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NOZINAN® Rhône-Poulenc Rorer Methotrimeprazine Neuroleptic Action And Clinical Pharmacology: Methotrimeprazine possesses antipsychotic, tranquilizing, anxiolytic, sedative and analgesic properties and it is also a potent potentiator of anesthetics. Methotrimeprazine possesses strong sedative properties. It potentiates ether and hexobarbital anesthesia as well as morphine analgesia. It also exerts a potent anti-apomorphine effect, a hypothermic action 3 times more potent than that of chlorpromazine and strong antispasmodic and anti-histaminic effects. Methotrimeprazine is capable…

NUMORPHAN® DuPont Pharma Oxymorphone HCl Analgesic Action And Clinical Pharmacology: Oxymorphone is a potent narcotic analgesic. When administered parenterally, 1 mg is approximately equivalent in analgesic activity to 10 mg of morphine sulfate. The onset of action of parenterally injected oxymorphone is rapid and the initial effects are usually perceived within 5 to 10 minutes, with analgesia persisting for approximately 3 to 6 hours. Oxymorphone is conjugated with glucuronic acid…

NOVO-VERAMIL SR Novopharm Verapamil HCl Antiarrhythmic – Antianginal – Antihypertensive Antihypertensive Action And Clinical Pharmacology: Angina and Arrhythmia: Verapamil, a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist) is believed to exert its antiarrhythmic and antianginal effects by selectively inhibiting transmembrane influx of calcium ions in cardiac muscle, coronary and systemic arteries and in cells of the intracardiac conduction system. Verapamil blocks the transmembrane influx of calcium…

NOVOLIN®GE Preparations Novo Nordisk Insulin Human (Biosynthetic) Antidiabetic Agent Action And Clinical Pharmacology: Novolin®ge Biosynthetic Human Insulin is a polypeptide structurally identical to natural human insulin. Novolin®ge is produced by recombinant DNA technology, using Saccharomyces cerevisiae (baker’s yeast). The content of immunoreactive peptides derived from the used microorganism (yeast) is undetectable (less than 1 ppm by weight of the dry insulin) as determined by enzyme linked immunoabsorbent assay. When administered…

NOVANTRONE® Wyeth-Ayerst Mitoxantrone HCl Antineoplastic Action And Clinical Pharmacology: Although its mechanism of action has not been determined, mitoxantrone is a DNA-reactive agent. It induces nuclear aberrations with chromosome scattering in cell cultures (human colon carcinoma line) and is a potent inhibitor of RNA and DNA synthesis. Compared on an equimolar basis, mitoxantrone is 7 times more potent than doxorubicin in inhibiting the uptake of -uridine and 4 times more…

NOVAHISTEX® DM NOVAHISTEX® DM Decongestant NOVAHISTEX® DM Decongestant Expectorant NOVAHISTINE® DM NOVAHISTINE® DM Decongestant NOVAHISTINE® DM Decongestant Expectorant Hoechst Marion Roussel Dextromethorphan HBr Dextromethorphan HBr – Pseudoephedrine HCl Dextromethorphan HBr – Pseudoephedrine HCl – Guaifenesin Dextromethorphan HBr Dextromethorphan HBr – Pseudoephedrine HCl Dextromethorphan HBr – Pseudoephedrine HCl – Guaifenesin Antitussive Antitussive – Decongestant Antitussive – Decongestant – Expectorant Antitussive Antitussive – Decongestant Antitussive – Decongestant – Expectorant Action And Clinical…

NORPRAMIN® Hoechst Marion Roussel Desipramine HCl Antidepressant Action And Clinical Pharmacology: Desipramine displays an antidepressant property similar to that of other tricyclic antidepressants. It is the active “in vivo” metabolite of imipramine and as such, shares many of imipramine’s pharmacologic effects. The anticholinergic actions of desipramine are responsible for many of the commonly observed side effects of the drug. Desipramine causes ECG changes such as prolongation of the P-R interval…

NOVA-T Berlex Canada Intrauterine Copper Intrauterine Contraceptive Description: Nova-T is an intrauterine device made of plastic (polyethylene) approximately in the shape of a T. Polyethylene threads are attached to the lower portion. The horizontal and vertical arms of the T are 32 mm in length and 1.2 mm in diameter; a loop 2.6 mm wide is found at the tip of the vertical arm; and a thin copper wire (107-141…

NORPLANT® Wyeth-Ayerst Levonorgestrel Contraceptive Implant Action And Clinical Pharmacology: Norplant consists of levonorgestrel implants, a set of 6 flexible closed capsules made of Silastic (dimethylsiloxane/methylvinylsiloxane copolymer) each containing 36 mg of the progestin levonorgestrel. Levonorgestrel, 18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,(17a)-(-)-, is a totally synthetic and biologically-active progestin which exhibits no significant estrogenic activity and is highly progestational. The absolute configuration conforms to that of D-natural steroids. Levonorgestrel is not subjected to a “first-pass” effect…

NORINYL® 1/50 Searle Norethindrone – Mestranol Oral Contraceptive Action And Clinical Pharmacology: Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness. Indications And Clinical Uses: Prevention of pregnancy. Contra-Indications: History of or actual thrombophlebitis or thromboembolic…