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DELATESTRYL® Squibb Testosterone Enanthate Androgen Indications And Clinical Uses: Androgen therapy in the male (eunuchism, eunuchoidism, impotence of glandular origin, cryptorchidism, climacteric, senile pruritus), and in the female (menorrhagia, frigidity, palliation of premenopausal mammary carcinoma, inhibition of lactation, postpartum breast engorgement, menopausal syndrome), and in males and females (delayed bone healing, spinal paraplegia, senile osteoporosis, dystrophy, cachexia due to wasting illness). Contra-Indications: Androgens are contraindicated in male patients with prostatic…

DELESTROGEN® Squibb Estradiol Valerate Estrogen Indications And Clinical Uses: In nonpregnant women, Delestrogen is indicated in the treatment of amenorrhea (primary and secondary); disturbances of the menstrual cycle (hypomenorrhea, oligomenorrhea, irregular cycles, metrorrhagia); deficiency syndromes (castration, primary ovarian failure, menopause); local manifestations of estrogen deficiency (senile vaginitis, pruritus vulvae); abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology; and for the production of secretory endometrium and…

DARVON-N® Lilly Propoxyphene Napsylate Analgesic Indications And Clinical Uses: For the relief of mild to moderate pain alone or when it is accompanied by fever. Contra-Indications: Hypersensitivity to any of the components Manufacturers’ Warnings In Clinical States: Do not prescribe propoxyphene for patients who are suicidal or addiction-prone. Prescribe propoxyphene with caution for patients taking tranquilizers or antidepressant drugs and patients who use alcohol in excess. Tell your patients not…

DAYPRO™ Searle Oxaprozin Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Oxaprozin is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. The modes of action of oxaprozin, like that of other nonsteroidal anti-inflammatory agents, are not fully established. It is known, however, that it does inhibit prostaglandin synthesis. Pharmacokinetics: Oxaprozin is almost completely absorbed from the gastrointestinal tract, with peak plasma levels attained 2 to 4 hours after administration. The…

DANTRIUM® INTRAVENOUS Procter & Gamble Pharmaceuticals Dantrolene Sodium Management of Malignant Hyperthermia Action And Clinical Pharmacology: Dantrolene is a muscle relaxant acting specifically on skeletal muscles. In isolated muscle preparations, dantrolene uncouples the excitation and contraction of skeletal muscles, probably by interfering with the release of calcium from the sarcoplasmic reticulum. In the anesthetic induced malignant hyperthermia syndrome, evidence points to a predisposing intrinsic abnormality of muscle tissue. In affected…

DARAPRIM® Glaxo Wellcome Pyrimethamine Antimalarial Action And Clinical Pharmacology: Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine does not destroy gametocytes, but arrests sporogony in the mosquito. Peak plasma levels are found between 2 and 4 hours…

DYRENIUM® SmithKline Beecham Triamterene Diuretic Action And Clinical Pharmacology: Triamterene exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogen ions. This natriuretic activity is limited by the amount of sodium reaching its site of action. Although triamterene blocks the increase in this exchange, which is stimulated by mineralocorticoids (chiefly aldosterone), its action takes place through a direct effect…

DUOVENT® UDV Boehringer Ingelheim Ipratropium Bromide – Fenoterol Hydrobromide Bronchodilator Action And Clinical Pharmacology: Duovent UDV inhalation solution is a combination of the anticholinergic bronchodilator ipratropium bromide and the beta2-adrenergic bronchodilator fenoterol hydrobromide. Ipratropium is a quaternary ammonium derivative of atropine and is an anticholinergic drug which has bronchodilator properties. On inhalation of ipratropium the onset of action is noted within 5 to 15 minutes with a peak response between…

DRIXORAL® N.D. Schering Pseudoephedrine Sulfate Decongestant Indications And Clinical Uses: Symptomatic relief of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis and rhinosinusitis, acute and subacute sinusitis, eustachian tube blockage and secretory otitis media. Contra-Indications: Patients receiving or having received MAO inhibitors in the preceding 2 weeks; known hypersensitivity to pressor amines or antihistamines. Precautions: Although pseudoephedrine causes practically no pressor effect in normotensive individuals, it…

DRIXORAL® DRIXTAB® Schering Dexbrompheniramine Maleate – Pseudoephedrine Sulfate Antihistamine – Decongestant Indications And Clinical Uses: Symptomatic relief of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis and rhinosinusitis, acute and subacute sinusitis, eustachian tube blockage and secretory otitis media. Contra-Indications: Patients receiving or having received MAO inhibitors in the preceding 2 weeks; known hypersensitivity to pressor amines or antihistamines. Children under 12 years of age (sustained…