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ZANTAC® 75 Glaxo Wellcome Ranitidine HCl Histamine H2-receptor Antagonist Action And Clinical Pharmacology: Ranitidine is an antagonist of histamine at gastric H2-receptor sites. Thus, ranitidine inhibits both basal gastric secretion and gastric acid secretion induced by histamine, pentagastrin and other secretagogues. Inhibition of gastric acid secretion has been observed following i.v., intraduodenal and oral administration of ranitidine. This response is dose-related, a maximum response being achieved at an oral dose…

YUTOPAR® Bristol Ritodrine HCl Uterine Relaxing Agent Action And Clinical Pharmacology: Ritodrine is a beta-receptor agonist, which has been shown by in vitro and vivo pharmacologic studies in animals to exert a preferential effect on the adrenergic receptors such as those in the uterine smooth muscle. Stimulation of the receptors inhibits contractility of the uterine smooth muscle. Beta-adrenergic stimulation in other body systems may lead to some cardiovascular or metabolic…

XYLOCAINE® 4% STERILE SOLUTION Astra Lidocaine HCl Local Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Local anesthetics of the amide type are thought to act within sodium channels of the nerve membrane. Onset of Action: The onset of action is rapid. For retrobulbar injection, 4 mL…

XYLOCARD® Astra Lidocaine HCl Antiarrhythmic Action And Clinical Pharmacology: Mechanism of Action: The mode of action of the antiarrhythmic effect of lidocaine appears to be similar to that of procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 drugs, lidocaine in therapeutic doses does not produce a significant…

YELLOW FEVER VACCINE Connaught Live 17D Virus Vaccine Action And Clinical Pharmacology: The administration of this vaccine stimulates the development of active immunity against Yellow Fever which probably lasts for many years. tag_IndicationsIndications Indications And Clinical Uses: For all persons 6 months of age or older who are traveling to countries which require a certificate of vaccination against Yellow Fever. Under the International Health Regulations the validity period of the…

XYLOCAINE® TOPICAL 5% Astra Lidocaine Oral Topical Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Local anesthetics of the amide type are thought to act within the sodium channels of the nerve membrane. Onset of Action: The onset of action is 3 to 5 minutes when applied…

XYLOCAINE® TOPICAL 4% Astra Lidocaine HCl Oral Topical Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Local anesthetics of the amide type are thought to act within the sodium channels of the nerve membrane. Onset of Action: Anesthesia usually occurs within 1 to 5 minutes depending on…

XYLOCAINE® VISCOUS 2% Astra Lidocaine HCl Topical Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby, effecting local anesthetic action. Local anesthetics of the amide type are thought to act within the sodium channels of the nerve membrane. Onset of Action: After application of Xylocaine Viscous, local anesthesia is achieved within 5…

XYLOCAINE® JELLY 2% Astra Lidocaine HCl Topical Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Local anesthetics of the amide type are thought to act within the sodium channels of the nerve membrane. Onset of Action: Anesthesia is achieved within 5 minutes, depending on the area of…

XYLOCAINE® OINTMENT 5% XYLOCAINE® DENTAL OINTMENT 5% Astra Lidocaine Topical Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Local anesthetics of the amide type are thought to act within the sodium channels of the nerve membrane. Onset of Action: Anesthesia usually occurs within 3 to 5 minutes…