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RIMACTANE® Novartis Pharmaceuticals Rifampin Antituberculous Antibiotic Action And Clinical Pharmacology: Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase. This is the probable mechanism of action by which rifampin exerts its therapeutic effect. Pharmacokinetics: Absorption: Peak blood levels in normal adults vary widely from individual to individual. Peak levels occur between 2 and 4 hours following the oral administration of a 600 mg…

RHINOCORT® TURBUHALER® Astra Budesonide Glucocorticosteroid Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short half-life. The mechanism of action of…

RHINOCORT® AQUA Astra Budesonide Glucocorticosteroid Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short half-life. The mechanism of action of…

RHEOMACRODEX® Medisan Pharmaceuticals Dextran 40 Plasma Volume Expander Action And Clinical Pharmacology: The biological properties of dextrans are functions of molecular structure, average molecular weight and molecular weight distribution. For Rheomacrodex these have been selected so that the preparation exerts both a general and a microcirculatory flow improving effect, at the same time producing a rapid increase in plasma volume. Following the infusion of Rheomacrodex, approximately 60% of the dextran…

REVIA® DuPont Pharma Naltrexone HCl Opioid Antagonist Action And Clinical Pharmacology: Pharmacodynamic Actions: Naltrexone is a pure opioid antagonist. It markedly attenuates or completely blocks, reversibly, the subjective effects of i.v. administered opioids. [In this context, the term opioid is used to describe 1) classic morphine-like agonists and 2) analgesics possessing agonist and antagonist activity (e.g., butorphanol, nalbuphine and pentazocine).] When coadministered with morphine, on a chronic basis, naltrexone blocks…

RESOURCE® JUST FOR KIDS Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A standard lactose-, gluten- and fiber-free liquid formula designed to meet the nutritional needs of children 1 to 12 years of age with normal gastrointestinal function. Appropriate for both oral or tube feeding use. Precautions: Not for parenteral administration. Not for patients with galactosemia. Dosage And Administration: 1 200 mL or 5 020 kJ (5.1 aseptic Tetra Brik…

RESOURCE® PLUS Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high-calorie liquid preparation providing complete, balanced nutrition. Energy density is 1 490 kJ (355 kcal)/Tetra Pak and provides a concentrated source of calories in a limited volume for patients with high protein requirements. When utilized to provide total nutrition, Resource Plus can deliver high energy intakes required by hypermetabolic patients who are nutritionally depleted, and are unable to tolerate…

RESOURCE® Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A complete balanced low-residue liquid nutrition supplement for use in feeding situations where the patient’s diet requires support or where conditions preclude normal food intake. Precautions: Not for parenteral use. Shake Tetra Pak of liquid well before opening. Dosage And Administration: Oral: As a supplement with or between meals: 1 to 3 Tetra Paks daily, 1 050 to 3 150 kJ…

RESONIUM CALCIUM Sanofi Calcium Polystyrene Sulfonate Ion Exchange Resin Action And Clinical Pharmacology: Calcium polystyrene sulfonate is a cation exchange resin prepared in the calcium phase. Each gram of resin has a theoretical in vitro exchange capacity of about 1.3 to 2 mmol of potassium. In vivo, the actual amount of potassium bound will be less than this. The sodium content of the resin is less than 1 mg/g. The…

REQUIP™ SmithKline Beecham Ropinirole HCl Antiparkinsonian Agent – Dopamine Agonist Action And Clinical Pharmacology: Ropinirole is a non-ergoline dopamine agonist, which activates postsynaptic dopamine receptors. In vitro studies have shown that ropinirole binds with high affinity to cloned human D2, D3, and D4 receptors. The antiparkinson activity of ropinirole is believed to be due to its stimulatory effects on central postsynaptic dopamine D2 receptors within the caudate-putamen. Ropinirole is a…