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MONITAN® Wyeth-Ayerst Acebutolol HCl Antihypertensive – Antianginal Agent Action And Clinical Pharmacology: Acebutolol is a beta-adrenergic receptor blocking agent. In vitro and in vivo animal studies have shown that it has a preferential effect on beta1-adrenoreceptors, chiefly located in cardiac muscle. This preferential effect is not absolute, however, and at higher doses acebutolol also inhibits beta2-adrenoreceptors, chiefly located in the bronchial and vascular musculature. It possesses some partial agonist activity…

MODURET® MSD Hydrochlorothiazide – Amiloride HCl Diuretic – Antihypertensive Action And Clinical Pharmacology: Moduret is a diuretic/antihypertensive combining the potent natriuretic action of hydrochlorothiazide with the potassium conserving property of amiloride. The mild diuretic and antihypertensive actions of amiloride are additive to the natriuretic, diuretic and antihypertensive activity of the thiazide while minimizing the loss of potassium and lessening the likelihood of acid base imbalance. The onset of the diuretic…

MOISTUREL® Westwood-Squibb Petrolatum – Dimethicone Emollient – Moisturizer Indications And Clinical Uses: Heals and protects dry sensitive skin. Relieves associated itching. Contra-Indications: The presence of acute inflammation or a known sensitivity to any of its components. Dosage: Apply to skin as often as needed, preferably after bathing, to soften and smooth dry skin and relieve itching. Availability And Storage: Cream: Each jar contains: petrolatum 30% and dimethicone 1% in a…

MODECATE® MODECATE® CONCENTRATE Squibb Fluphenazine Decanoate Antipsychotic Action And Clinical Pharmacology: The effects of fluphenazine decanoate are the same as those of fluphenazine HCl; however, the slow release of the decanoate derivative of fluphenazine from the site of injection results in a prolonged duration of action. Once released in the blood, fluphenazine decanoate is rapidly hydrolyzed by blood esterases with no attenuation of its antipsychotic action. The onset of action…

MOBIFLEX® Roche Tenoxicam Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Tenoxicam is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. Its mechanism of action, as with other nonsteroidal anti-inflammatory agents, is not yet completely known. Tenoxicam is an inhibitor of prostaglandin biosynthesis both in vitro and in vivo (protects mice against arachidonic acid induced toxicity). In vitro tests of leukocyte peroxidase also suggest that tenoxicam may act as a…

MODITEN® HCl Squibb Fluphenazine HCl Antipsychotic Action And Clinical Pharmacology: Fluphenazine hydrochloride exerts activity at various levels of the CNS as well as on peripheral organ systems, which accounts for its antipsychotic action and side effects. Indirect evidence indicates that the antipsychotic effects of phenothiazines are linked to their effect in blocking dopamine and other catecholamine receptor sites. Fluphenazine has less potentiating effect on CNS depressants and anesthetics and appears…

MIREZE® Allergan Nedocromil Sodium Antiallergic – Anti-inflammatory Action And Clinical Pharmacology: Nedocromil displays specific antiallergic and anti-inflammatory properties. The pharmacological actions of nedocromil in many respects resemble those of sodium cromoglycate, a compound which has been shown to have effects on both the symptoms of ocular allergic inflammation and the level of inflammatory mediators present in the tears. Nedocromil is not only an inhibitor of the immunological release of inflammatory…

MITOMYCIN FOR INJECTION USP Novopharm Antineoplastic Action And Clinical Pharmacology: Mitomycin was first investigated as an antibiotic in Japan. It was then found to be active as an antineoplastic agent. It selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The exact point of mitomycin attachment to DNA remains unknown. There is a correlation between the guanine and cytosine content of DNA and the degree of mitomycin-induced cross-linking. At high concentrations…

MIVACRON® Glaxo Wellcome Mivacurium Chloride Nondepolarizing Skeletal Neuromuscular Blocking Agent Action And Clinical Pharmacology: Mivacurium is a short-acting, nondepolarizing skeletal neuromuscular blocking agent which is hydrolyzed by plasma cholinesterase. Mivacurium results in a blockade of neuromuscular transmission by binding competitively with cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine. Pharmacodynamics: The time to maximum neuromuscular block is similar for mivacurium and intermediate-acting agents (e.g., atracurium), but…

MINIPRESS™ Pfizer Prazosin HCl Antihypertensive Action And Clinical Pharmacology: Prazosin causes a decrease in total peripheral resistance. Animal studies suggest that the vasodilator effect of prazosin is related to selective blockade of post-synaptic alpha1-adrenoceptors. The results of dog forelimb experiments demonstrate that the peripheral vasodilator effect is confined mainly to the level of the resistance vessels (arterioles). Hemodynamic studies have been carried out in man following acute single dose administration…