Diodoquin (Iodoquinol)





Action And Clinical Pharmacology: Iodoquinol is amebicidal against E. histolytica, D. fragilis and G. lamblia and is considered effective against the trophozoite and cyst forms.

Indications And Clinical Uses: In the treatment of intestinal amebiasis.

Contra-Indications: Hypersensitivity to any 8-hydroxy-quinoline or iodine-containing preparations, hepatic damage and pre-existing optic neuropathy. tag_WarningWarnings

Manufacturers’ Warnings In Clinical States: Optic neuritis, optic atrophy, and peripheral neuropathy have been reported following prolonged high dosage therapy with halogenated 8-hydroxyquinolines. Long-term use of this drug should be avoided.

Pregnancy and Lactation: Safety for use in pregnancy or during lactation has not been established.

Precautions: Iodoquinol should be used with caution in patients with thyroid disease.

Protein-bound serum iodine levels may be increased during treatment with iodoquinol and therefore interfere with certain thyroid function tests. These effects may persist for as long as 6 months after discontinuation of therapy. Discontinue the drug if hypersensitivity reactions occur.

Adverse Reactions: Skin: various forms of skin eruptions (acneiform papular and pustular; bullae; vegetating or tuberots iododerma), urticaria and pruritus.

Gastrointestinal: nausea, vomiting, abdominal cramps, diarrhea, and pruritus ani.

Fever, chills, headache, vertigo, and enlargement of thyroid have been reported. Optic neuritis, optic atrophy and peripheral neuropathy have been reported in association with prolonged high-dosage 8-hydroxyquinoline therapy.

Dosage And Administration: 210 mg: Usual adult dose: 3 tablets 3 times daily, after meals for 20 days. Children 6 to 12 years: 2 tablets t.i.d. Children under 6: 1 tablet/6.8 kg of body weight, divided into 3 daily doses for 20 days.

650 mg: Usual adult dose: 1 tablet 3 times a day for 20 days, to be taken after meals. Children: For 20 days, 40 mg/kg of body weight daily divided into 3 doses, not to exceed 1.95 g in 24 hours, for 20 days.

Availability And Storage: Each tablet contains: iodoquinol USP 210 or 650 mg. Nonmedicinal ingredients: colloidal silicon dioxide NF, croscarmellose sodium NF, lactose anhydrous NF, magnesium stearate NF, microcrystalline cellulose NF and povidone USP. Bottles of 60. Store at controlled room temperature 15 to 30°C.

DIODOQUIN® Glenwood Iodoquinol Amebicide

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