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R & C™ II Spray R & C Pyrethrins – Piperonyl Butoxide Spray Insecticide Indications And Clinical Uses: For use on lice and lice eggs on garments, bedding, mattresses and furniture. Manufacturers’ Warnings In Clinical States: Not for use on humans or animals. Precautions: Contents under pressure. Do not puncture or incinerate can. Do not use near heat or store at temperatures above 50°C. Avoid spraying in eyes. May be…

RIOPAN® RIOPAN® PLUS Whitehall-Robins Magaldrate Magaldrate – Simethicone Antacid Antacid – Antiflatulent Indications And Clinical Uses: Symptomatic relief of heartburn, indigestion and upset stomach due to excess acid, and relief of gas with Riopan Plus. Precautions: Individuals with kidney disease should not take this product except with the advice and supervision of a physician. Do not take with tetracycline antibiotics. Antacids can interfere with the absorption of iron preparations. Do…

RISPERDAL® Oral Solution RISPERDAL® Tablets Janssen-Ortho Risperidone Tartrate Risperidone Antipsychotic Agent Action And Clinical Pharmacology: Risperidone, a benzisoxazole derivative, is a novel antipsychotic drug which binds with high affinity to the serotonin type 2 (5-HT2), dopamine D2, and a1-adrenergic receptors. Risperidone binds with a lower affinity to the a2-adrenergic and histamine H1 receptors. Risperidone does not bind to dopamine D1 or muscarinic cholinergic receptors. Receptor occupancy was also demonstrated in…

RITALIN® RITALIN® SR Novartis Pharmaceuticals Methylphenidate HCI CNS Stimulant Action And Clinical Pharmacology: Methylphenidate is a mild CNS stimulant. The mode of action in man is not completely understood, but methylphenidate presumably activates the brain stem arousal system and cortex to produce its stimulant effect. There is neither specific evidence which clearly establishes the mechanism whereby methylphenidate produces its mental and behavioral effects in children, nor conclusive evidence regarding how…

RIVOTRIL® Roche Clonazepam Anticonvulsant Action And Clinical Pharmacology: Clonazepam has pharmacological properties characteristic of the benzodiazepine class of drugs. Clonazepam has sedative, hypnotic and anticonvulsant properties. As an anticonvulsant it is useful in the management of minor motor seizures (myoclonic seizures) and may be of some value in selected patients with absence spells (petit mal) who have failed to respond satisfactorily to the succinimides. Clonazepam is capable of suppressing the…

RIFAMPIN General Monograph, Antibiotic Pharmacology: Rifampin is a semisynthetic derivative of rifamycin B, an antibiotic produced by Streptomyces mediterranei. Rifampin is active against microorganisms of the genus Mycobacterium, including M. tuberculosis, M. kansasii, M. marinum, M. avium-intracellulare (M. avium complex) and M. leprae. Rifampin is also active against some gram-negative bacteria including N. meningitidis and H. influenzae type b, in addition to some gram-positive bacteria including S. aureus and S. epidermidis….

RIFATER™ Hoechst Marion Roussel Rifampin – Isoniazid – Pyrazinamide Antituberculous Antibiotic Action And Clinical Pharmacology: Rifater is an antibacterial fixed combination product containing 120 mg rifampin, 50 mg isoniazid and 300 mg pyrazinamide used for the treatment of tuberculosis. Rifampin, isoniazid and pyrazinamide are bactericidal agents active against both intracellular and extracellular tuberculosis organisms. Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase,…

RIMACTANE® Novartis Pharmaceuticals Rifampin Antituberculous Antibiotic Action And Clinical Pharmacology: Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase. This is the probable mechanism of action by which rifampin exerts its therapeutic effect. Pharmacokinetics: Absorption: Peak blood levels in normal adults vary widely from individual to individual. Peak levels occur between 2 and 4 hours following the oral administration of a 600 mg…

RIMSO®-50 Roberts Dimethyl Sulfoxide Genitourinary Disorders Action And Clinical Pharmacology: Dimethyl sulfoxide has a wide spectrum of primary pharmacologic activity including: membrane penetrant, solute carrier across membranes, anti-inflammatory, analgesia, diuresis, cholinesterase inhibition, muscle relaxation, vasodilation, penetrant of blood-brain barrier. Although the mode of action of dimethyl sulfoxide as a treatment for various inflammatory genitourinary disorders is speculative at this time, hypotheses centre around the following: anti-inflammation, analgesic, improvement of blood…

RHINOCORT® TURBUHALER® Astra Budesonide Glucocorticosteroid Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short half-life. The mechanism of action of…