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ZOLADEX® LA Zeneca Goserelin Acetate Luteinizing Hormone-Releasing Hormone Analog (LHRH Analog) Action And Clinical Pharmacology: Goserelin is a synthetic decapeptide analog of gonadotropin releasing hormone (GnRH or LHRH). When given acutely, goserelin stimulates the release of pituitary luteinizing hormone (LH) from the pituitary gland. However, following chronic administration, goserelin is a potent inhibitor of gonadotropin production resulting in gonadal and consequently, accessory sex organ regression. This effect is the basis…

ZOLADEX® Zeneca Goserelin Acetate LHRH Analog Action And Clinical Pharmacology: Goserelin is a synthetic decapeptide analog of gonadotropin releasing hormone (GnRH or LHRH). When given acutely, goserelin releases luteinizing hormone (LH) from the pituitary gland. However, following chronic administration, goserelin is a potent inhibitor of gonadotropin production resulting in gonadal and consequently, accessory sex organ regression. This effect is the basis for the inhibition of growth of chemically-induced rat mammary…

ZOLOFT™ Pfizer Sertraline HCl Antidepressant – Antipanic – Antiobsessional Agent Action And Clinical Pharmacology: The mechanism of action of sertraline is presumed to be linked to its ability to inhibit the neuronal reuptake of serotonin. It has only very weak effects on norepinephrine and dopamine neuronal reuptake. At clinical doses, sertraline blocks the uptake of serotonin into human platelets. Like most clinically effective antidepressants, sertraline downregulates brain norepinephrine and serotonin…

ZONALON Medicis Doxepin HCl Antipruritic Agent Action And Clinical Pharmacology: Doxepin, a dibenzoxepin-derivative tricyclic compound, is a topical antipruritic. While the exact mechanism of antipruritic activity is unknown, doxepin exhibits potent histamine H1 and H2 receptor antagonist activity. Although the sedative effect of systemically absorbed doxepin may contribute to the drug’s antipruritic activity, the antipruritic efficacy of doxepin reportedly does not appear to depend on a sedative effect. tag_IndicationsIndications Indications…

ZITHROMAX™ Pfizer Azithromycin Dihydrate Antibiotic Action And Clinical Pharmacology: Azithromycin, a macrolide antibiotic of the azalide subclass, exerts its antibacterial action by binding to the 50s ribosomal subunits of susceptible bacteria and suppressing protein synthesis. Following oral administration, azithromycin is rapidly absorbed (Tmax = 2 to 3 hours) and distributed widely throughout the body. Rapid movement of azithromycin from blood into tissue results in significantly higher azithromycin concentrations in tissue…

ZOFRAN® Glaxo Wellcome Ondansetron HCl Dihydrate Antiemetic Action And Clinical Pharmacology: Ondansetron is a selective antagonist of the serotonin receptor subtype, 5-HT3. Its precise mode of action in the control of chemotherapy-induced nausea and vomiting is not known. Cytotoxic chemotherapy and radiotherapy are associated with the release of serotonin (5-HT) from enterochromaffin cells of the small intestine, presumably initiating a vomiting reflex through stimulation of 5-HT3 receptors located on vagal…

ZOCOR® Frosst Simvastatin Lipid Metabolism Regulator Action And Clinical Pharmacology: Simvastatin is a cholesterol-lowering agent derived synthetically from a fermentation product of A. terreus. After oral ingestion, simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding b-hydroxyacid form. This principal metabolite is a specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate-limiting step in the…

ZETAR® Preparations Dermik Laboratories Canada Coal Tar Antipsoriatic – Eczema Therapy Indications And Clinical Uses: A therapeutic aid in the treatment of psoriasis and other tar-responsive dermatoses such as atopic dermatitis; lichen simplex chronicus, seborrheic dermatitis, dandruff and nummular eczema. Emulsion: For use in the bath when extensive tar therapy is desired; Shampoo: Psoriasis, seborrhea dandruff, cradle cap, and other oily, itchy scalp conditions. Contra-Indications: Acute inflammation, open or infected…

ZILACTIN® ZILACTIN-B® ZILACTIN Baby® ZILACTIN-L® ZILACTIN-Lip® Zila Pharmaceuticals Benzyl Alcohol Benzocaine Benzocaine Lidocaine Octyl Methoxycinnamate – Homosalate – Oxybenzone – Dimethicone – Menthol Protective – Topical Analgesic – Emollient Preparation Indications And Clinical Uses: Zilactin: Zilactin medicated gel relieves pain and speeds healing of canker sores, fever blisters and cold sores. Zilactin forms a tenacious, occlusive film on the oral mucosa that holds the medication in place. The film can…

ZINCOFAX® Warner-Lambert Consumer Healthcare Zinc Oxide Skin Protective Indications And Clinical Uses: Prevents and treats diaper rash. Precautions: Information for the Patient: For external use only. Avoid contact with eyes; if this occurs, rinse thoroughly with water. If an adverse reaction or irritation occurs, discontinue use and consult your physician. Symptoms And Treatment Of Overdose: Symptoms: If excessive amounts are ingested, vomiting and diarrhea may occur. Treatment: Supportive. Dosage And…