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BELLERGAL® SPACETABS® Novartis Pharmaceuticals Belladonna – Ergotamine Tartrate – Phenobarbital Anticholinergic – Antispasmodic – Sedative Indications And Clinical Uses: Functional symptoms such as hot flushes, perspiration, palpitations, dizzy spells, restlessness, apprehension, fatigue, insomnia, headache, for example in patients with anxiety-tension states associated with menopause. Menopausal women who are treated with Bellergal, exhibiting atrophic vaginitis and/or osteoporosis, require specific therapy for these conditions if indicated. Contra-Indications: Narrow-angle glaucoma, sepsis, occlusive vascular…

BARBITURATES Amobarbital Butabarbital Pentobarbital Phenobarbital Secobarbital Anticonvulsant – Sedative-Hypnotic Pharmacology: Barbiturates are nonselective central nervous system (CNS) depressants, capable of producing all degrees of depression from mild sedation and hypnosis to general anaesthesia, deep coma and death. The extent of CNS depression varies with the route of administration, dose and pharmacokinetic characteristics of the particular barbiturate. Patient specific factors such as age, physical or emotional state and the concomitant use…

ASASANTINE® Boehringer Ingelheim Dipyridamole – ASA Inhibitor of Platelet Adhesion and Aggregation Action And Clinical Pharmacology: The combined use of dipyridamole and ASA causes a significant reduction in the incidence of new fatal and nonfatal coronary events in patients with a previously documented myocardial infarction. In a randomized, double blind study, the effects of combined dipyridamole and ASA treatment were compared to ASA alone and to placebo in 2 026…

ARIMIDEX® Zeneca Anastrozole Nonsteroidal Aromatase Inhibitor Action And Clinical Pharmacology: Many breast cancers have estrogen receptors and growth of these tumors can be stimulated by estrogens. In postmenopausal women, the principal source of circulating estrogen (primarily estrone) is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues, such as adipose tissue, with further conversion of estrone to estradiol. Many breast cancers also contain aromatase; the importance of tumor-generated…

AQUATAIN® Whitehall-Robins Emollient Indications And Clinical Uses: Emollient for dry, chapped, rough skin. Dosage: Apply as needed several times daily or as prescribed. Availability And Storage: Cream: Each tube of unscented, hypoallergenic cream contains: benzyl alcohol, polawax, isopropyl palmitate, glycerin, sorbitol, lactic acid and water. Tartrazine-free. Tubes of 75 g. Lotion: Each bottle of unscented, hypoallergenic lotion contains: benzyl alcohol, polawax, isopropyl palmitate, glycerin, sorbitol, lactic acid and water. Tartrazine-free….

AQUASOL® E Novartis Consumer Health Vitamin E Vitamin Action And Clinical Pharmacology: Vitamin E is a fat soluble vitamin which is present in many foods and exists in a variety of forms. It is considered an essential element of human nutrition, with many of its actions related to its antioxidant properties. Indications And Clinical Uses: A nutritional supplement for the treatment of vitamin E deficiency. Vitamin E deficiency states are…

AREDIA® Novartis Pharmaceuticals Pamidronate Disodium Bone Metabolism Regulator Action And Clinical Pharmacology: Pamidronate belongs to a class of bisphosphonates (previously termed diphosphonate), which inhibit bone resorption. The therapeutic activity of pamidronate is attributable to its potent anti-osteoclastic activity on bone. In animal studies, at therapeutic doses, pamidronate inhibits bone resorption apparently without inhibiting bone formation and mineralization. The predominant means by which pamidronate reduces bone turnover both in vitro and…

AQUAPHOR® Smith & Nephew Petrolatum Dermatological Base Indications And Clinical Uses: A neutral, anhydrous base for compounding smooth, stable emulsions; highly miscible with both aqueous solutions and other oil-based substances. For severely dry skin. Also helps promote healing of minor skin irritations. Precautions: For external use only. Avoid contact with eyes. If this occurs, rinse thoroughly with water. If rash or irritation occurs or worsens, discontinue use and consult a…

APRESOLINE® Novartis Pharmaceuticals Hydralazine HCl Antihypertensive Action And Clinical Pharmacology: Although the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system. Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. Hydralazine, by altering cellular calcium metabolism, interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating…

ANZEMET™ Hoechst Marion Roussel Dolasetron Mesylate Antiemetic Action And Clinical Pharmacology: Dolasetron and its active metabolite, hydrodolasetron (MDL 74156), are selective 5-HT3 receptor antagonists shown not to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is…