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PEPCID AC® Johnson & Johnsonheart• Merck Famotidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Famotidine is a competitive inhibitor of histamine H2-receptors. The primary clinically important pharmacologic activity of famotidine is inhibition of gastric juice secretion. Famotidine reduces the acid and pepsin content, as well as the volume, of basal, nocturnal, and stimulated gastric secretion. Pharmacokinetics: Famotidine is incompletely absorbed. The bioavailability of oral doses is 40 to 45%….

PEPCID® PEPCID® I.V. MSD Famotidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Famotidine is a competitive inhibitor of histamine H2-receptors. The primary clinically important pharmacologic activity is inhibition of gastric juice secretion. Famotidine reduces the acid and pepsin content, as well as the volume, of basal, nocturnal, and stimulated gastric secretion. In both normal volunteers and hypersecretors, famotidine inhibited basal nocturnal and daytime gastric secretion, as well as secretion…

PENTASA® Hoechst Marion Roussel 5-Aminosalicylic Acid Gastrointestinal Anti-inflammatory Action And Clinical Pharmacology: Pentasa is a unique, ethylcellulose-coated, delayed-release formulation of 5-ASA, an aminosalicylate, gastrointestinal anti-inflammatory agent for oral administration. Aminosalicylates are considered to be first line therapy for inflammatory bowel diseases. 5-ASA is known to be therapeutically active in Crohn’s disease and ulcerative colitis. Although the mechanism of action of 5-ASA is unknown, its therapeutic effect appears to be nonsystemic….

PENTACARINAT® Rhône-Poulenc Rorer Pentamidine Isethionate Antiparasitic Agent Action And Clinical Pharmacology: Pentamidine isethionate is a member of a class of compounds known as an aromatic diamidines. The precise mechanism of antiprotozoal action of pentamidine isethionate has not been fully elucidated. Several mechanisms of action have been suggested including inhibition of DNA, RNA, phospholipid and protein synthesis, but the relative role of each mechanism to the overall antiprotozoal activity may vary…

PENGLOBE® Astra Bacampicillin HCl Antibiotic Action And Clinical Pharmacology: Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides. Indications And Clinical Uses: For infections at the following sites: upper and lower respiratory…

PENICILLIN G PENICILLIN V General Monograph, Benzylpenicillin Phenoxymethylpenicillin Antibiotic Action And Clinical Pharmacology: Penicillins G and V, known as the natural penicillins, are bactericidal against susceptible organisms. Penicillins interfere with the synthesis of cell wall mucopeptides, resulting in the formation of defective cell walls that will lyse and eventually result in death of the organism. The spectra of activity of penicillins G and V are similar. Penicillin G is more…

PEDIATRIC ELECTROLYTE Pharmascience Electrolytes Electrolyte Maintenance Indications And Clinical Uses: Oral administration of required electrolytes and water to patients with mild or moderate diarrhea; for maintenance of body water and electrolyte balance and prevention of dehydration secondary to acute diarrhea in infants and children. Precautions: Severe dehydration secondary to diarrhea and other conditions incurring large fluid and electrolyte losses requires parenteral therapy initially. With intractable vomiting, adynamic ileus, intestinal obstruction…

PedvaxHIB® MSD Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) Vaccine Action And Clinical Pharmacology: Disease Epidemiology: Prior to the introduction of Haemophilus b conjugate vaccines, H. influenzae type b (Haemophilus b) was the most frequent cause of bacterial meningitis and a leading cause of serious systemic bacterial disease in young children worldwide. Haemophilus b disease occurred primarily in children under 5 years of age in the United States prior to…

PEGLYTE™ Pharmascience PEG-Electrolytes Gastrointestinal Lavage Action And Clinical Pharmacology: Peglyte cleanses the bowel by induction of diarrhea. The osmotic activity of polyethylene glycol 3350, in combination with the electrolyte concentration, results in virtually no net absorption or secretion of ions or water. Accordingly, large volumes may be administered without significant changes in fluid and electrolyte balance. Indications And Clinical Uses: For bowel cleansing prior to colonoscopy or barium enema x-ray…

PAXIL® SmithKline Beecham Paroxetine HCl Antidepressant – Antiobsessional – Antipanic Agent Action And Clinical Pharmacology: Paroxetine is a potent and selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor (SSRI). This activity of the drug on brain neurons is thought to be responsible for its antidepressant action as well as its efficacy in the treatment of obsessive-compulsive disorder (OCD) and panic disorder. Paroxetine is a phenylpiperidine derivative which is chemically unrelated to the…