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NUTROPIN® NUTROPIN® AQ Roche Somatropin Growth Hormone Action And Clinical Pharmacology: General: Somatropin is a human growth hormone (hGH) produced by recombinant DNA technology. The amino acid sequence of the somatropin protein is identical to that of pituitary-derived human growth hormone. In vitro and in vivo preclinical testing, and clinical testing have demonstrated that somatropin is therapeutically equivalent to pituitary-derived human growth hormone in pharmacokinetics, in stimulation of linear growth…

NOZINAN® Rhône-Poulenc Rorer Methotrimeprazine Neuroleptic Action And Clinical Pharmacology: Methotrimeprazine possesses antipsychotic, tranquilizing, anxiolytic, sedative and analgesic properties and it is also a potent potentiator of anesthetics. Methotrimeprazine possesses strong sedative properties. It potentiates ether and hexobarbital anesthesia as well as morphine analgesia. It also exerts a potent anti-apomorphine effect, a hypothermic action 3 times more potent than that of chlorpromazine and strong antispasmodic and anti-histaminic effects. Methotrimeprazine is capable…

NUMORPHAN® DuPont Pharma Oxymorphone HCl Analgesic Action And Clinical Pharmacology: Oxymorphone is a potent narcotic analgesic. When administered parenterally, 1 mg is approximately equivalent in analgesic activity to 10 mg of morphine sulfate. The onset of action of parenterally injected oxymorphone is rapid and the initial effects are usually perceived within 5 to 10 minutes, with analgesia persisting for approximately 3 to 6 hours. Oxymorphone is conjugated with glucuronic acid…

NUROMAX™ Glaxo Wellcome Doxacurium Chloride Nondepolarizing Skeletal Neuromuscular Blocking Agent Action And Clinical Pharmacology: Doxacurium is a long-acting, nondepolarizing, skeletal neuromuscular blocking agent for i.v. administration. Nondepolarizing agents antagonize the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plates. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine. Pharmacodynamics: Doxacurium is approximately 2.5 to 3 times more potent than…

NOVO-VALPROIC Novopharm Valproic Acid Anticonvulsant Action And Clinical Pharmacology: Although not yet established, the mechanism of valproic acid’s anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA). The effect of the drug on the neuronal membrane is unknown. Valproic acid is rapidly absorbed after oral administration, with peak serum levels occurring approximately 1 to 4 hours after a single oral dose. The half-life of valproic acid…

NOVO-VERAMIL SR Novopharm Verapamil HCl Antiarrhythmic – Antianginal – Antihypertensive Antihypertensive Action And Clinical Pharmacology: Angina and Arrhythmia: Verapamil, a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist) is believed to exert its antiarrhythmic and antianginal effects by selectively inhibiting transmembrane influx of calcium ions in cardiac muscle, coronary and systemic arteries and in cells of the intracardiac conduction system. Verapamil blocks the transmembrane influx of calcium…

NOVOLIN®GE Preparations Novo Nordisk Insulin Human (Biosynthetic) Antidiabetic Agent Action And Clinical Pharmacology: Novolin®ge Biosynthetic Human Insulin is a polypeptide structurally identical to natural human insulin. Novolin®ge is produced by recombinant DNA technology, using Saccharomyces cerevisiae (baker’s yeast). The content of immunoreactive peptides derived from the used microorganism (yeast) is undetectable (less than 1 ppm by weight of the dry insulin) as determined by enzyme linked immunoabsorbent assay. When administered…

NOVOCAIN® Sanofi Procaine HCl Local Anesthetic Action And Clinical Pharmacology: Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibres….

NOVAMOXIN® Novopharm Amoxicillin Trihydrate Antibiotic Action And Clinical Pharmacology: Amoxicillin exerts its bactericidal action by interfering with bacterial cell wall synthesis. Indications And Clinical Uses: The treatment of infections due to susceptible strains of the following microorganisms: Gram-negative organisms: H. influenzae, P. mirabilis and N. gonorrhea. Gram-positive organisms: streptococci (including S. faecalis and S. pneumoniae). Amoxicillin is not active against P. aeruginosa, indole-positive Proteus species, S. marcescens, Klebsiella and Enterobacter…

NOVASOURCE™ RENAL Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A nutritionally complete, calorically dense, moderate protein formula with a vitamin/mineral profile designed for dialysis patients with acute and chronic renal failure. Appropriate for both oral and tube feeding use. Precautions: Not for parenteral administration. Dosage And Administration: 1 000 mL or 8 360 kJ (4.2 Tetra Brik Paks or 2 000 kcal) provides at least 100% of the Canadian…