ADRUCIL® Pharmacia & Upjohn Fluorouracil Antineoplastic Action And Clinical Pharmacology: The mechanism of action of fluorouracil is mainly related to competitive inhibition of thymidylate synthetase, the enzyme catalyzing the methylation of deoxyuridylic acid to thymidylic acid. The consequent thymidine deficiency results in inhibition of deoxyribonucleic acid (DNA) synthesis, thus inducing cell death. Also, moderate inhibition of ribonucleic acid (RNA) and incorporation of fluorouracil into RNA have been observed. The predominant…
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Adrucil (Fluorouracil)
(Pharmaceutical)ACT (Vaccination)
(Pharmaceutical)Act-HIB® Connaught Haemophilus b Conjugate Vaccine (Tetanus Protein – Conjugate) Active Immunizing Agent Action And Clinical Pharmacology: Clinical Data (PRP-T): Haemophilus b Conjugate Vaccine has been administered during clinical trials to over 110 000 infants and children in Canada, the U.S., Finland, France, Chile, Israel, and the United Kingdom using local immunization schedules, and has been used widely in immunization programmes. In clinical trials where 921 infants were given the…
Avirax (Acyclovir)
(Pharmaceutical)AVIRAX Fabrigen Acyclovir Antiviral Action And Clinical Pharmacology: Acyclovir, a synthetic acyclic nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster specified thymidine kinase. Acyclovir is a poor substrate for host cell-specified thymidine kinase. Herpes simplex and varicella-zoster specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and acyclovir triphosphate. Acyclovir…
Aspirin (ASA)
(Pharmaceutical)ASPIRIN® Bayer Consumer ASA Analgesic – Anti-inflammatory – Antipyretic – Platelet Aggregation Inhibitor Action And Clinical Pharmacology: ASA interferes with the production of prostaglandins in various organs and tissues through acetylation of the enzyme cyclo-oxygenase. Prostaglandins are themselves powerful irritants and produce headaches and pain on injection in man. Prostaglandins also appear to sensitize pain receptors to other noxious substances such as histamine and bradykinin. By preventing the synthesis and…
St. John’s Wort
(Herbal)General Information Common Name: St. John’s Wort Latin Name: Hypericum perforatium Family: Hypericaceae Other Names: St. John’s Wort; Goatweed; Hypericum; Klamath Weed; Amber touch-and- heal. Indications & Historical Uses St. John’s Wort is one of the most popular herbal remedies for depression. A tea prepared from the leaves and flowering tops of hypericum perforatum L. is widely used in Europe today for its anti depressive effects. It is also used…
Suma
(Herbal)General Information Common Name: Suma Latin Name: Pffafia Paniculata Family: Amaranthaceae Other Names: Brazilian Ginseng. Para Todo. Indications & Historical Uses Suma is one of the most highly regarded herbs from South America. It has been used as an adaptogen, and historically has been used as: Anabolic; Analgesic; Anti-inflammatory; Tonic and nutrient for regeneration; Aid to increase resistance to stress. Contraindications & Precautions Contraindications: None known Precautions: Do not use…
Gotu Kola
(Herbal)General Information Common Name: Gotu Kola Latin Name: Centella Asiatica Family: Umbelliferae [Apiaceae] Other Names: Centella-a specific variety of Gotu Kola. This contains the highest amounts of the active ingredients; Indian penny wort; Hydrocotyle; Marsh penny; Sheep rot; Water penny wort; Talepetrako. Indications & Historical Uses Increases sex drive; Decreases fatigue and depression; Central nervous system stimulant; enhances memory and learning; Treatment of skin conditions such as psoriasis, eczema, lupus…
Guarana
(Herbal)General Information Common Name: Guarana Latin Name: Paullinia Crysan Paullinia sorbilis Family: Sapindaceae Other Names: Brazilian cocoa; Brazilian cola; Uabeno; Guarana gum. Indications & Historical Uses Central Nervous System stimulant; Used for treatment of fatigue, nerve tonic; For Diarrhea, gastrointestinal complaints; For symptoms of PMS: listlessness, lack of concentration and headaches; Appetite suppressant; Historically used as an aphrodisiac; A popular beverage in South America. Contraindications & Precautions Guarana contains two…
Garlic
(Herbal)General Information Common Name: Garlic Latin Name: Allium Sativum Family: Liliaceae Other Names: Allium; Camphor of the poor; Nectar of the gods; Camphor of the poor. Indications & Historical Uses Protect the circulation, lower cholesterol; Protect against and fight infections, colds, and flu; Enhances immune function; Aids in the treatment of arthritis, arteriosclerosis, digestive problems, insomnia, and liver disease; Contraindications & Precautions Nil known. Please See Caution. Precautions: See Caution. …
Dong Quai
(Herbal)General Information Common Name: Dong Quai Latin Name: Angelica Sinesis Indications & Historical Uses Has historically been used for menstrual symptoms, fatigue, debility, and as a liver tonic, anti-inflammatory and anti-spasmodic. Contraindications & Precautions Contraindications: This herbal has major contra-indications, and is not recommended. See Warning, and Pharmacology. Precautions: See below. Adverse Side Effects: Major adverse effects. See Pharmacology Drug Interactions: See below. Dosage Information Dosage: Not recommended. How Supplied:…