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ANUSOL® ANUSOL® PLUS Warner-Lambert Consumer Healthcare Zinc Sulfate Monohydrate Pramoxine HCl – Zinc Sulfate Monohydrate Anorectal Therapy Indications And Clinical Uses: Symptomatic relief of pain and discomfort as in: external and internal hemorrhoids, proctitis, papillitis, cryptitis, fissures, incomplete fistulas and relief of local pain following anorectal surgery. Contra-Indications: History of sensitivity to any component. Precautions: In case of rectal bleeding, consult physician promptly. Adverse Reactions: An occasional patient may experience…

ANUSOL® ANUSOL® PLUS Warner-Lambert Consumer Healthcare Zinc Sulfate Monohydrate Pramoxine HCl – Zinc Sulfate Monohydrate Anorectal Therapy Indications And Clinical Uses: Symptomatic relief of pain and discomfort as in: external and internal hemorrhoids, proctitis, papillitis, cryptitis, fissures, incomplete fistulas and relief of local pain following anorectal surgery. Contra-Indications: History of sensitivity to any component. Precautions: In case of rectal bleeding, consult physician promptly. Adverse Reactions: An occasional patient may experience…

  APO®-ACYCLOVIR Apotex Acyclovir Antiviral Agent Action And Clinical Pharmacology: Acyclovir, a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster specified thymidine kinase. Acyclovir is a poor substrate for host cell-specified thymidine kinase. Herpes simplex and varicella-zoster specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and…

AMOXICILLIN Amoxycillin Antibiotic Pharmacology: Amoxicillin, a semisynthetic penicillin of the aminopenicillin group, is bactericidal against sensitive organisms. It acts through the inhibition of mucopeptide synthesis in the bacterial cell wall. The spectrum of activity of amoxicillin includes H. influenzae, E. coli, P. mirabilis, Salmonella and some Shigella species while also retaining activity against penicillin-sensitive gram-positive bacteria (see Penicillin G/Penicillin V, General Monograph). However, many Enterobacteriaceae, H. Influenzae, Salmonella and Shigella…

AMPICIN® Bristol Ampicillin Sodium Antibiotic Action And Clinical Pharmacology: Ampicillin is a broad-spectrum penicillin, indicated for the treatment of a wide range of bacterial infections caused by ampicillin-sensitive organisms. Ampicillin is similar to benzyl penicillin in its bactericidal action against susceptible organisms during the stage of active multiplication. It acts through the inhibition of cell wall mucopeptide biosynthesis. Ampicillin has a broad spectrum of bactericidal activity against many gram-positive and…

AMIKIN® Bristol Amikacin Sulfate Antibiotic Action And Clinical Pharmacology: Amikacin is a semi-synthetic bactericidal aminoglycoside antibiotic affecting bacterial growth by specific inhibition of protein synthesis in susceptible bacteria and is active primarily against gram negative organisms, including Pseudomonas. A 30 g amikacin sensitivity disc should give a zone inhibition of 17 mm or greater to be sensitive, using the Kirby-Bauer method of disc sensitivity for the causative organism. The pharmacokinetics…

AMICAR® Wyeth-Ayerst Epsilon Aminocaproic Acid Antifibrinolytic Agent Action And Clinical Pharmacology: Epsilon aminocaproic acid is a monoaminocarboxylic acid which acts as an effective inhibitor of fibrinolysis. The beneficial fibrinolysis-inhibitory effects of aminocaproic acid appear to be principally via inhibition of plasminogen activator substances and to a lesser degree, through antiplasmin activity. The drug is absorbed rapidly following oral administration. Whether administered by the oral or i.v. route, a major portion…

ALSOY™ Nestl©, Carnation Soy Infant Formula Indications And Clinical Uses: A nutritionally complete iron fortified soya brand formula for routine feeding of infants from birth if breast-feeding is not an option or if a supplement is required. For milk-free feeding if a soy supplement is required. Dosage And Administration: As determined by the individual infant’s needs for the first year of life. Consult the physician for specific feeding recommendations. Preparation:…

ALLOPURINOL General Monograph, CPhA Xanthine Oxidase Inhibiton This monograph has been compiled by CPhA. It may contain information different from that approved by HPB, Health Canada, and the pharmaceutical manufacturers’ approval has not been requested. Pharmacology: Allopurinol and its active metabolite, oxypurinol, inhibit xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and of xanthine to uric acid. Inhibition of this enzyme accounts for the major pharmacological…

ADRIAMYCIN® Pharmacia & Upjohn Doxorubicin HCl Antineoplastic Agent Action And Clinical Pharmacology: Though not completely elucidated, the mechanism of action of doxorubicin is related to its ability to bind to DNA and inhibit nucleic acid synthesis. Cell culture studies have demonstrated rapid cell penetration and perinucleolar chromatin binding, rapid inhibition of mitotic activity and nucleic acid synthesis, mutagenesis and chromosomal aberrations. Animal studies have shown activity in a wide spectrum…