Nadostine (Nystatin)

NADOSTINE® Preparations

Nadeau

Nystatin

Antifungal – Antibiotic

Indications And Clinical Uses: Oral Suspension: Prevention and treatment of candidal infections of the mouth (thrush) and intestinal candidiasis in infants and children.

Oral Tablets: Prevention and treatment of oral, esophageal and intestinal candidiasis. Protection against candidal overgrowth during antibiotic and/or corticosteroid therapy.

Topical Products: Treatment of mucocutaneous candidiasis. The cream is usually used to treat intertriginous areas.

Vaginal Products: Local treatment of vaginal candidiasis.

Contra-Indications: Hypersensitivity to nystatin or any other components of these preparations.

Precautions: Nystatin exhibits no appreciable activity against bacteria, protozoa or viruses. Discontinue medication if irritation occurs with topical or intravaginal use.

Take appropriate measures to avoid possible reinfection during sexual intercourse.

Pregnancy: Use of the vaginal applicator may not be considered desirable during pregnancy.

Adverse Reactions: Large oral doses have occasionally produced diarrhea, gastrointestinal disorders, nausea or vomiting. Local or intravaginal irritation occurs rarely. tag_DosageDosage

Dosage And Administration: Oral Suspension: Infants: Usual prophylactic and therapeutic dose is 100 000 units 4 times daily. May be dropped directly on the tongue by means of the calibrated dropper, or may be mixed with milk, lukewarm formula or other non acid vehicles. Thrush prevention in infants: 100 000 units daily. Children and adults: Usual therapeutic dose is 100 000 units 4 times daily, dropped into the mouth by means of the calibrated dropper, and held for some time before swallowing.

Oral Tablets: Usual prophylactic and therapeutic dose is 500 000 units 3 times a day. Double dosage if necessary for adults.

Ointment and Topical Cream: Apply to affected area 1 to 4 times daily as required.

Vaginal Tablets and Vaginal Cream: Insert deeply into the vagina 1 tablet (100 000 units) or 4 g (100 000 units) of cream once or twice daily by means of the applicator. Continue treatment for 2 weeks or more if necessary. Continue administration during menstruation.

Adjunctive measures such as therapeutic douches are unnecessary and sometimes inadvisable. Cleansing douches may be used by nonpregnant women, if desired, for esthetic purposes.

Pregnant patients with monilial infections should receive a dosage of 1 vaginal tablet or 4 g of vaginal cream once or twice daily for 3 to 6 weeks before term to prevent thrush in the newborn.

Nystatin therapeutic administration should generally be continued for at least 48 hours after clinical cure to prevent relapse. Oral nystatin should be prescribed at least as long as the oral antibacterial agent when these two medications are given concomitantly. Local treatment of chronic or resistant vaginal, oral or cutaneous candidiasis may be supplemented with oral nystatin administration.

Availability And Storage:

  • Oral Suspension: Each mL of banana flavored yellow suspension contains: nystatin 100 000 units. Energy: 55.25 kJ (13.0 kcal)/5 mL. Bottles of 25, 50 and 100 mL with calibrated dropper. Bottles of 500 mL. Oral Suspension (sucrose-free) : Each mL of cherry flavored yellow suspension contains: nystatin 100 000 units. Energy: 8.9 kJ (2.1 kcal)/5 mL. Sweetening agents: sorbitol and sodium saccharine. Bottles of 50 and 100 mL with calibrated dropper;
  • Oral Tablets: Each round, brown, film coated tablet contains: nystatin 500 000 units. Energy: 1.81 kJ (0.43 kcal). Bottles of 100;
  • Topical Cream: Each g of homogeneous, yellow, water soluble cream contains: nystatin 100 000 units. Tubes of 15 and 30 g. Jars of 500 g;
  • Topical Ointment: Each g of homogeneous, yellow ointment contains: nystatin 100 000 units. Tubes of 15 g;
  • Vaginal Cream : Each g of homogeneous, yellow, water soluble cream contains: nystatin 25 000 units. Tubes 120 g with calibrated applicator;
  • Vaginal Tablets: Each yellow, diamond shaped tablet contains: nystatin 100 000 units. Boxes of 15 and 30 in aluminum foil with applicator.

NADOSTINE┬« Preparations Nadeau Nystatin Antifungal – Antibiotic

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