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MORPHINE SULFATE INJECTION BP (1 mg/mL and 2 mg/mL) Faulding Opioid Analgesic Action And Clinical Pharmacology: Morphine exerts its main actions by acting as an agonist at specific receptor sites in the CNS. Morphine produces many effects including analgesia, decreased gastrointestinal motility, respiratory depression, nausea, vomiting, drowsiness, changes in mood and alterations of the endocrine and autonomic nervous systems. Maximum analgesia occurs within 50 to 90 minutes after s.c. administration,…

MoRu-Viraten BERNA™ Berna Products Measles and Rubella Virus Vaccine, Live, Attenuated Active Immunizing Agent Action And Clinical Pharmacology: MoRu-Viraten Berna is a live virus vaccine for immunization against measles (rubeola) and rubella (German measles). A single dose of MoRu-Viraten Berna vaccine was administered to 26 children, 15 months to 9 years of age, who were seronegative [a rubella hemagglutination-inhibition (HI) titer of 256). The viral vaccine strains that comprise MoRu-Viraten…

MOTILIUM® Janssen-Ortho Domperidone Maleate Upper Gastrointestinal Motility Modifier Action And Clinical Pharmacology: Domperidone is a peripheral dopamine antagonist structurally related to the butyrophenones with antiemetic and gastroprokinetic properties. Domperidone effectively increases esophageal peristalsis and lower esophageal sphincter pressure (LESP), increases gastric motility and peristalsis, enhances gastroduodenal coordination and consequently facilitates gastric emptying and decreases small bowel transit time. The mechanism of action of domperidone is related to its peripheral dopamine…

Motrin (Children’s) McNeil Consumer Products Ibuprofen Analgesic – Antipyretic Action And Clinical Pharmacology: Ibuprofen is a member of the class of agents commonly known as nonsteroidal anti-inflammatory drugs (NSAIDs). Consistent with this classification, ibuprofen exhibits anti-inflammatory activity at higher dosage ranges. At lower adult single doses (200 to 400 mg) relevant to the nonprescription analgesic/antipyretic indications and dosage strength, ibuprofen relieves pain of mild to moderate intensity and reduces fever….

MONISTAT® 7 Cream MONISTAT 7 Vaginal Suppositories MONISTAT® 7 DUAL-PAK® Package (Also known as Combination Packs) MONISTAT® DERM Cream MONISTAT® 3 DUAL-PAK® Package (Also known as Combination Packs) MONISTAT® 3 Vaginal Ovules McNeil Consumer Products Miconazole Nitrate Antifungal Action And Clinical Pharmacology: Depending upon concentration, miconazole exhibits broad spectrum in vitro fungistatic or fungicidal activity against species of the genus Candida. Miconazole also inhibits several other genera of fungi, including…

MONITAN® Wyeth-Ayerst Acebutolol HCl Antihypertensive – Antianginal Agent Action And Clinical Pharmacology: Acebutolol is a beta-adrenergic receptor blocking agent. In vitro and in vivo animal studies have shown that it has a preferential effect on beta1-adrenoreceptors, chiefly located in cardiac muscle. This preferential effect is not absolute, however, and at higher doses acebutolol also inhibits beta2-adrenoreceptors, chiefly located in the bronchial and vascular musculature. It possesses some partial agonist activity…

MONOPRIL™ Bristol-Myers Squibb Fosinopril Sodium Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Fosinopril is an angiotensin converting enzyme (ACE) inhibitor which is used in the treatment of mild to moderate essential hypertension and in the management of symptomatic congestive heart failure. Following oral administration, fosinopril is rapidly hydrolyzed to fosinoprilat, its principal active metabolite. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor…

MODULON® Axcan Pharma Trimebutine Maleate Lower Gastrointestinal Tract Motility Regulator Action And Clinical Pharmacology: Trimebutine is a noncompetitive spasmolytic agent. It possesses moderate opiate receptor affinity and has a marked antiserotonin activity especially on “mu” receptors. It induces regulation of spontaneous activity and increases synchronization between electrophysiological spikes and contractions in isolated guinea pig taenia coli and ileum. However, it does not alter normal motility, but regulates abnormal intestinal activity….

MODURET® MSD Hydrochlorothiazide – Amiloride HCl Diuretic – Antihypertensive Action And Clinical Pharmacology: Moduret is a diuretic/antihypertensive combining the potent natriuretic action of hydrochlorothiazide with the potassium conserving property of amiloride. The mild diuretic and antihypertensive actions of amiloride are additive to the natriuretic, diuretic and antihypertensive activity of the thiazide while minimizing the loss of potassium and lessening the likelihood of acid base imbalance. The onset of the diuretic…

MOGADON® Roche Nitrazepam Hypnotic – Anticonvulsant Action And Clinical Pharmacology: Nitrazepam is a benzodiazepine with hypnotic and anticonvulsant properties. In sleep laboratory studies, nitrazepam decreased sleep latency, increased total sleep time and decreased awake time. There is delay in the onset, and decrease in the duration of REM sleep. Nitrazepam is reported to significantly decrease stage 1, 3 and 4 sleep and to increase stage 2. Following discontinuation of the…