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MIGRANAL® Novartis Pharmaceuticals Dihydroergotamine Mesylate Migraine Therapy Action And Clinical Pharmacology: Dihydroergotamine displays agonist activity at the 5-HT1D receptor, which, by reducing 5-HT neuronal function and/or contracting elements of the cranial vasculature and/or suppressing neurogenic inflammation, is believed to underlie its antimigraine efficacy. It also displays affinity for the 5-HT1C receptor and antagonistic activity at the 5-HT2 subtype. Dihydroergotamine displays blocking actions at alpha adrenoreceptors, with a direct stimulating effect…

MIN-OVRAL® 21 MIN-OVRAL® 28 Wyeth-Ayerst Levonorgestrel – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Although the primary mechanism of action is inhibition of ovulation, the effectiveness of Min-Ovral may also result from other mechanisms of action, such as hostility of the cervical mucus to sperm penetration and migration. Indications And Clinical Uses: Conception control. Contra-Indications: History of/or actual thrombophlebitis or thromboembolic disorders; history of/or actual cerebrovascular disorders; history of/or…

MIDAMOR® MSD Amiloride HCl Antikaliuretic – Diuretic Action And Clinical Pharmacology: Amiloride is an antikaliuretic drug with mild natriuretic diuretic and antihypertensive activity. The activities may be additive to the effects of thiazides or other saluretic-diuretic agents. The principal use is to conserve potassium in selected patients receiving kaliuretic-diuretic agents. Amiloride interferes with the mechanism involved in the exchange of sodium for potassium in the distal convoluted tubule and collecting…

METRETON® Schering Prednisone Acetate – Chlorpheniramine Maleate – Ascorbic Acid Glucocorticoid – Antihistamine Action And Clinical Pharmacology: Metreton combines the anti-inflammatory and antiallergic effects of the corticosteroid prednisone with the antihistaminic activity of chlorpheniramine. In addition, Metreton tablets contain ascorbic acid. By using prednisone and chlorpheniramine in combination, comparable results usually are obtained with smaller amounts of corticosteroid than when the corticosteroid is given alone. Indications And Clinical Uses: For…

METRONIDAZOLE General Monograph Antibacterial – Antiprotozoal Pharmacology: Metronidazole is amebicidal, trichomonacidal and bactericidal. A chemically reactive, reduced form of metronidazole is thought to be responsible for the drug’s activity. The reduced substrate affects anoxic or hypoxic cells causing loss of the helical structure of DNA, strand breakage and impairment of cellular function. The spectrum of activity of metronidazole includes the following: Anaerobic gram-negative bacilli, including most Bacteroides species, Fusobacterium and…

METHOTREXATE TABLETS USP Faulding Antimetabolite Action And Clinical Pharmacology: Methotrexate is an antimetabolite which competitively inhibits the enzyme folic acid reductase. During DNA synthesis and cellular reproduction, folic acid is reduced to tetrahydrofolic acid by the enzyme folic acid reductase. By interfering with the reduction of folic acid, methotrexate interferes with tissue cell reproduction. Generally, the most sensitive cells to the antimetabolite effect of methotrexate are those cells which are…

METIMYD® Schering Prednisolone – Sulfacetamide Compound Ophthalmic Corticosteroid – Antibacterial Indications And Clinical Uses: Inflammatory and allergic disease of the eye especially when antibacterial effect is desired. Contra-Indications: Tuberculosis, fungal and most viral lesions of the eye (herpes simplex/dendritic keratitis): vaccinia; varicella; acute purulent conjunctivitis and acute purulent blepharitis and in those persons who have shown hypersensitivity to any of its components. Precautions: Extended use of topical steroid therapy may…

MESTINON® MESTINON®-SR ICN Pyridostigmine Bromide Antimyasthenic – Cholinergic Action And Clinical Pharmacology: Pyridostigmine is a cholinergic agent which acts primarily by the inhibition of cholinesterase. It enhances cholinergic action by facilitating the transmission of impulses across neuromuscular junctions. It also has a direct cholinomimetic effect on skeletal muscle and possibly on autonomic ganglion cells and neurons of the CNS. Because of its quaternary ammonium structure, moderate doses of pyridostigmine do…

METANDREN® Novartis Methyltestosterone Oral Androgen Indications And Clinical Uses: In the male: replacement therapy in hypogonadism, eunuchoidism, the climacteric, and other conditions due to loss, atrophy or hypofunction of the testes. In the female: palliation of androgen-responsive, advancing, inoperable breast cancer in women who are more than 1 year, but less than 5 years, postmenopausal or who have been proven to have a hormone dependent tumor, as shown by previous…

MERREM® Zeneca Meropenem Antibiotic Action And Clinical Pharmacology: Meropenem is a broad spectrum, b-lactamase-resistant, carbapenem antibiotic for parenteral administration. The bactericidal activity of meropenem results from the inhibition of bacterial cell wall synthesis. Meropenem readily penetrates through the cell wall of most gram-positive and gram-negative bacteria to reach penicillin binding protein (PBP) targets. Its greatest affinity is for PBP 2 of E. coli, PBP 2 and 3 of P. aeruginosa…