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Diaeta (Glyburide)

(Pharmaceutical)

DIABETA® Hoechst Marion Roussel Glyburide Oral Hypoglycemic Action And Clinical Pharmacology: The principal action of glyburide results in an increased insulin release from the beta cells of the pancreas. Other mechanisms leading to a reduction of blood glucose are also believed to be influenced by glyburide. The insertion of an alkylene chain on the benzene nucleus results in a product of very high potency. Schulz and Schmidt indicated that the…

Desquam (Benzoyl Peroxide)

(Pharmaceutical)

DESQUAM-X® Preparations Westwood-Squibb Benzoyl Peroxide Acne Therapy Indications And Clinical Uses: A topical aid for the treatment of acne vulgaris. Contra-Indications: Known sensitivity to any of the components. Precautions: Avoid contact with eyes and mucous membranes. Observe patients carefully for possible local irritation or sensitivity during long-term topical therapy. Apply with caution on neck, circumoral and/or other sensitive areas. If excessive dryness or irritation occurs, discontinue use. May bleach colored…

Dexedrine (Dextroamphetamine)

(Pharmaceutical)

DEXEDRINE® SmithKline Beecham Dextroamphetamine Sulfate Sympathomimetic Action And Clinical Pharmacology: Dextroamphetamine (dexamphetamine, d-amphetamine) sulfate is a sympathomimetic agent with indirect effects on adrenergic receptors. It has alpha-and beta-adrenergic activity. It has actions qualitatively similar to those of amphetamine sulfate but is approximately twice as potent. It has a marked stimulant effect on the CNS, particularly the cerebral cortex and the respiratory and vasomotor centers. Dextroamphetamine sulfate causes a lessening of…

DexIron (Iron Dextran)

(Pharmaceutical)

DEXIRON™ Genpharm Iron Dextran Hematinic – Iron Supplement Action And Clinical Pharmacology: Iron dextran is absorbed from i.m. injection sites into the capillaries and the lymphatic system. Circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiologic forms…

Diabeta (Glyburide)

(Pharmaceutical)

DIABETA® Hoechst Marion Roussel Glyburide Oral Hypoglycemic Action And Clinical Pharmacology: The principal action of glyburide results in an increased insulin release from the beta cells of the pancreas. Other mechanisms leading to a reduction of blood glucose are also believed to be influenced by glyburide. The insertion of an alkylene chain on the benzene nucleus results in a product of very high potency. Schulz and Schmidt indicated that the…

Desferal (Deferoxamine)

(Pharmaceutical)

DESFERAL® Novartis Pharmaceuticals Deferoxamine Mesylate Iron and Aluminum Chelating Agent Action And Clinical Pharmacology: Deferoxamine is a chelating agent which forms complexes predominantly with trivalent iron and aluminum ions; it is thus of value in the treatment of acute/chronic iron intoxication, and also chronic aluminum overload in dialysis patients with end-stage renal failure (ESRF). Deferoxamine complexes with iron to form ferrioxamine, a stable chelate, which cannot take part in further…

Delsym (Dextromethorphan Polistirex)

(Pharmaceutical)

Description Delsym is a cough suppressant that is used to treat cough caused by the common cold or flu. It has an advanced time-release formula. The medicine was invented in 1980s and was the first cough syrup brand to deliver 12 full hours of cough relief. Action And Clinical Pharmacology Dextromethorphan is a centrally acting antitussive which is comparable to codeine on a mg basis for cough suppression but lacking analgesic…

Deltasone (Prednisone)

(Pharmaceutical)

DELTASONE® Pharmacia & Upjohn Prednisone Corticosteroid Action And Clinical Pharmacology: Prednisone is a corticosteroid, which like other steroids, acts by controlling the rate of synthesis of proteins. The corticosteroids react with receptor proteins in the cytoplasm of sensitive cells to form a steroid-receptor complex. The steroid receptor complex moves into the nucleus where it binds to chromatin. Information carried by the steroid or more likely by the receptor protein directs…

Demerol (Meperidine)

(Pharmaceutical)

DEMEROL® Sanofi Meperidine HCl Analgesic Action And Clinical Pharmacology: Meperidine is an opioid analgesic which acts predominantly as a mu-agonist. In its effects on the CNS, meperidine resembles but is not identical to morphine. Analgesic effects are detectable within about 15 minutes following oral administration, reaching a peak within about 2 hours and subsiding gradually over several hours thereafter. Onset of analgesic effect is faster (within 10 minutes) after s.c….

Demadex (Torsemide)

(Pharmaceutical)

DEMADEX® Roche Torsemide Diuretic – Antihypertensive Action And Clinical Pharmacology: Mechanism of Action: Micropuncture studies in animals have shown that torsemide acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the NaK2Clcarrier system. Clinical pharmacology studies have confirmed this site of action in humans, and effects in other segments of the nephron have not been demonstrated. Diuretic activity thus correlates better…