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PERI-COLACE® Roberts Docusate Sodium – Casanthranol Laxative – Stool Softener Indications And Clinical Uses: Occasional or temporary constipation. Contra-Indications: When symptoms of appendicitis or intestinal obstruction are present. Precautions: Do not use in presence of abdominal pain, nausea, fever or vomiting. Use with caution in lactating women as the compound may cause increased stooling in the infant. Frequent or prolonged use may result in dependence on laxatives. Do not administer…

PERIACTIN® Johnson & Johnson Merck Cyproheptadine HCl Antihistaminic Action And Clinical Pharmacology: Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects recommended for the symptomatic treatment of allergic disorders and pruritic dermatoses, as well as certain types of vascular headaches. Indications And Clinical Uses: Cyproheptadine has a wide range of antiallergic and antipruritic activity and can be used successfully in the treatment of acute and chronic allergies…

PERIDEX® Zila Pharmaceuticals Chlorhexidine Gluconate Antigingivitis Action And Clinical Pharmacology: Chlorhexidine provides antimicrobial activity during oral rinsing which is maintained between rinsings. Microbiologic sampling of plaque has shown a general reduction of both aerobic and anaerobic bacterial counts ranging from 54 to 97% through 6 months’ clinical use. Rinsing with chlorhexidine inhibits the buildup and maturation of plaque by reducing certain microbes regarded as gingival pathogens, thereby reducing gingivitis. Chlorhexidine…

PEPTOL® Carter Horner Cimetidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Cimetidine inhibits competitively the action of histamine at the histamine H2 receptor and it is not an anticholinergic agent. It inhibits both daytime and nocturnal basal gastric acid secretion. Similarly, gastric acid secretion stimulated by food, histamine, pentagastrin, insulin and caffeine is inhibited by cimetidine. After oral administration, cimetidine is absorbed rapidly. The plasma half-life is about 2…

PERCOCET® PERCOCET®-DEMI DuPont Pharma Oxycodone HCl – Acetaminophen Opioid Analgesic Action And Clinical Pharmacology: The principal ingredient, oxycodone, is a semisynthetic opioid analgesic with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the CNS and organs composed of smooth muscle. The principal actions of therapeutic value of the oxycodone in Percocet are analgesia and sedation. Oxycodone is similar to codeine and methadone in that…

PERCODAN® PERCODAN®-DEMI DuPont Pharma Oxycodone HCl – ASA Opioid Analgesic Action And Clinical Pharmacology: The principal ingredient, oxycodone, is a semisynthetic opioid analgesic with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the CNS and organs composed of smooth muscle. The principal actions of therapeutic value of the oxycodone in Percodan are analgesia and sedation. Oxycodone is similar to codeine and methadone in that…

PENTASPAN® DuPont Pharma Pentastarch Plasma Volume Expander Action And Clinical Pharmacology: The colloidal properties of pentastarch render it useful as a plasma volume expander. I.V. infusion of pentastarch results in expansion of the plasma volume in excess of the volume infused. This expansion persists for approximately 18 to 24 hours and is expected to improve the hemodynamic status for 12 to 18 hours. Pentastarch molecules below 50 000 molecular weight…

PEPCID AC® Johnson & Johnsonheart• Merck Famotidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Famotidine is a competitive inhibitor of histamine H2-receptors. The primary clinically important pharmacologic activity of famotidine is inhibition of gastric juice secretion. Famotidine reduces the acid and pepsin content, as well as the volume, of basal, nocturnal, and stimulated gastric secretion. Pharmacokinetics: Famotidine is incompletely absorbed. The bioavailability of oral doses is 40 to 45%….

PEPCID® PEPCID® I.V. MSD Famotidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Famotidine is a competitive inhibitor of histamine H2-receptors. The primary clinically important pharmacologic activity is inhibition of gastric juice secretion. Famotidine reduces the acid and pepsin content, as well as the volume, of basal, nocturnal, and stimulated gastric secretion. In both normal volunteers and hypersecretors, famotidine inhibited basal nocturnal and daytime gastric secretion, as well as secretion…

PENTASA® Hoechst Marion Roussel 5-Aminosalicylic Acid Gastrointestinal Anti-inflammatory Action And Clinical Pharmacology: Pentasa is a unique, ethylcellulose-coated, delayed-release formulation of 5-ASA, an aminosalicylate, gastrointestinal anti-inflammatory agent for oral administration. Aminosalicylates are considered to be first line therapy for inflammatory bowel diseases. 5-ASA is known to be therapeutically active in Crohn’s disease and ulcerative colitis. Although the mechanism of action of 5-ASA is unknown, its therapeutic effect appears to be nonsystemic….