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NORGESIC™ NORGESIC™ FORTE 3M Pharmaceuticals Orphenadrine Citrate – ASA – Caffeine Analgesic – Skeletal Muscle Relaxant Indications And Clinical Uses: Symptomatic relief of mild to moderate pain. Contraindications, Precautions and Adverse Effects: See Norflex and ASA. Do not exceed the recommended dose without consulting a physician. Reye’s Syndrome may develop in individuals who have chickenpox, influenza, or flu symptoms. Some studies suggest a possible association between the development of Reye’s…

NORINYL® 1/50 Searle Norethindrone – Mestranol Oral Contraceptive Action And Clinical Pharmacology: Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness. Indications And Clinical Uses: Prevention of pregnancy. Contra-Indications: History of or actual thrombophlebitis or thromboembolic…

NORITATE® Dermik Laboratories Canada Metronidazole Antirosacea Agent Action And Clinical Pharmacology: Metronidazole topical cream is particularly effective against the inflammatory papulopustular component of rosacea. The mechanisms by which metronidazole act in reducing inflammatory lesions of rosacea are unknown, but may include an antibacterial and/or an anti-inflammatory effect. Indications And Clinical Uses: For topical application in the treatment of inflammatory papules, pustules and erythema of rosacea. Contra-Indications: In individuals with a…

NORLUTATE® Parke-Davis Norethindrone Acetate Progestational Agent Action And Clinical Pharmacology: Norethindrone acetate differs from norethindrone only in potency; the acetate is approximately twice as potent. Transforms proliferative endometrium into secretory endometrium. Inhibits (at the usual dose range) the secretion of pituitary gonadotropins, which in turn prevents follicular maturation and ovulation. May also demonstrate some estrogenic, anabolic or androgenic activity but should not be relied upon. Indications And Clinical Uses: Amenorrhea;…

NORFLEX™ 3M Pharmaceuticals Orphenadrine Citrate Skeletal Muscle Relaxant Action And Clinical Pharmacology: The mode of therapeutic action has not been clearly identified but may be related to its analgesic properties. Orphenadrine citrate also possesses anticholinergic actions. Norflex is an extended release formulation that gives a peak level of 60 ng/mL at 8 hours following a 100 mg dose, as opposed to an immediate release product that gives a peak of…

NORCURON® Organon Vecuronium Bromide Nondepolarizing Neuromuscular Blocking Agent Action And Clinical Pharmacology: Vecuronium is a nondepolarizing neuromuscular blocking agent possessing all of the characteristic curariform pharmacological actions of this class of drugs. It acts by competing for cholinergic receptors at the motor end-plate. The antagonism to acetylcholine is inhibited and neuromuscular block is reversed by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine. Vecuronium is about a third more potent…

NIX® Dermal Cream Glaxo Wellcome Permethrin Topical Scabicide Action And Clinical Pharmacology: Permethrin is a synthetic pyrethroid, which is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance. Lag…

NIX® Creme Rinse Warner-Lambert Consumer Healthcare Permethrin Topical Pediculicide – Ovicide Action And Clinical Pharmacology: Permethrin is a synthetic pyrethroid, active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance….

NOLVADEX® NOLVADEX®-D Zeneca Tamoxifen Citrate Antineoplastic Action And Clinical Pharmacology: Tamoxifen, the active ingredient, is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects are related to its ability to compete with estrogen for binding sites in target tissues such as breast and uterus. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA), and causes the regression of already established…

NITROLINGUAL® PUMPSPRAY Rhône-Poulenc Rorer Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal action of nitroglycerin is that of all nitrates, namely, relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demand rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds. Dilation…