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ROCEPHIN® Roche Ceftriaxone Sodium Antibiotic Action And Clinical Pharmacology: In vitro studies indicate that the bactericidal action of ceftriaxone results from the inhibition of cell-wall synthesis. In E. coli, ceftriaxone showed a high affinity for penicillin binding proteins (PBP) 1a and 3 and a moderate affinity for 1b and 2. In H. influenzae, the highest affinity was shown for PBP 4 and PBP 5. The binding affinity to PBP 4…

ROCALTROL® Roche Calcitriol Vitamin D3 Metabolite Action And Clinical Pharmacology: The supply of vitamin D in man depends on dietary intake and/or exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D3 (cholecalciferol). Vitamin D3 (cholecalciferol) must be metabolized in the liver and the kidneys before it is fully active on its target tissues. The initial transformation is catalyzed by a vitamin D3-25-hydroxylase enzyme (25-OH-ase)…

ROBAXIN® ROBAXIN®-750 Whitehall-Robins Methocarbamol Skeletal Muscle Relaxant Action And Clinical Pharmacology: The mechanism of action of methocarbamol has not been established, but may be due to general CNS depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber. Methocarbamol is metabolized to yield a dealkylated and a hydroxylated product. These 2 metabolites are found primarily as glucuronide and sulfate…

Introduction Robaxacet is an adult medication used to treat muscle spasms and pain. It helps to relax the muscles and decrease the pain. Its effects can be felt within 1 hour. Action And Clinical Pharmacology This product provides a dual approach to the management of discomforts associated with musculoskeletal disorders. The mechanism of action of methocarbamol has not been established, but may be due to general CNS depression. It has no…

ROBAXISAL®-C Whitehall-Robins Methocarbamol – ASA – Codeine Phosphate Skeletal Muscle Relaxant – Analgesic Action And Clinical Pharmacology: The mechanism of action of methocarbamol has not been established, but may be due to general CNS depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fibre. Methocarbamol is metabolized to yield a dealkylated and a hydroxylated product. These 2 metabolites are…

ROBAXISAL® ROBAXISAL® EXTRA STRENGTH Whitehall-Robins Methocarbamol – ASA Skeletal Muscle Relaxant – Analgesic Action And Clinical Pharmacology: The mechanism of action of methocarbamol has not been established, but may be due to general CNS depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fibre. Methocarbamol is metabolized to yield a dealkylated and a hydroxylated product. These 2 metabolites are…

ROBINUL® INJECTABLE Wyeth-Ayerst Glycopyrrolate Anticholinergic Action And Clinical Pharmacology: Glycopyrrolate, like other anticholinergic (antimuscarinic) agents, competitively antagonizes the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. Glycopyrrolate antagonizes muscarinic symptoms (e.g., bronchorrhea, bronchospasm, bradycardia and intestinal hypermotility) induced by cholinergic drugs such as the anticholinesterases. As a premedicant, glycopyrrolate injectable reduces excessive pharyngeal, tracheal and bronchial…

R & C™ II Spray R & C Pyrethrins – Piperonyl Butoxide Spray Insecticide Indications And Clinical Uses: For use on lice and lice eggs on garments, bedding, mattresses and furniture. Manufacturers’ Warnings In Clinical States: Not for use on humans or animals. Precautions: Contents under pressure. Do not puncture or incinerate can. Do not use near heat or store at temperatures above 50°C. Avoid spraying in eyes. May be…

RITALIN® RITALIN® SR Novartis Pharmaceuticals Methylphenidate HCI CNS Stimulant Action And Clinical Pharmacology: Methylphenidate is a mild CNS stimulant. The mode of action in man is not completely understood, but methylphenidate presumably activates the brain stem arousal system and cortex to produce its stimulant effect. There is neither specific evidence which clearly establishes the mechanism whereby methylphenidate produces its mental and behavioral effects in children, nor conclusive evidence regarding how…

RIVOTRIL® Roche Clonazepam Anticonvulsant Action And Clinical Pharmacology: Clonazepam has pharmacological properties characteristic of the benzodiazepine class of drugs. Clonazepam has sedative, hypnotic and anticonvulsant properties. As an anticonvulsant it is useful in the management of minor motor seizures (myoclonic seizures) and may be of some value in selected patients with absence spells (petit mal) who have failed to respond satisfactorily to the succinimides. Clonazepam is capable of suppressing the…