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ANDROCUR® ANDROCUR® DEPOT Berlex Canada Cyproterone Acetate Antiandrogen Action And Clinical Pharmacology: Cyproterone is a steroid which clinically demonstrates 2 distinct properties: Antiandrogenic: Cyproterone blocks the binding of dihydrotestosterone – the active metabolite of testosterone – to the specific receptors in the prostatic carcinoma cell. Progestogenic/antigonadotrophic: Cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of LH leading to diminished production of testicular testosterone. The absorption…

ANDRIOL Organon Testosterone Undecanoate Androgen Action And Clinical Pharmacology: Testosterone undecanoate, an orally active testosterone preparation, is a fatty acid ester of the natural androgen testosterone. Unlike other oral testosterone preparations, testosterone undecanoate is able to by-pass the liver via the lymphatic system and is therefore orally bioavailable. Therapy with Andriol increases plasma levels of testosterone and its active metabolites, leading to a regular therapeutic effect. In eugonadal men, peak…

ANECTINE® Glaxo Wellcome Succinylcholine Chloride Neuromuscular Blocking Agent Action And Clinical Pharmacology: Succinylcholine is an ultra short-acting depolarizing-type, skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. Onset of flaccid paralysis is rapid, (less than…

ANCEF® SmithKline Beecham Cefazolin Sodium Antibiotic Action And Clinical Pharmacology: Cefazolin sodium is a cephalosporin antibiotic for parenteral administration. It exerts its bactericidal action through inhibition of bacterial cell wall synthesis. Indications And Clinical Uses: In the treatment of the following infections when caused by susceptible strains of the following organisms: Respiratory tract infections caused by S. pneumoniae (formerly D. pneumoniae), K. pneumoniae, H. influenzae, S. aureus (penicillin-sensitive and penicillin-resistant)…

ANBESOL® Preparations Whitehall-Robins Benzocaine Compound Topical Anesthetic Indications And Clinical Uses: Anbesol: For temporary pain relief of toothache, denture irritation, brace pain, minor mouth irritations, cold sores, sun and fever blisters and canker sores. Anbesol Baby: For temporary relief from the pain and irritation associated with teething. Contra-Indications: Anbesol: Known sensitivity to any of the ingredients. Anbesol Baby: Known sensitivity to any of the ingredients. Precautions: Not for prolonged use….

ANACIN® ANACIN® EXTRA STRENGTH Whitehall-Robins ASA – Caffeine Analgesic – Antipyretic – Anti-inflammatory Indications And Clinical Uses: For fast relief of headaches, aches and fever of colds, arthritic and rheumatic pain, toothache and menstrual pain. Contra-Indications: Sensitivity to salicylates, bleeding ulcers and patients with blood coagulation defects, hemophilia, anemia, vitamin K deficiency, renal function impairment, asthma, sensitivity to caffeine and cardiac disease. Manufacturers’ Warnings In Clinical States: All salicylates should…

ANALGESIC BALM Warner-Lambert Consumer Healthcare Menthol – Methyl Salicylate Topical Analgesic Indications And Clinical Uses: For the local treatment of muscular and joint pains. Contra-Indications: Any sensitivity to the components. Precautions: Avoid contact with eyes, mucous membranes or broken skin. Keep out of reach of children. In case of accidental swallowing, seek medical advice. Dosage: Apply by thoroughly rubbing into the skin to promote absorption. To prolong the effect, cover…

ANAFRANIL® Novartis Pharmaceuticals Clomipramine HCl Antidepressant – Antiobsessional Action And Clinical Pharmacology: Clomipramine is a tricyclic agent with both antidepressant and antiobsessional properties. Like other tricyclics, clomipramine inhibits norepinephrine and serotonin uptake into central nerve terminals, possibly by blocking the membrane-pump of neurons, thereby increasing the concentration of transmitter monoamines at receptor sites. Clomipramine is presumed to influence depression and obsessive and compulsive behavior through its effects on serotonergic neurotransmission….

AMOXICILLIN Amoxycillin Antibiotic Pharmacology: Amoxicillin, a semisynthetic penicillin of the aminopenicillin group, is bactericidal against sensitive organisms. It acts through the inhibition of mucopeptide synthesis in the bacterial cell wall. The spectrum of activity of amoxicillin includes H. influenzae, E. coli, P. mirabilis, Salmonella and some Shigella species while also retaining activity against penicillin-sensitive gram-positive bacteria (see Penicillin G/Penicillin V, General Monograph). However, many Enterobacteriaceae, H. Influenzae, Salmonella and Shigella…

AMPICIN® Bristol Ampicillin Sodium Antibiotic Action And Clinical Pharmacology: Ampicillin is a broad-spectrum penicillin, indicated for the treatment of a wide range of bacterial infections caused by ampicillin-sensitive organisms. Ampicillin is similar to benzyl penicillin in its bactericidal action against susceptible organisms during the stage of active multiplication. It acts through the inhibition of cell wall mucopeptide biosynthesis. Ampicillin has a broad spectrum of bactericidal activity against many gram-positive and…