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SALAGEN DESCRIPTION SALAGEN® Tablets contain pilocarpine hydrochloride, a cholinergic agonist for oral use. Pilocarpine hydrochloride is a hygroscopic, odorless, bitter tasting white crystal or powder which is soluble in water and alcohol and virtually insoluble in most non-polar solvents. Pilocarpine hydrochloride, with a chemical name of (3 S-cis )-2(3 H )-Furanone, 3-ethyldihydro-4-[(1-methyl-1 H -imidazol-5-yl)methyl] monohydrochloride, has a molecular weight of 244.72. Each SALAGEN® Tablet for oral administration contains 5 mg…

SANDIMMUNE (CYCLOSPORINE) DESCRIPTION Cyclosporine, the active principle in Sandimmune® (cyclosporine) is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. It is produced as a metabolite by the fungus species Beauveria nivea. Chemically, cyclosporine is designated as [ R -[ R*,R*-(E )]]-cyclic (L-alanyl – D – alanyl- N -methyl – L – leucyl- N -methyl-L-leucyl- N -methyl – L – valyl-3-hydroxy- N , 4-dimethyl-L-2-amino – 6 – octenoyl-L-(alpha)-amino-butyryl –…

SYNVISC® Biomatrix Hylan G-F 20 Viscosupplementation Description: Synvisc (hylan G-F 20) is a sterile, nonpyrogenic, elastoviscous fluid containing hylans. Hylans are derivatives of hyaluronan (sodium salt of hyaluronic acid) and consist of repeating disaccharide units of N-acetylglucosamine and sodium glucuronate. Synvisc contains hylan fluid and hylan gel slurry (8 mg±2 mg/mL) in buffered physiological sodium chloride solution (pH 7.2±0.3). Synvisc is biologically similar to hyaluronan. Hyaluronan is a component of…

RYTHMOL® Knoll Propafenone HCl Antiarrhythmic Agent Action And Clinical Pharmacology: Propafenone is an antiarrhythmic agent which possesses class 1c properties in the modified electrophysiological classification of Vaughan-Williams. It has a direct stabilizing action on myocardial cell membranes. The electrophysiological effect of propafenone manifests itself as a reduction of the upstroke velocity (Phase 0) of the monophasic action potential, while phase 4 spontaneous automaticity is depressed. Diastolic excitability threshold is increased…

SYNPHASIC® Searle Norethindrone-Ethinyl Estradiol Oral Contraceptive Action and Clinical Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness.IndicationsIndications: Indications And Clinical Uses: Prevention of pregnancy. Contra-Indications: History of or actual thrombophlebitis or thromboembolic disorders; history of…

ROYCHLOR® Waymar Potassium Chloride Potassium Replacement Therapy Indications And Clinical Uses: The treatment of potassium depletion found in patients with hypokalemia and metabolic alkalosis, digitalis intoxication, inadequate dietary potassium intake and those patients receiving digitalis and diuretics, e.g. congestive heart failure, and hepatic cirrhosis with ascites. For treatment of hypertensive patients undergoing longterm diuretic therapy, hyperaldosteronism states with normal renal function, potassium losing nephropathy and certain diarrheal states. Contra-Indications: In…

ROYVAC® Waymar Magnesium Citrate – Bisacodyl Bowel Evacuant Indications And Clinical Uses: Preparation of the colon for radiology (prior to barium enemas or i.v. pyelograms) surgery and many proctological procedures. Precautions: Do not use any of these preparations when undiagnosed abdominal pain, nausea or vomiting are present. Frequent or prolonged use of these preparations may result in dependence on laxatives. Do not administer Royvac to persons who cannot swallow without…

ROGITINE® Novartis Pharmaceuticals Phentolamine Mesylate Alpha-adrenoreceptor Blocker Action And Clinical Pharmacology: Phentolamine produces an alpha-adrenergic block of relatively short duration. It also has direct but less marked positive inotropic and chronotropic effects on cardiac muscle and vasodilator effects on vascular smooth muscle. tag_IndicationsIndications Indications And Clinical Uses: Prevention and control of hypertensive episodes in patients with pheochromocytoma, preoperatively and during surgical excision. Prevention of dermal necrosis and sloughing following i.v….

ROVAMYCINE® Rhône-Poulenc Rorer Spiramycin Antibiotic Action And Clinical Pharmacology: It is active against the following gram-positive organisms: S. aureus (including penicillin resistant strains), beta-hemolytic streptococci, S. viridans, S. faecalis and S. pneumoniae, C. diphtheriae, clostridia. Except for B. pertussis, H. influenzae (approximately 50% of strains) and neisseria, gram-negative organisms are generally considered as resistant to spiramycin. Bacterial resistance to spiramycin has been reported to develop, including cross resistance between spiramycin…

ROBINUL® ROBINUL® FORTE Wyeth-Ayerst Glycopyrrolate Anticholinergic Indications And Clinical Uses: The management of gastrointestinal disorders amenable to anticholinergic therapy, such as: duodenal ulcer, duodenitis, pylorospasm; gastric ulcer, gastritis, hiatal hernia, hyperchlorhydria, pyrosis, aerophagia, gastroenteritis; esophagitis; cholecystitis, chronic pancreatitis; spastic and irritable colon, ulcerative colitis, functional bowel distress, diverticulitis, acute enteritis, diarrhea; and splenic flexure syndrome, neurogenic gastrointestinal disturbances. Contra-Indications: Glaucoma, urinary bladder neck obstruction, pyloric obstruction, stenosis with significant gastric…