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NEURONTIN™ Parke-Davis Gabapentin Antiepileptic Action And Clinical Pharmacology: Gabapentin exhibits antiseizure activity in mice and rats both in the maximal electroshock and in the pentylenetetrazol seizure models. Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid) but does not interact with GABA receptors, it is not metabolized to GABA or to GABA agonists, and it is not an inhibitor of GABA uptake or degradation. Gabapentin at concentrations up to…

NEUPOGEN® Amgen Filgrastim Granulocyte Colony Stimulating Factor – Hematopoietic Agent Action And Clinical Pharmacology: Filgrastim is a human granulocyte colony stimulating factor (G-CSF) produced by recombinant DNA technology. G-CSF regulates the production of neutrophils within the bone marrow; endogenous G-CSF is a glycoprotein produced by monocytes, fibroblasts, and endothelial cells. G-CSF is a colony stimulating factor which has been shown to have minimal direct in vivo or in vitro effects…

NAVANE™ Pfizer Thiothixene Antipsychotic Action And Clinical Pharmacology: Thiothixene is an antipsychotic agent of the thioxanthene series. It possesses certain chemical and pharmacologic similarities to the piperazine phenothiazines and differences from the aliphatic group of phenothiazines. Thiothixene’s mode of action has not been clearly established. Indications And Clinical Uses: An antipsychotic agent useful in the management of schizophrenia and other psychotic disorders. As with other antipsychotic agents, some patients resistant…

NAVELBINE® Glaxo Wellcome Vinorelbine Tartrate Antineoplastic Action And Clinical Pharmacology: Vinorelbine is a novel vinca alkaloid which interferes with microtubule assembly. Vinca alkaloids are structurally similar compounds comprising two multiringed units, vindoline and catharanthine. Vinorelbine is a vinca alkaloid in which the catharanthine unit is the site of structural modification. This structural change imparts unique pharmacologic properties which may translate into clinical benefits for patients with various malignancies. The antitumor…

NARDIL® Parke-Davis Phenelzine Sulfate Antidepressant Action And Clinical Pharmacology: Phenelzine is a potent monoamine oxidase (MAO) inhibitor. Monoamine oxidase is a complex enzyme system, widely distributed throughout the body. Drugs that inhibit monoamine oxidase in the laboratory are associated with a number of clinical effects. Thus, it is unknown whether MAO inhibition per se, other pharmacologic actions, or an interaction of both is responsible for the clinical effects observed. All…

NAPROSYN® Roche Naproxen Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Naproxen has demonstrated anti-inflammatory, analgesic and antipyretic properties in classical animal test systems. In patients with rheumatoid arthritis, the anti-inflammatory action has been shown by a reduction in joint swelling, pain, and duration of morning stiffness, and by enhanced grip strength and increased mobility. It exhibits an anti-inflammatory effect even in adrenalectomized animals, and therefore its action is not mediated…

NADOSTINE® Preparations Nadeau Nystatin Antifungal – Antibiotic Indications And Clinical Uses: Oral Suspension: Prevention and treatment of candidal infections of the mouth (thrush) and intestinal candidiasis in infants and children. Oral Tablets: Prevention and treatment of oral, esophageal and intestinal candidiasis. Protection against candidal overgrowth during antibiotic and/or corticosteroid therapy. Topical Products: Treatment of mucocutaneous candidiasis. The cream is usually used to treat intertriginous areas. Vaginal Products: Local treatment of…

MSD® ENTERIC COATED ASA Johnson & Johnson Merck ASA Nonsteroidal Anti-inflammatory – Analgesic – Platelet Aggregation Inhibitor Action And Clinical Pharmacology: ASA has analgesic, antipyretic and anti-inflammatory properties. In rheumatic diseases, although the analgesic and antipyretic effects are useful, the major purpose for which ASA is used is to reduce the intensity of the inflammatory process. Inhibition of prostaglandin synthesis may be involved in the anti-inflammatory action of ASA. ASA…

MOTRIN® IB McNeil Consumer Products Ibuprofen Analgesic – Antipyretic – Anti-inflammatory Action And Clinical Pharmacology: Ibuprofen is a member of the class of agents commonly known as nonsteroidal anti-inflammatory drugs (NSAIDs). Consistent with this classification, ibuprofen exhibits anti-inflammatory activity at higher dosage ranges. At lower adult single doses relevant to a 200 mg dosage strength (200 to 400 mg) ibuprofen relieves pain of mild to moderate intensity and reduces fever….

MOTRIN® Pharmacia & Upjohn Ibuprofen Anti-inflammatory – Analgesic – Antipyretic Action And Clinical Pharmacology: Ibuprofen has demonstrated anti-inflammatory, analgesic and antipyretic activity in animal studies designed to specifically demonstrate these effects. Its mode of action, like that of other nonsteroidal anti-inflammatory agents, is not completely understood, but may be related to prostaglandin synthetase inhibition. Ibuprofen does not alter the course of the underlying disease. Ibuprofen has no demonstrable glucocorticoid effect….