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PHOSPHATE-NOVARTIS Novartis Pharmaceuticals Sodium Acid Phosphate Hypercalciuria – Electrolyte Replenisher Indications And Clinical Uses: Hypercalciuria, electrolyte replenisher. Contra-Indications: Do not use this medication if hyperphosphatemia is present or in the presence of severe impairment of renal function (less than 30% of normal). Manufacturers’ Warnings In Clinical States: Use carefully in patients with cardiac disease treated with digitalis and in conditions where high potassium concentration may be encountered such as: adrenal…

PHOSPHATES SOLUTION Pharmascience Sodium Phosphates Laxative Action And Clinical Pharmacology: Depending on dosage, sodium phosphates oral solution is useful as a laxative in the relief of constipation, or as a bowel evacuant for a variety of diagnostic, surgical and therapeutic indications. Dibasic sodium phosphate and monobasic sodium phosphate are poorly absorbed from the gastrointestinal tract and retain water in the lumen of the intestine. When administered orally, they produce a…

PHOTOFRIN® Ligand Porfimer Sodium Antineoplastic Photosensitizing Agent Action And Clinical Pharmacology: Pharmacodynamics: The cytotoxic and antitumor actions of porfimer sodium are light and oxygen dependent. Photodynamic therapy (PDT) with porfimer sodium is a 2 stage process. The first stage is the i.v. injection of porfimer sodium. Clearance from a variety of tissues occurs over 40 to 72 hours; but tumor, skin, and organs of the reticuloendothelial system (including liver and…

PHENERGAN® Preparations Novartis Consumer Health Promethazine HCl Antihistamine Action And Clinical Pharmacology: Promethazine is an antihistamine with sedative, antiemetic and antispasmodic properties. In addition, it exerts local anesthetic effects and potentiates analgesics, anesthetics and other CNS depressants. Indications And Clinical Uses: Allergic reactions: hay fever, urticaria, vasomotor rhinitis, skin allergies, poison ivy, insect bites; for the relief of pruritus due to various dermatologic conditions. Nausea and vomiting of various etiologies:…

PHENERGAN® Injectable Rhône-Poulenc Rorer Promethazine HCl Antihistamine Action And Clinical Pharmacology: Promethazine is an antihistamine with sedative, antiemetic and antispasmodic properties. In addition, it exerts local anesthetic effects and potentiates analgesics, anesthetics and other CNS depressants. Indications And Clinical Uses: Allergic reactions: hay fever, urticaria, vasomotor rhinitis, skin allergies, poison ivy, insect bites; for the relief of pruritus due to various dermatologic conditions. Nausea and vomiting of various etiologies: motion…

PHENYTOIN General Monograph, Diphenylhydantoin Anticonvulsant Action And Clinical Pharmacology: Phenytoin is an anticonvulsant which elevates the seizure threshold in the motor cortex by limiting the post-tetanic potentiation (PTP) of synaptic transmission. It exerts this effect by preventing the excessive accumulation of intracellular sodium during tetanic stimulation by either reducing the passive influx of sodium or increasing the efficiency of the sodium pump. By limiting PTP, phenytoin prevents the spread of…

PHENERGAN® EXPECTORANT with Codeine Novartis Consumer Health Promethazine HCl – Potassium Guaiacolsulfonate – Codeine Phosphate Cough Therapy Indications And Clinical Uses: For symptomatic relief of coughs due to colds and minor upper respiratory tract infections. To facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum which does not respond to products of lesser potency. Contra-Indications: Sensitivity to any of the components, patients receiving MAO inhibitors. Not recommended…

PERSANTINE® Boehringer Ingelheim Dipyridamole Coronary Vasodilator – Inhibitor of Platelet Adhesion and Aggregation Action And Clinical Pharmacology: Dipyridamole normalizes increased platelet adhesiveness and tendency to aggregate (Hellem’s method). Dipyridamole has been found to lengthen abnormally shortened platelet survival time in a dose-dependent manner; 400 mg/day or 100 mg/day plus 1 g ASA. It is believed that platelet reactivity and interaction with prosthetic cardiac valve surfaces, resulting in abnormal shortened platelet…

PETHIDINE INJECTION BP Faulding Meperidine HCl Opioid Analgesic Action And Clinical Pharmacology: Meperidine is a narcotic analgesic with multiple actions qualitatively similar to those of morphine. The most prominent of these actions involve the CNS and organs which are composed of smooth muscle. Analgesia and sedation are the principal actions of therapeutic value. Some evidence suggests that meperidine may produce less smooth muscle spasm, constipation, and depression of the cough…

PHARMORUBICIN® Pharmacia & Upjohn Epirubicin HCl Antineoplastic Action And Clinical Pharmacology: The mechanism of action of epirubicin, although not completely elucidated, is mainly related to its ability to bind to nucleic acids by intercalation of the planar anthracycline nucleus with the DNA double helix. Binding to cell membranes as well as to plasma proteins may also be involved. Cell culture studies have demonstrated rapid cell penetration and perinucleolar chromatin binding,…