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DIODOQUIN® Glenwood Iodoquinol Amebicide Action And Clinical Pharmacology: Iodoquinol is amebicidal against E. histolytica, D. fragilis and G. lamblia and is considered effective against the trophozoite and cyst forms. Indications And Clinical Uses: In the treatment of intestinal amebiasis. Contra-Indications: Hypersensitivity to any 8-hydroxy-quinoline or iodine-containing preparations, hepatic damage and pre-existing optic neuropathy. tag_WarningWarnings Manufacturers’ Warnings In Clinical States: Optic neuritis, optic atrophy, and peripheral neuropathy have been reported following…

DIOVAN® Novartis Pharmaceuticals Valsartan Angiotensin II AT1 Receptor Blocker Action And Clinical Pharmacology: Valsartan is an orally active angiotensin II AT1 receptor blocker. Valsartan acts selectively on AT1, the receptor subtype that mediates the known cardiovascular actions of angiotensin II, the primary vaso-active hormone of the renin-angiotensin-system. The AT2 receptor subtype, found in tissues such as brain, endometrium, myometrium and fetal kidney and adrenals, plays no known role in cardiovascular…

DIMETAPP®-DM Whitehall-Robins Brompheniramine Maleate – Dextromethorphan HBr – Phenylephrine HCl – Phenylpropanolamine HCl Antihistamine – Antitussive – Decongestant Indications And Clinical Uses: Symptomatic treatment of allergic manifestations of cough, nasal congestion, runny nose accompanying colds and other upper respiratory infections. Contra-Indications: Hypersensitivity to any of the components. Marked hypertension. Do not administer to patients receiving MAO inhibitors. Pregnancy: Safe use during pregnancy has not been established. Precautions: Use with care…

DIMETAPP® Whitehall-Robins Brompheniramine Maleate – Phenylephrine HCl – Phenylpropanolamine HCl Antihistamine – Decongestant Indications And Clinical Uses: Symptomatic relief of the allergic manifestations of respiratory illnesses such as the common cold, seasonal allergies, etc. Contra-Indications: Hypersensitivity to antihistamines or sympathomimetic amines. Patients receiving MAO inhibitors. Precautions: Administer with caution to patients with cardiac or peripheral vascular diseases, glaucoma, hyperthyroidism, chronic lung disease, diabetes mellitus or hypertension, prostate enlargement and bladder…

DIMETANE® Whitehall-Robins Brompheniramine Maleate Antihistamine Indications And Clinical Uses: Prevention and symptomatic relief of manifestations of allergic states such as hay fever, conjunctivitis, angioneurotic edema, pruritus, rhinitis, atopic eczema, urticaria, dermatitis, drug reaction, rhus dermatitis, insect and spider bites. Contra-Indications: Hypersensitivity to antihistamines and patients receiving MAO inhibitors. Precautions: Occupational Hazards: Patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been…

DIGIBIND® Glaxo Wellcome Digoxin Immune Fab (Ovine) Specific Antibody for Digoxin Action And Clinical Pharmacology: Digoxin immune Fab (ovine) is a sterile lyophilized powder of antigen binding fragments (Fab) derived from specific antidigoxin antibodies raised in sheep. It binds molecules of digoxin, making them unavailable for binding at their site of action on cells in the body. The Fab fragment-digoxin complex accumulates in the blood, from which it is excreted…

DIHYDROERGOTAMINE (DHE) Novartis Pharmaceuticals Dihydroergotamine Mesylate Vascular Headache Therapy Action And Clinical Pharmacology: Dihydroergotamine displays moderate to high affinity for various serotonergic receptor subtypes (5-HT1A, 5-HT1C, 5-HT1D, 5-HT2). The compound exerts agonistic activity at the 5-HT1D subtype and antagonistic activity at the 5-HT2 subtype. Dihydroergotamine also displays blocking actions at alpha adrenergic receptor level, with a direct stimulating effect on the smooth muscle of peripheral blood vessels. Its tonic effect…

DILANTIN® INFATABS DILANTIN®-30 PEDIATRIC DILANTIN®-125 Parke-Davis Phenytoin Anticonvulsant Action And Clinical Pharmacology: Dilantin Infatabs and Dilantin-30 Pediatric/Dilantin-125 suspensions are anticonvulsant drugs which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes…

DIDRONEL® Procter & Gamble Pharmaceuticals Etidronate Disodium Bone Metabolism Regulator – Antipagetic Agent – Antihypercalcemic Agent Action And Clinical Pharmacology: Etidronate acts primarily on bone. It can inhibit the formation, growth and dissolution of hydroxyapatite crystals and their amorphous precursors by chemisorption to calcium phosphate surfaces. Inhibition of crystal resorption occurs at lower doses than are required to inhibit crystal growth. Both effects increase as the dose increases. General: The…

DIFFERIN® Galderma Adapalene Acne Therapy Action And Clinical Pharmacology: Adapalene is a chemically stable, retinoid-like compound. Biochemical and pharmacological profile studies have demonstrated that adapalene is a potent modulator of cellular differentiation, keratinization and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Although the exact mode of action of adapalene is unknown, current evidence suggests that topical adapalene normalizes the differentiation of follicular epithelial…