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PREGNYL® Organon Chorionic Gonadotropin Gonadotropin Action And Clinical Pharmacology: Chorionic gonadotropin is a glycoprotein substance, with a molecular weight of approximately 38 600, secreted by the placenta and obtained from the urine of pregnant women. It is composed of nonidentical and noncovalently linked a and b subunits. The a subunit of CG is essentially identical to the a subunits of the human pituitary gonadotropins, luteinizing hormone and follicle-stimulating hormone, as…

PREMARIN® VAGINAL CREAM Wyeth-Ayerst Conjugated Estrogens Vaginitis Therapy Action And Clinical Pharmacology: Conjugated estrogens are a mixture of estrogens obtained exclusively from natural sources occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It contains estrone, equilin, and 17a-dihydroequilin, together with smaller amounts of 17a-estradiol, equilenin, and 17a-dihydroequilenin as salts of their sulfate esters. Metabolic and Somatic…

POTASSIUM CHLORIDE FOR INJECTION CONCENTRATE USP Astra Electrolyte Replenisher Indications And Clinical Uses: The treatment of potassium depletion in patients with hypokalemia; treatment of digitalis intoxication. The i.v. route is indicated when the patient is unable to take potassium orally or if hypokalemia is severe. Contra-Indications: Renal impairment with oliguria or azotemia, untreated Addison’s disease, hyperadrenalism associated with adrenogenital syndrome, extensive tissue breakdown as in severe burns, acute dehydration, heat…

PRANDASE® Bayer Acarbose Oral Antidiabetic Agent – Alpha-glucosidase Inhibitor Action And Clinical Pharmacology: Acarbose is a complex oligosaccharide that inhibits a-glucosidase activity in the brush border membrane of the small intestine. This delays the digestion of ingested carbohydrates, thereby resulting in a smoothing and lowering of blood glucose concentration following meals (postprandial). As a consequence of decreases in plasma glucose postprandial increases, acarbose reduces levels of glycosylated hemoglobin in patients…

PONSTAN® Parke-Davis Mefenamic Acid Analgesic Action And Clinical Pharmacology: Mefenamic acid, an anthranilic acid derivative, is a nonsteroidal anti-inflammatory drug (NSAID) with demonstrated anti-inflammatory, analgesic and antipyretic activity in laboratory animals. Its mode of action is not completely understood, but may be related to prostaglandin synthetase inhibition. In animal studies the drug was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site. Pharmacokinetics: Mefenamic…

PONTOCAINE® Sanofi Tetracaine HCl Anesthetic Action And Clinical Pharmacology: Tetracaine is 2-(dimethylamino) ethyl p-(butylamino) benzoate monohydrochloride. It is a white crystalline odorless powder that is readily soluble in water, physiologic saline solution or dextrose solution. Tetracaine is a local anesthetic of the ester-linkage type, related to procaine. Tetracaine is detoxified by plasma esterases to para-aminobenzoic acid and diethylaminoethanol. tag_IndicationsIndications Indications And Clinical Uses: Where spinal anesthesia is indicated for operations…

POSTACNE® Dermik Laboratories Canada Sulfur Acne Therapy Indications And Clinical Uses: For use in early mild adolescent acne or excessively oily skin and as maintenance therapy for acne that has been controlled. Precautions: Keep away from eyes. Discontinue use temporarily if excessive irritation or scaling occurs. For external use only. Dosage: Shake lotion well. Apply a thin film over area, allow to dry, blend in with skin by gently brushing…

POLYSPORIN® ANTIBIOTIC BURN CREAM Warner-Lambert Consumer Healthcare Polymyxin B Sulfate – Gramicidin – Lidocaine HCl Antibiotic – Anesthetic – Antipruritic Indications And Clinical Uses: For treatment and prevention of infection of minor burns and scalds and relief of skin pain. Contra-Indications: Hypersensitivity to any of the components. Precautions: As with other antibiotic preparations, prolonged use may result in overgrowth of nonsusceptible organisms. Appropriate measures should be taken if this occurs….

PONDOCILLIN® Leo Pivampicillin Antibiotic Action And Clinical Pharmacology: Pivampicillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in excess of 99% of the pivampicillin absorbed are converted to ampicillin within 15 minutes of absorption….

POLIOVIRUS VACCINE LIVE ORAL TRIVALENT Connaught Poliovirus Types 1, 2 and 3 Active Immunizing Agent Action And Clinical Pharmacology: The purpose of administering any attenuated, live virus vaccine is to stimulate the immune system to produce an active immunity by stimulating natural infection without producing clinical symptoms of the disease. To accomplish this with live poliovirus vaccine, it is necessary for the virus to multiply in the intestinal tract. A…