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PANCREASE® PANCREASE® MT Janssen-Ortho Pancrelipase Digestant Action And Clinical Pharmacology: The enteric-coated microtablets resist gastric inactivation and deliver predictable, high levels of biologically active pancreatic enzymes (lipase, amylase, and protease) into the duodenum. The enzymes catalyze the hydrolysis of fats into glycerol and fatty acids, proteins into proteoses and derived substances, and starch into dextrins and sugars. Pharmacokinetics: Absorption: The intestinal bioavailability of Pancrease MT 16 capsules was determined, in…

PANOCAINE® Hoechst Marion Roussel Benzocaine – Tetracaine HCl Oral Topical Anesthetic Action And Clinical Pharmacology: Panocaine is a local anesthetic of the ester type which rapidly produces surface anesthesia following application to the mucosa of the oral cavity in clinical dentistry. Panocaine has a short duration of action and is ineffective when applied to intact skin. Indications And Clinical Uses: For use in the oral cavity for minimizing the pain…

PANECTYL® Rhône-Poulenc Rorer Trimeprazine Tartrate Antipruritic – Antihistamine Action And Clinical Pharmacology: Trimeprazine is a propylamino phenothiazine derivative with reduced central activity and enhanced antihistaminic and antipruritic effects. It is a potent histamine antagonist. Trimeprazine possesses sedative properties, and is active in suppressing apomorphine induced vomiting in the dog. No evidence of teratogenic effect has been demonstrated in animal studies. Indications And Clinical Uses: Pruritus regardless of site or etiology….

PACIS™ Faulding Bacillus Calmette-Guerin (BCG), substrain Montreal Antineoplastic Action And Clinical Pharmacology: PACIS (Bacillus Calmette-Guerin (BCG), substrain Montreal) promotes a local inflammatory reaction with histiocytic and leukocytic infiltration in the urinary bladder. The local inflammatory effects are associated with an apparent elimination or reduction of superficial cancerous lesions of the urinary bladder. The exact mechanism by which this is accomplished is unknown. Indications And Clinical Uses: For intravesical use in…

PALAFER® CF SmithKline Beecham Ferrous Fumarate Compound Prenatal Supplement Indications And Clinical Uses: For the treatment of hypochromic anemia and avitaminosis C and to prevent megaloblastic anemia of pregnancy due to folic acid depletion. Contra-Indications: Hemosiderosis, hemochromatosis. Iron compounds are also contraindicated in the treatment of hemolytic anemias unless an iron-deficient state also exists, since storage of iron with a possible exogenous hemosiderosis can result. Precautions: Where anemia exists, its…

PACLITAXEL INJECTION Boehringer Ingelheim Antineoplastic Caution: Paclitaxel is a toxic product and should be administered only by or under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel injection should be pre-treated using corticosteroids, antihistamines, and H2 antagonists (for example dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). All clinical studies referred to in this product monograph were conducted…

PURINETHOL® Glaxo Wellcome Mercaptopurine Antileukemic Action And Clinical Pharmacology: Clinical studies have shown the absorption of an oral dose of mercaptopurine in man is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown. I.V. administration of an investigational preparation of mercaptopurine revealed a plasma half-disappearance time of 21 minutes in children and 47 minutes in adults. The volume of distribution usually exceeded that…

PULMICORT® NEBUAMP® Astra Budesonide Glucocorticosteroid – Asthma Therapy Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short half-life. The late…

PULMICORT® TURBUHALER® Astra Budesonide Glucocorticosteroid for the Treatment of Bronchial Asthma Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short…

PROZAC® Lilly Fluoxetine HCl Antidepressant – Antiobsessional – Antibulimic Action And Clinical Pharmacology: The antidepressant, antiobsessional, and antibulimic actions of fluoxetine are presumed to be linked to its ability to selectively inhibit the neuronal reuptake of serotonin. At clinically relevant doses fluoxetine blocks the uptake of serotonin into human platelets. Antagonism of muscarinic, histaminergic and a1-adrenergic receptors has been hypothesized to be associated with various anticholinergic, sedative and cardiovascular effects…