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Retrovir (AZT) Glaxo Wellcome Zidovudine Antiretroviral Agent Action And Clinical Pharmacology: Zidovudine is a potent inhibitor of the in vitro replication of some retroviruses including human immunodeficiency virus, HIV. Zidovudine is a thymidine analogue in which the 3-hydroxy (-OH) group is replaced by an azido(-N3) group. Cellular thymidine kinase converts zidovudine into zidovudine monophosphate. The monophosphate is further converted into the diphosphate by cellular thymidylate kinase and to the triphosphate…

RESOURCE® PLUS Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high-calorie liquid preparation providing complete, balanced nutrition. Energy density is 1 490 kJ (355 kcal)/Tetra Pak and provides a concentrated source of calories in a limited volume for patients with high protein requirements. When utilized to provide total nutrition, Resource Plus can deliver high energy intakes required by hypermetabolic patients who are nutritionally depleted, and are unable to tolerate…

RESOURCE® Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A complete balanced low-residue liquid nutrition supplement for use in feeding situations where the patient’s diet requires support or where conditions preclude normal food intake. Precautions: Not for parenteral use. Shake Tetra Pak of liquid well before opening. Dosage And Administration: Oral: As a supplement with or between meals: 1 to 3 Tetra Paks daily, 1 050 to 3 150 kJ…

RESONIUM CALCIUM Sanofi Calcium Polystyrene Sulfonate Ion Exchange Resin Action And Clinical Pharmacology: Calcium polystyrene sulfonate is a cation exchange resin prepared in the calcium phase. Each gram of resin has a theoretical in vitro exchange capacity of about 1.3 to 2 mmol of potassium. In vivo, the actual amount of potassium bound will be less than this. The sodium content of the resin is less than 1 mg/g. The…

REQUIP™ SmithKline Beecham Ropinirole HCl Antiparkinsonian Agent – Dopamine Agonist Action And Clinical Pharmacology: Ropinirole is a non-ergoline dopamine agonist, which activates postsynaptic dopamine receptors. In vitro studies have shown that ropinirole binds with high affinity to cloned human D2, D3, and D4 receptors. The antiparkinson activity of ropinirole is believed to be due to its stimulatory effects on central postsynaptic dopamine D2 receptors within the caudate-putamen. Ropinirole is a…

RESOURCE® DIABETIC Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high nitrogen, fibre containing complete liquid formula. Designed for persons with Type 1 or Type 2 diabetes or stress hyperglycemia and normal gastrointestinal function. For oral or tube feeding use. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 1 250 mL or 5 550 kJ (5 cans or 1…

RESOURCE® FRUIT BEVERAGE Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: For patients requiring oral supplementation. For the dietary management of increased protein and calorie needs in the following patient groups: oncology, anorexia, pre-and post-operative, bowel preparation and fat malabsorption. Follow physician’s instructions for use. Precautions: Not for parenteral administration. Dosage: 8 Tetra Paks [1 880 mL or 6 020 kJ (1 440 kcal)] provides 1 440 kcal and at…

RENOVA® Janssen-Ortho Tretinoin Agent for the Treatment of Photodamaged Skin Action And Clinical Pharmacology: Tretinoin significantly reduces clinical signs of photodamaged skin such as fine wrinkles, mottled hyperpigmentation and roughness. While the exact mechanism of action of tretinoin is unknown, the clinical improvements are accompanied by the following histologic changes: increased epidermal and granular layer thickness, reduced melanin content and stratum corneum alterations. Indications And Clinical Uses: For the treatment…

RENEDIL® Hoechst Marion Roussel Felodipine Antihypertensive Agent Action And Clinical Pharmacology: Felodipine is a calcium ion influx inhibitor (calcium channel blocker). Felodipine is a member of the dihydropyridine class of calcium channel blockers. Mechanism of Action: The therapeutic effect of this group of drugs is believed to be related to their specific cellular action of selectively inhibiting transmembrane influx of calcium ions into cardiac muscle and vascular smooth muscle. The…

REOPRO™ Lilly Abciximab Chimeric Monoclonal Antiplatelet Antibody Action And Clinical Pharmacology: General: Abciximab is the Fab fragment of the chimeric monoclonal antibody 7E3. It selectively binds to the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor located on the surface of human platelets. Abciximab inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor and other adhesive molecules to GPIIb/IIIa receptor sites on activated platelets. Pharmacokinetics: Following i.v. administration of abciximab, free…