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PENTACARINAT® Rhône-Poulenc Rorer Pentamidine Isethionate Antiparasitic Agent Action And Clinical Pharmacology: Pentamidine isethionate is a member of a class of compounds known as an aromatic diamidines. The precise mechanism of antiprotozoal action of pentamidine isethionate has not been fully elucidated. Several mechanisms of action have been suggested including inhibition of DNA, RNA, phospholipid and protein synthesis, but the relative role of each mechanism to the overall antiprotozoal activity may vary…

PENGLOBE® Astra Bacampicillin HCl Antibiotic Action And Clinical Pharmacology: Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides. Indications And Clinical Uses: For infections at the following sites: upper and lower respiratory…

PENICILLIN G PENICILLIN V General Monograph, Benzylpenicillin Phenoxymethylpenicillin Antibiotic Action And Clinical Pharmacology: Penicillins G and V, known as the natural penicillins, are bactericidal against susceptible organisms. Penicillins interfere with the synthesis of cell wall mucopeptides, resulting in the formation of defective cell walls that will lyse and eventually result in death of the organism. The spectra of activity of penicillins G and V are similar. Penicillin G is more…

PEDIATRIC ELECTROLYTE Pharmascience Electrolytes Electrolyte Maintenance Indications And Clinical Uses: Oral administration of required electrolytes and water to patients with mild or moderate diarrhea; for maintenance of body water and electrolyte balance and prevention of dehydration secondary to acute diarrhea in infants and children. Precautions: Severe dehydration secondary to diarrhea and other conditions incurring large fluid and electrolyte losses requires parenteral therapy initially. With intractable vomiting, adynamic ileus, intestinal obstruction…

PedvaxHIB® MSD Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) Vaccine Action And Clinical Pharmacology: Disease Epidemiology: Prior to the introduction of Haemophilus b conjugate vaccines, H. influenzae type b (Haemophilus b) was the most frequent cause of bacterial meningitis and a leading cause of serious systemic bacterial disease in young children worldwide. Haemophilus b disease occurred primarily in children under 5 years of age in the United States prior to…

PEGLYTE™ Pharmascience PEG-Electrolytes Gastrointestinal Lavage Action And Clinical Pharmacology: Peglyte cleanses the bowel by induction of diarrhea. The osmotic activity of polyethylene glycol 3350, in combination with the electrolyte concentration, results in virtually no net absorption or secretion of ions or water. Accordingly, large volumes may be administered without significant changes in fluid and electrolyte balance. Indications And Clinical Uses: For bowel cleansing prior to colonoscopy or barium enema x-ray…

PAXIL® SmithKline Beecham Paroxetine HCl Antidepressant – Antiobsessional – Antipanic Agent Action And Clinical Pharmacology: Paroxetine is a potent and selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor (SSRI). This activity of the drug on brain neurons is thought to be responsible for its antidepressant action as well as its efficacy in the treatment of obsessive-compulsive disorder (OCD) and panic disorder. Paroxetine is a phenylpiperidine derivative which is chemically unrelated to the…

PEDIALYTE® PEDIALYTE® FREEZER POPS Abbott Oral Electrolyte Maintenance Solution Electrolyte Maintenance Indications And Clinical Uses: Prevents dehydration and restores fluids and minerals lost in patients with mild or moderate diarrhea and other conditions causing mild to moderate dehydration; for maintenance of body water and electrolytes and prevention of dehydration secondary to acute diarrhea in infants and children; for oral supplementation and for maintenance following corrective parenteral therapy of severe dehydration;…

PARSITAN® Rh´ne-Poulenc Rorer Ethopropazine HCl Antiparkinsonian Agent Indications And Clinical Uses: Symptomatic treatment of drug induced extrapyramidal manifestations and of Parkinson’s disease of postencephalitic, arteriosclerotic or idiopathic etiology. Contra-Indications: Glaucoma and hypersensitivity to phenothiazine drugs. Precautions: Use with caution in patients with cardiac disease, prostatic hypertrophy or pyloric obstruction. Adverse Reactions: Drowsiness, dizziness, lassitude, blurred vision, dryness of mouth, paresthesia, headache. Very rarely, epigastric distress, confusion and ataxia. Neuroleptic Malignant…

PARVOLEX® Bioniche Acetylcysteine Mucolytic – Antidote for Acetaminophen Poisoning Action And Clinical Pharmacology: The viscosity of respiratory mucous secretions depends primarily on the content of mucoprotein and to a smaller extent on the concentration of desoxyribonucleic acid (DNA). The proportion of DNA is increased with the presence of purulent material, due to cellular debris. The mucolytic action of acetylcysteine is related to the sulphydryl group in the molecule. This group…