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PROCTOSEDYL® Hoechst Marion Roussel Hydrocortisone – Framycetin Sulfate – Cinchocaine HCl – Esculin Anorectal Therapy Indications And Clinical Uses: The reduction of swelling, pain and inflammation of hemorrhoids and other rectal lesions. The management of acute and chronic nonspecific proctitis, acute internal hemorrhoids, cryptitis, fissures and incomplete fistulas, internal and external pruritus ani. May be used in pre- and postoperative hemorrhoidectomy and repair of fissures. Contra-Indications: Hydrocortisone must not be…

PROCYTOX® Carter Horner Cyclophosphamide Antineoplastic Action And Clinical Pharmacology: Although it is classified generally as an alkylating agent, cyclophosphamide itself is not an alkylating agent. It appears to be inactive in vitro when tested on cultures of human leukocytes or carcinomatous cells of human origin. It appears active metabolites of the drug exhibit the alkylating action. carc Cyclophosphamide’s metabolism is initiated by the mixed function oxidase enzymes of the liver…

OXYCONTIN® Purdue Frederick Oxycodone HCl Opioid Analgesic Action And Clinical Pharmacology: Oxycodone is a semisynthetic opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, oxycodone produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of…

OXYTOCIN INJECTION, USP Abbott Oxytocic Action And Clinical Pharmacology: Oxytocin synthetic, acts on the smooth muscle of the uterus to stimulate contractions; response depends on the uterine threshold of excitability. It exerts a selective action on the smooth musculature of the uterus, particularly toward the end of pregnancy, during labor and immediately following delivery. Oxytocin stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions and raises the…

PROCAN™ SR Parke-Davis Procainamide HCl Antiarrhythmic Agent Action And Clinical Pharmacology: Procainamide depresses the excitability of cardiac muscle to electrical stimulation, and slows conduction in the atrium, the bundle of His, and the ventricle. The refractory period of the atrium is considerably more prolonged than that of the ventricle. With therapeutic plasma levels of the drug, contractility of the heart is usually not affected nor is cardiac output decreased to…

OXIZOLE® Stiefel Oxiconazole Nitrate Topical Antifungal Action And Clinical Pharmacology: Oxiconazole nitrate is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini,…

OVOL® Preparations Carter Horner Simethicone Antiflatulent Indications And Clinical Uses: Specifically for symptomatic treatment of gastrointestinal discomfort due to entrapped gas. Relief of infant colic. Symptoms And Treatment Of Overdose: Symptoms and Treatment: Treatment symptomatic. Dosage And Administration: Drops: Infants, 0.25 to 0.50 mL with or after each meal. May be added to formula or given directly from dropper. Maximum: 6 mL/24 hours. Tablets: Adults: 40 mg (2 tablets, 4…

OSTAC® Roche Clodronate Disodium Bone Metabolism Regulator Action And Clinical Pharmacology: Clodronate belongs to the class of bisphosphonates which act primarily on bone. This tissue specificity is due to the high affinity of bisphosphonates for calcium phosphate crystals. Clodronate forms complexes with the hydroxyapatite of bone, altering the crystalline structure in such a way that dissolution of the crystals is inhibited. The major effect of clodronate is to inhibit osteoclast-mediated…

Bionutrix Osteonutrix: Osteonutrix is a specialized Bionutrix herbal preparation designed by physicians at Bionutrix to maximize bone health. In this premium product, Bionutrix has combined four important supplements in this special formulation as they work synergistically together to arrest cartilage deterioration and to rebuild damaged cartilage. Supportive in: Osteoarthritis – decreases pain and increases mobility in people suffering from osteoarthritis Restoring damaged bone joint tissue in osteoarthritis Tendonitis and bursitis…

ORTHOCLONE OKT® 3 Janssen-Ortho Muromonab-CD3 Immunosuppressant Action And Clinical Pharmacology: Muromonab-CD3 sterile solution is a murine monoclonal antibody to the T3 (CD3) antigen of human T cells which functions as an immunosuppressant. It is for i.v. use only. The antibody is a biochemically purified IgG2a immunoglobulin with a heavy chain of approximately 50 000 daltons and a light chain of approximately 25 000 daltons. It is directed to a glycoprotein…