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METHYLPREDNISOLONE SODIUM SUCCINATE FOR INJECTION USP Faulding Glucocorticoid – Anti-inflammatory Action And Clinical Pharmacology: Methylprednisolone is a synthetic adrenocortical steroid derivative with predominantly glucocorticoid properties possessing anti-inflammatory and immunosuppressive action. Methylprednisolone belongs to the pharmacologic class of glucocorticoid/anti-inflammatory drugs which, following systemic absorption, diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes may enter the cell nucleus, bind to DNA and stimulate transcription of mRNA. Subsequent cellular…

METIMYD® Schering Prednisolone – Sulfacetamide Compound Ophthalmic Corticosteroid – Antibacterial Indications And Clinical Uses: Inflammatory and allergic disease of the eye especially when antibacterial effect is desired. Contra-Indications: Tuberculosis, fungal and most viral lesions of the eye (herpes simplex/dendritic keratitis): vaccinia; varicella; acute purulent conjunctivitis and acute purulent blepharitis and in those persons who have shown hypersensitivity to any of its components. Precautions: Extended use of topical steroid therapy may…

MESTINON® MESTINON®-SR ICN Pyridostigmine Bromide Antimyasthenic – Cholinergic Action And Clinical Pharmacology: Pyridostigmine is a cholinergic agent which acts primarily by the inhibition of cholinesterase. It enhances cholinergic action by facilitating the transmission of impulses across neuromuscular junctions. It also has a direct cholinomimetic effect on skeletal muscle and possibly on autonomic ganglion cells and neurons of the CNS. Because of its quaternary ammonium structure, moderate doses of pyridostigmine do…

METANDREN® Novartis Methyltestosterone Oral Androgen Indications And Clinical Uses: In the male: replacement therapy in hypogonadism, eunuchoidism, the climacteric, and other conditions due to loss, atrophy or hypofunction of the testes. In the female: palliation of androgen-responsive, advancing, inoperable breast cancer in women who are more than 1 year, but less than 5 years, postmenopausal or who have been proven to have a hormone dependent tumor, as shown by previous…

METHOTREXATE SODIUM INJECTION USP Faulding Antimetabolite Action And Clinical Pharmacology: Methotrexate is an antimetabolite which competitively inhibits the enzyme folic acid reductase. During DNA synthesis and cellular reproduction, folic acid is reduced to tetrahydrofolic acid by the enzyme folic acid reductase. By interfering with the reduction of folic acid, methotrexate interferes with tissue cell reproduction. Generally, the most sensitive cells to the antimetabolite effect of methotrexate are those cells which…

MERSYNDOL® with CODEINE Hoechst Marion Roussel Acetaminophen – Codeine Phosphate – Doxylamine Succinate Analgesic Action And Clinical Pharmacology: Acetaminophen is the major metabolite of phenacetin and acetanilid. Acetaminophen is an effective and fast-acting analgesic which acts centrally to relieve mild to moderate pain. Animal and clinical studies have shown acetaminophen to have antipyretic and analgesic activity equal to that of ASA. Unlike the salicylates, acetaminophen does not interfere with tubular…

MESASAL™ SmithKline Beecham 5-Aminosalicylic Acid Enteric Coated Lower Gastrointestinal Anti-inflammatory Action And Clinical Pharmacology: 5-Aminosalicylic acid (5-ASA) is considered to be the active component of sulfasalazine. Although its mode of action has not been definitely elucidated, 5-ASA is thought to have a topical anti-inflammatory effect which is produced by inhibition of prostaglandin and/or leukotriene synthesis. The tablets have an acrylic based resin coating which is specifically designed to release 5-ASA…

MERREM® Zeneca Meropenem Antibiotic Action And Clinical Pharmacology: Meropenem is a broad spectrum, b-lactamase-resistant, carbapenem antibiotic for parenteral administration. The bactericidal activity of meropenem results from the inhibition of bacterial cell wall synthesis. Meropenem readily penetrates through the cell wall of most gram-positive and gram-negative bacteria to reach penicillin binding protein (PBP) targets. Its greatest affinity is for PBP 2 of E. coli, PBP 2 and 3 of P. aeruginosa…

MERCODOL® with DECAPRYN® Hoechst Marion Roussel Hydrocodone Bitartrate – Etafedrine HCl Sodium Citrate – Doxylamine Succinate Antihistaminic – Antitussive – Decongestant Indications And Clinical Uses: The treatment of cough associated with inflamed mucosa, which does not respond to products of lesser potency. Contra-Indications: Patients receiving MAO inhibitors, sensitivity to any of the components. Precautions: Before prescribing medication to suppress or modify cough, it is important to ascertain that the underlying cause…

MELLARIL® Novartis Pharmaceuticals Thioridazine HCl Tranquilizer – Antipsychotic Action And Clinical Pharmacology: The basic pharmacological profile of thioridazine is similar to that of other phenothiazines, but there are significant differences in the clinical spectrum when compared with other agents of this class. The distinctive features of thioridazine are its low propensity to cause extrapyramidal side effects and its low antiemetic activity. Thioridazine has a wide therapeutic margin. At low and…