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MINESTRIN™ 1/20 Parke-Davis Norethindrone Acetate – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Minestrin 1/20 achieves its contraceptive effect primarily by inhibition of ovulation through gonadotrophin suppression. It is well-established that oral contraceptives containing estrogen and progestogen affect hypothalamic, pituitary and ovarian functions. They may alter many other physiological systems. Although the exact mechanisms of action are incompletely understood, there is universal agreement that the inhibition of the ovulatory…

MINITRAN™ 3M Pharmaceuticals Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle and consequent dilation of both peripheral arteries and veins, with more prominent effects on the latter. Dilation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure (preload). Arteriolar relaxation reduces systemic vascular resistance…

Introduction Minocin is a tetracycline antibiotic used to treat various bacterial infections, such as urinary tract infections, severe acne, tick fever, chlamydia, gonorrhea, etc. Action And Clinical Pharmacology Minocycline is a tetracycline with antibacterial activity against some Gram-negative and Gram-positive organisms. The action is primarily bacteriostatic and it is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Indications And Clinical Uses Infections due to susceptible strains…

MINTEZOL® MSD Thiabendazole Anthelmintic Action And Clinical Pharmacology: Thiabendazole is an anthelmintic for the treatment of various nematode infections of man. Thiabendazole provides systemic treatment for cutaneous larva migrans. It causes worms to be eliminated spontaneously from the cutaneous blister or it eases their manual removal. In some instances the devitalized worm is not expelled and encystment with lysis occurs. In some patients, the drug has been useful in the…

MIOCHOL®-E CIBA Vision Acetylcholine Chloride – Electrolytes Miotic Action And Clinical Pharmacology: Acetylcholine is a naturally occurring neurohormone which mediates nerve impulse transmission at all cholinergic sites involving somatic and autonomic nerves. After release from the nerve ending, acetylcholine is rapidly inactivated by the enzyme acetylcholinesterase by hydrolysis to acetic acid and choline. Direct application of acetylcholine to the iris will cause rapid miosis of short duration. Topical ocular instillation…

MIGRANAL® Novartis Pharmaceuticals Dihydroergotamine Mesylate Migraine Therapy Action And Clinical Pharmacology: Dihydroergotamine displays agonist activity at the 5-HT1D receptor, which, by reducing 5-HT neuronal function and/or contracting elements of the cranial vasculature and/or suppressing neurogenic inflammation, is believed to underlie its antimigraine efficacy. It also displays affinity for the 5-HT1C receptor and antagonistic activity at the 5-HT2 subtype. Dihydroergotamine displays blocking actions at alpha adrenoreceptors, with a direct stimulating effect…

MIN-OVRAL® 21 MIN-OVRAL® 28 Wyeth-Ayerst Levonorgestrel – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Although the primary mechanism of action is inhibition of ovulation, the effectiveness of Min-Ovral may also result from other mechanisms of action, such as hostility of the cervical mucus to sperm penetration and migration. Indications And Clinical Uses: Conception control. Contra-Indications: History of/or actual thrombophlebitis or thromboembolic disorders; history of/or actual cerebrovascular disorders; history of/or…

MICROLAX® Pharmacia & Upjohn Micro-Enema Indications And Clinical Uses: Rectal constipation; or, as directed by a physician, to facilitate rectoscopic or sigmoidoscopic examination. Adverse Reactions: No severe reactions have been reported. Very occasionally slight cramps or tenesmus may occur. Dosage: Adults and children: the contents of 1 tube (5 mL) administered rectally but a second tube may be needed in severe cases; children under 3 years, insert only half the…

MICRO-K EXTENCAPS® MICRO-K-10 EXTENCAPS® Wyeth-Ayerst Microencapsulated Potassium Chloride Potassium Supplement Action And Clinical Pharmacology: Potassium ions participate in a number of physiological processes including the maintenance of intracellular tonicity; the transmission of nerve impulses; the contraction of cardiac, skeletal and smooth muscle; and the maintenance of normal renal function. Depletion may occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate…

MIDAMOR® MSD Amiloride HCl Antikaliuretic – Diuretic Action And Clinical Pharmacology: Amiloride is an antikaliuretic drug with mild natriuretic diuretic and antihypertensive activity. The activities may be additive to the effects of thiazides or other saluretic-diuretic agents. The principal use is to conserve potassium in selected patients receiving kaliuretic-diuretic agents. Amiloride interferes with the mechanism involved in the exchange of sodium for potassium in the distal convoluted tubule and collecting…