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DIABINESE™ Pfizer Chlorpropamide Oral Hypoglycemic Action And Clinical Pharmacology: Chlorpropamide is an orally active hypoglycemic agent which reduces blood sugar concentration without affecting glucose tolerance. It probably acts by stimulating insulin secretion in the presence of functioning pancreatic islet tissue. Chlorpropamide is absorbed readily from the gastrointestinal tract and is bound to plasma proteins. Within 1 hour after a single oral dose, it is detectable in the blood, and the…

DESFERAL® Novartis Pharmaceuticals Deferoxamine Mesylate Iron and Aluminum Chelating Agent Action And Clinical Pharmacology: Deferoxamine is a chelating agent which forms complexes predominantly with trivalent iron and aluminum ions; it is thus of value in the treatment of acute/chronic iron intoxication, and also chronic aluminum overload in dialysis patients with end-stage renal failure (ESRF). Deferoxamine complexes with iron to form ferrioxamine, a stable chelate, which cannot take part in further…

DESOCORT® Galderma Desonide Topical Corticosteroid Action And Clinical Pharmacology: Desonide, like all topical corticosteroids, exhibits anti-inflammatory, antipruritic and vasoconstrictive actions. tag_IndicationsIndications Indications And Clinical Uses: For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Contra-Indications: Tuberculous, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella). Hypersensitivity to any of the components. Not for ophthalmic use. Precautions: General: Systemic absorption of topical corticosteroids…

DEPROIC® Technilab Valproic Acid Anticonvulsant Action And Clinical Pharmacology: Valproic acid exhibits anticonvulsant properties. While the exact mechanism of action is unknown, several investigators have proposed that the anticonvulsive effect of valproic acid can be related to increased gamma-amino-butyric acid (GABA) levels in the brain. The effect on the neuronal membrane is unknown. After oral administration, valproic acid is rapidly absorbed, reaching peak serum levels within 1 to 4 hours….

DEQUADIN® Preparations Roberts Dequalinium Chloride Antibacterial – Antifungal Indications And Clinical Uses: For the treatment of mouth and throat infections. Contra-Indications: Dequalinium chloride sensitivity. Precautions: If irritation persists or sensitization occurs, discontinue use and consult a physician. Adverse Reactions: Allergic reactions have been reported rarely. Dosage And Administration: Lozenges: 1 lozenge sucked slowly every 2 or 3 hours. In severe infections, increase frequency of administration. Oral Paint: Apply freely to…

DERMOVATE® Glaxo Wellcome Clobetasol 17-Propionate Topical Corticosteroid Action And Clinical Pharmacology: The corticosteroids are a class of compounds comprising steroid hormones secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects. Topical corticosteroids such as clobetasol are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic…

DEPO-MEDROL® Pharmacia & Upjohn Methylprednisolone Acetate Glucocorticoid Action And Clinical Pharmacology: Depo-Medrol is a sterile aqueous suspension of the synthetic glucocorticoid methylprednisolone acetate. It has a strong and prolonged anti-inflammatory, immunosuppressive and antiallergic activity. Depo-Medrol can be administered i.m. for a prolonged systemic activity as well as in situ for a local treatment. The prolonged activity of Depo-Medrol is explained by the slow release of the active substance. Indications And…

DEPO-MEDROL® with Lidocaine Pharmacia & Upjohn Methylprednisolone Acetate – Lidocaine HCl Glucocorticoid with Local Anesthetic Action And Clinical Pharmacology: Methylprednisolone is an anti-inflammatory steroid. Estimates of the relative potencies of methylprednisolone and prednisolone range from 1.13 to 2.1 with an average of 1.5. In general the required daily dose of methylprednisolone can be estimated to be two-thirds (or 0.7) the required daily dose of prednisolone. While the effect of parenterally…

DEPO-PROVERA® Pharmacia & Upjohn Medroxyprogesterone Acetate Progestogen Action And Clinical Pharmacology: Medroxyprogesterone acetate is a long-acting progestational steroid (progestogen) derived from a natural source (soybeans). Its long duration of action is a result of slow absorption from the injection site. Depo-Provera does not contain estrogen. For conception control, medroxyprogesterone inhibits the secretion of gonadotropins which, in turn, prevents follicular maturation and ovulation, and results in endometrial thinning. Additional progestational effects…

DEPO-TESTOSTERONE CYPIONATE Pharmacia & Upjohn Testosterone Cypionate Androgen Action And Clinical Pharmacology: Qualitatively similar to testosterone and its esters in physiologic activity, testosterone cypionate has the advantage of prolonged effect. In hypogonadal males, the effect of a single injection of 200 to 400 mg of testosterone cypionate, was observed to be maintained for 2 to 4 weeks, which is 2 to 4 times longer than the effect produced by a…