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APO®-MOCLOBEMIDE Apotex Moclobemide Antidepressant Action And Clinical Pharmacology: Moclobemide is a short-acting, reversible inhibitor of monoamine oxidase type A (RIMA). It is a benzamide derivative which inhibits the deamination of serotonin, noradrenaline and dopamine. This action leads to increased concentrations of these neurotransmitters, which may account for the antidepressant activity of moclobemide. Monoamine oxidases are currently subclassified into 2 types, A and B, which differ in their substrate specificity. Moclobemide…

APO®-CROMOLYN Apotex Sodium Cromoglycate Seasonal Rhinitis Prophylaxis Action And Clinical Pharmacology: In the immediate allergic reaction (Type I) the union of antigen with reaginic antibody leads to the formation and release of spasmogens and other mediators of the anaphylactic reaction. Sodium cromoglycate appears to block a step in the chain of events triggered by this union. This property accounts for the prophylactic rather than symptomatic approach to the management of…

APO®-CROMOLYN STERULES Apotex Cromolyn Sodium Asthma Prophylaxis Action And Clinical Pharmacology: In vitro and in vivo animal studies have shown that cromolyn sodium inhibits sensitized mast cell degranulation which occurs after exposure to specific antigens. It acts by inhibiting the release of mediators from mast cells. Studies show that cromolyn sodium indirectly blocks calcium ions from entering the mast cell, thereby preventing mediator release. Cromolyn sodium inhibits both the immediate…

ANUSOL® ANUSOL® PLUS Warner-Lambert Consumer Healthcare Zinc Sulfate Monohydrate Pramoxine HCl – Zinc Sulfate Monohydrate Anorectal Therapy Indications And Clinical Uses: Symptomatic relief of pain and discomfort as in: external and internal hemorrhoids, proctitis, papillitis, cryptitis, fissures, incomplete fistulas and relief of local pain following anorectal surgery. Contra-Indications: History of sensitivity to any component. Precautions: In case of rectal bleeding, consult physician promptly. Adverse Reactions: An occasional patient may experience…

ANUSOL® ANUSOL® PLUS Warner-Lambert Consumer Healthcare Zinc Sulfate Monohydrate Pramoxine HCl – Zinc Sulfate Monohydrate Anorectal Therapy Indications And Clinical Uses: Symptomatic relief of pain and discomfort as in: external and internal hemorrhoids, proctitis, papillitis, cryptitis, fissures, incomplete fistulas and relief of local pain following anorectal surgery. Contra-Indications: History of sensitivity to any component. Precautions: In case of rectal bleeding, consult physician promptly. Adverse Reactions: An occasional patient may experience…

  APO®-ACYCLOVIR Apotex Acyclovir Antiviral Agent Action And Clinical Pharmacology: Acyclovir, a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster specified thymidine kinase. Acyclovir is a poor substrate for host cell-specified thymidine kinase. Herpes simplex and varicella-zoster specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and…

APO®-CEFACLOR Apotex Cefaclor Antibiotic Action And Clinical Pharmacology: Like other b-lactam antibiotics, cefaclor owes its antibacterial activity to its ability to bind to and inhibit the action of certain bacterial cell wall synthetic enzymes, the penicillin-binding proteins. Cefaclor is well absorbed after oral administration to fed and fasted subjects. Following doses of 250 mg, 500 mg, and 1 g to fasted subjects, average peak serum levels of approximately 7, 13…

ANTIBIOTIC COLD SORE OINTMENT Novartis Consumer Health Polymyxin B Compound Cold Sore Therapy Indications And Clinical Uses: Symptomatic treatment of cold sores and fever blisters. Prevention of secondary bacterial infection. Contra-Indications: Hypersensitivity to any of the components. Manufacturers’ Warnings In Clinical States: It is dangerous to apply any product containing menthol or camphor to the nostrils of an infant. To do so may cause difficulty in breathing and collapse. Precautions:…

  ANTIPHLOGISTINE RUB A-535 Carter Horner Methyl Salicylate – Camphor – Menthol – Eucalyptus Oil Topical Analgesic Indications And Clinical Uses: External counterirritant cream for temporary pain relief of stiff and sore muscles, backache, strains, arthritic and rheumatic pain, sciatica, lumbago and bursitis. Contra-Indications: Salicylate hypersensitivity. Precautions: For external use only. Do not apply to wounds or damaged skin and avoid contact with eyes and mucous membranes. Discontinue use if…

ANTIVERT™ Pfizer Meclizine HCl – Nicotinic Acid Vertigo Therapy Action And Clinical Pharmacology: Meclizine has antihistaminic and anticholinergic properties. Nicotinic acid is a vasodilator agent which has been found effective in the treatment of vertigo due to cerebral arteriosclerosis. The site and mechanism of action of meclizine in controlling vertigo arising from various conditions, have not been clearly defined. Pharmacological studies conducted with other antihistamines show that the peripheral labyrinthine…