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MINITRAN™ 3M Pharmaceuticals Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle and consequent dilation of both peripheral arteries and veins, with more prominent effects on the latter. Dilation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure (preload). Arteriolar relaxation reduces systemic vascular resistance…

Introduction Minocin is a tetracycline antibiotic used to treat various bacterial infections, such as urinary tract infections, severe acne, tick fever, chlamydia, gonorrhea, etc. Action And Clinical Pharmacology Minocycline is a tetracycline with antibacterial activity against some Gram-negative and Gram-positive organisms. The action is primarily bacteriostatic and it is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Indications And Clinical Uses Infections due to susceptible strains…

MIOCHOL®-E CIBA Vision Acetylcholine Chloride – Electrolytes Miotic Action And Clinical Pharmacology: Acetylcholine is a naturally occurring neurohormone which mediates nerve impulse transmission at all cholinergic sites involving somatic and autonomic nerves. After release from the nerve ending, acetylcholine is rapidly inactivated by the enzyme acetylcholinesterase by hydrolysis to acetic acid and choline. Direct application of acetylcholine to the iris will cause rapid miosis of short duration. Topical ocular instillation…

MICROLAX® Pharmacia & Upjohn Micro-Enema Indications And Clinical Uses: Rectal constipation; or, as directed by a physician, to facilitate rectoscopic or sigmoidoscopic examination. Adverse Reactions: No severe reactions have been reported. Very occasionally slight cramps or tenesmus may occur. Dosage: Adults and children: the contents of 1 tube (5 mL) administered rectally but a second tube may be needed in severe cases; children under 3 years, insert only half the…

MICRO-K EXTENCAPS® MICRO-K-10 EXTENCAPS® Wyeth-Ayerst Microencapsulated Potassium Chloride Potassium Supplement Action And Clinical Pharmacology: Potassium ions participate in a number of physiological processes including the maintenance of intracellular tonicity; the transmission of nerve impulses; the contraction of cardiac, skeletal and smooth muscle; and the maintenance of normal renal function. Depletion may occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate…

MICRONOR® Janssen-Ortho Norethindrone Oral Contraceptive Action And Clinical Pharmacology: The mechanism of contraception action of Micronor tablets is multicausal, primarily at the local pelvic level and secondarily at the systemic level. The hormonal effect is mainly progestational. Pelvic effects include changes in the cervical mucus and endometrium. Systemic effects involve mainly the inhibition of secretion of pituitary gonadotropins which in turn prevents follicular maturation and ovulation. Studies by Moghissi, Beck,…

MEXITIL® Boehringer Ingelheim Mexiletine HCl Antiarrhythmic Action And Clinical Pharmacology: Mexiletine is a class 1B antiarrhythmic agent based on the classification system of Vaughan-Williams with local anesthetic properties, similar in structure and activity to lidocaine. Mexiletine blocks the fast sodium channel in cardiac tissues, especially the Purkinje network, without involvement of the autonomic system. Mexiletine reduces the rate of rise and amplitude of the action potential and decreases automaticity (increases…

MICANOL® Canderm Pharma Anthralin Psoriasis Treatment Action And Clinical Pharmacology: Micanol cream provides the action of anthralin in a pharmaceutically elegant base formulated to minimize staining and irritation. With successful treatment, scales will be removed and the lesions will flatten. The lesions will take time to blanch after flattening has occurred. Indications And Clinical Uses: For the treatment of psoriasis. Contra-Indications: Do not use on areas of skin where inflammation…

MICOZOLE Taro Miconazole Nitrate Antifungal Indications And Clinical Uses: For the local treatment of vulvovaginal candidiasis (moniliasis) and has been shown to be effective in both pregnant and nonpregnant women and in women taking oral contraceptives. Miconazole, a synthetic imidazole derivative, exhibits a broad spectrum of antimicrobial activity for the use in the systemic treatment and local treatment of vaginal and topical fungal infections. It is particularly active against Candida…

MICATIN® McNeil Consumer Products Miconazole Nitrate Topical Antifungal Action And Clinical Pharmacology: Miconazole exhibits broad spectrum in vitro fungistatic activity; e.g., against species of the genus Candida. Studies with C. albicans indicate that at low concentrations, miconazole acts primarily on the yeast cell membrane resulting in selective inhibition of the uptake of precursors of RNA and DNA (purines) and mucopolysaccharide (glutamine). In addition, in vitro antibacterial activity has been reported…