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BRONKAID® MISTOMETER® Sanofi Epinephrine Bronchodilator Action And Clinical Pharmacology: Epinephrine is a sympathomimetic drug that acts on both alpha and beta receptors. Indications: For temporary relief of acute paroxysms of bronchial asthma. Manufacturers’ Warnings In Clinical States: For oral inhalation only. Do not use this product unless a diagnosis of asthma has been made by a physician, if you have heart disease, high blood pressure, thyroid disease, diabetes, or difficulty…

BURINEX® Leo Bumetanide Diuretic Action And Clinical Pharmacology: Bumetanide is a loop diuretic. The diuretic effect of bumetanide results largely from the inhibition of sodium reabsorption in the ascending limb of the loop of Henle. This is shown by a marked reduction in freewater clearance during hydration and tubular solute-free water reabsorption during hydropenia. Bumetanide may have an additional action in the proximal tubule, since phosphaturia has been observed during…

BUSPAR® Bristol Buspirone HCl Anxiolytic Action And Clinical Pharmacology: Buspirone is a psychotropic drug with selective anxiolytic properties which belongs chemically to the class of compounds known as the azaspirodecanediones, not chemically or pharmacologically related to benzodiazepines. Buspirone shares some of the properties of the benzodiazepines and the neuroleptics, as well as demonstrating other pharmacological action. Buspirone attenuates punishment suppressed behavior in animals and exerts a taming effect, but is…

BUTISOL® SODIUM Carter Horner Butabarbital Sodium Sedative – Hypnotic Indications And Clinical Uses: A daytime sedative when mild sedation is required for relief of symptoms of anxiety or tension resulting from emotional, physical, or situational stress. May be used in such conditions as: neuroses and anxiety-tension states, functional gastrointestinal disorders, peptic ulcer, menopausal syndrome, premenstrual tension, hyperthyroidism, essential hypertension, coronary artery disease, congestive heart failure, preoperative apprehension and insomnia. Contra-Indications:…

BRIETAL SODIUM® Lilly Methohexital Sodium Anesthetic Action And Clinical Pharmacology: Compared with thiamylal and thiopental, methohexital is at least twice as potent on a weight basis, and its duration of action is only about half as long. Although the metabolic fate of methohexital in the body is not clear, the drug does not appear to concentrate in fat depots to the extent that other barbiturate anesthetics do. Thus, cumulative effects…

BRONALIDE® Boehringer Ingelheim Flunisolide Corticosteroid Aerosol Action And Clinical Pharmacology: Flunisolide has demonstrated marked anti-inflammatory and anti-allergic activity in classical test systems. It is a corticosteroid which is several hundred times more potent in animal anti-inflammatory assays than the cortisol standard. When inhaled at therapeutic doses it has potent anti-inflammatory activity locally on the bronchial mucosa. Following i.v. administration in man of 2 mg flunisolide, plasma concentrations of 12 to…

Botulism Antitoxin Trivalent Types A, B and E (Equine) Connaught Antitoxin Indications And Clinical Uses: Experimental evidence concerning the amount of circulating antitoxin needed to counteract botulism toxin poisoning by antitoxin therapy is not fully documented. The outcome of treatment depends, as it does in other comparable conditions, largely on the time interval elapsing after onset of symptoms before the peak of absorbed antitoxin is reached. This principle is illustrated…

BRETYLATE® Glaxo Wellcome Bretylium Tosylate Antiarrhythmic Action And Clinical Pharmacology: Bretylium is an adrenergic-neurone blocking agent. The mechanism by which it exerts its antiarrhythmic action is not fully understood. Although evidence has indicated that the benefit of bretylium in abating tachyarrhythmias may be due to its antiadrenergic properties, this has still not been firmly established. Some reports have even indicated that there is a clear-cut dissociation between the neuron-blocking and…

BOTOX® Allergan Botulinum Toxin Type A Neuromuscular Paralytic Agent Action And Clinical Pharmacology: Botulinum toxin type A blocks neuromuscular conduction by binding to receptor sites on motor nerve terminals, entering the nerve terminals, and inhibiting the release of acetylcholine. When injected i.m. at therapeutic doses, botulinum toxin type A produces a partial chemical denervation of the muscle resulting in localized muscle paralysis. When chemically denervated, the muscle may atrophy, axonal…

BIOLON™ Ophtapharma Sodium Hyaluronate Ophthalmosurgical Aid Action And Clinical Pharmacology: Sodium hyaluronate is a physiological material found in both animal and human tissues. It is a polysaccharide consisting of a repeating disaccharide of N-acetylglucosamine and sodium glucuronate, linked by alternating b-1,3 and b-1,4 glycosidic bonds. Chemically identical in all species, hyaluronate can be found in the vitreous and aqueous humor of the eye, in synovial fluid, in skin and in…