPATCH® 0.6 Sanofi-Synthelabo Nitroglycerin Transdermal Delivery System Antianginal Action and Clinical The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle, producing a vasodilator effect on both peripheral arteries and veins, with more prominent effects on the latter. Dilation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure…

TRINIPATCH® 0.2 TRINIPATCH® 0.4 TRINIPATCH® 0.6 Sanofi-Synthelabo Nitroglycerin Transdermal Delivery System Antianginal Action and Clinical The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle, producing a vasodilator effect on both peripheral arteries and veins, with more prominent effects on the latter. Dilation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure…