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MENINGOCOCCAL POLYSACCHARIDE VACCINE, GROUPS A, C, Y AND W-135 COMBINED, MENOMUNE® Connaught Vaccine Action And Clinical Pharmacology: Meningitis can be caused by a variety of microorganisms including several sero-groups of meningococci. This vaccine will not stimulate protection against infections caused by organisms other than Groups A, C, Y and W-135 meningococci. It has been demonstrated that the presence of human serum bactericidal antibodies to meningococcal antigens is strongly correlated with…

MEFOXIN® MSD Cefoxitin Sodium Antibiotic Action And Clinical Pharmacology: In vitro studies demonstrate that the bactericidal action of cefoxitin, a cephamycin derived from cephamycin C, results from the inhibition of bacterial cell wall synthesis. Evidence suggests that the methoxy group in the 7a position is responsible for the resistance of cefoxitin to degradation by bacterial beta-lactamases. Cefoxitin is poorly absorbed orally in humans. Cefoxitin, administered parenterally, produces high serum and…

MEGRAL® Glaxo Wellcome Ergotamine Tartrate – Cyclizine HCl – Caffeine Hydrate Migraine Therapy Indications And Clinical Uses: The treatment of vascular headache, migraine and related conditions where distention of cranial vessels appears to be the cause. Contra-Indications: Sepsis, occlusive vascular disease (thromboangiitis obliterans, luetic arteritis, severe arteriosclerosis, coronary artery disease, thrombophlebitis, Raynaud’s disease), thyrotoxicosis, anemia, renal or hepatic disease, hypertension, angina pectoris, peptic ulcer, infectious states, malnutrition, severe pruritus, pregnancy,…

MEGACE® MEGACE® OS Bristol Megestrol Acetate Antineoplastic – Progestogen – Antianorexic – Anticachectic Antianorexic – Anticachectic Action And Clinical Pharmacology: The precise mechanism of action by which megestrol produces its antineoplastic effects is unknown at present. Pharmacologic doses of megestrol exerted a direct cytotoxic effect on human breast cancer cells in vitro and proved capable of modifying and abolishing the stimulatory effects of estrogen on breast cancer cell lines. Megestrol…

Measles Virus Vaccine, Live Attenuated (Dried) Connaught Vaccine Action And Clinical Pharmacology: Measles Virus Vaccine, Live, Attenuated (Dried) is prepared in avian leucosis-free chick embryo fibroblast cultures from the Edmondston Strain of attenuated measles virus, obtained from Dr. J.F. Enders and given an additional 69 passages in chick embryo cell cultures. The diluent for reconstitution for the 1 dose vial is Water for Injection (WFI). The diluent for reconstitution for…

MEDROL® Acne Lotion Pharmacia & Upjohn Methylprednisolone – Aluminum Chlorhydroxide – Sulfur Acne Therapy Action And Clinical Pharmacology: Medrol Acne Lotion has an anti-inflammatory action by virtue of its content of methylprednisolone, as astringent and antiperspirant action by virtue of its content of aluminum chlorhydroxide and a keratolytic effect by virtue of its sulfur content. Sulfur has also demonstrated some antibacterial activity at the concentration used. Indications And Clinical Uses:…

MAXERAN® Hoechst Marion Roussel Metoclopramide HCl Modifier of Upper Gastrointestinal Tract Motility – Antiemetic Action And Clinical Pharmacology: Metoclopramide is a benzamide derivative, structurally related to procainamide and sulpiride. As with sulpiride, it has dopamine-antagonist activity with selective affinity for D-2 (non-adenylate cyclase-linked) receptors. The behavioral, motor, and neuroendocrine effects of metoclopramide have been linked to its antidopaminergic activity. Metoclopramide has antiemetic properties, which are believed to result from its…

MAXIPIME™ Bristol-Myers Squibb Cefepime HCl Antibiotic Action And Clinical Pharmacology: Cefepime is a semi-synthetic broad spectrum cephalosporin antibiotic intended for i.m. or i.v. administration. Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. It has a broad spectrum of activity against a wide range of gram-positive and gram-negative bacteria. The average elimination half-life of cefepime is approximately 2 hours, and does not vary with respect…

MARCAINE® Sanofi Bupivacaine HCl Local Anesthetic Action And Clinical Pharmacology: Bupivacaine stabilizes the neuronal membrane and prevents both the generation and the conduction of nerve impulses, thereby exerting local anesthetic action. The onset of action is rapid, and anesthesia is long lasting. The advantage of bupivacaine over other local anesthetics is in the prolonged duration of effective anesthesia. It is to be noted however, that the duration of action of…

MANERIX® Roche Moclobemide Antidepressant Action And Clinical Pharmacology: Moclobemide is a short-acting, reversible inhibitor of monoamine oxidase (MAO). It is a benzamide derivative which inhibits the deamination of serotonin, norepinephrine and dopamine. This action leads to increased concentrations of these neurotransmitters, which may account for the antidepressant activity of moclobemide. MAOs are currently subclassified into 2 types, A and B, which differ in their substrate specificity. Moclobemide preferentially inhibits MAO-A;…