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CIPRO® CIPRO® I.V. CIPRO® Oral Suspension Bayer Ciprofloxacin HCl Ciprofloxacin Ciprofloxacin Antibacterial Action And Clinical Pharmacology: Ciprofloxacin, a synthetic fluoroquinolone, has a bactericidal mode of action. This action is achieved through inhibition of DNA gyrase, an essential component of the bacterial DNA replication system. Inhibition of the alpha subunit of the DNA gyrase blocks the resealing of the nicks on the DNA strands induced by this alpha subunit, leading to…

CHOLEDYL® SA Parke-Davis Oxtriphylline Bronchodilator Action And Clinical Pharmacology: Oxtriphylline is the theophylline salt of choline and contains 64% theophylline with the properties attributed to it. Choledyl SA is a sustained release tablet which produces peak blood levels of theophylline (8 to 12 g/mL) between 2 and 4 hours. Once the steady-state level has been reached, the therapeutic blood levels persist for 12 hours. Indications And Clinical Uses: For maintenance…

CHOLOXIN® Knoll hyper Hypolipidemic Thyroactive Agent Action And Clinical Pharmacology: Dextrothyroxine reduces serum cholesterol levels in hyperlipidemic patients. Beta lipoprotein and triglyceride fractions may also be reduced from previously elevated levels. Dextrothyroxine stimulates the liver to increase catabolism and excretion of cholesterol and its degradation products via the biliary route into the feces. Cholesterol synthesis is not inhibited and abnormal metabolic end-products do not accumulate in the blood. Indications And…

CHOLECYSTOKININ Ferring Diagnostic Cholecystokinetic Action And Clinical Pharmacology: Cholecystokinin (CCK) is a natural polypeptide, formed in the APUD cells of the proximal mucosa of the small intestine. It stimulates secretion of pancreatic digestive enzymes, the flow of bile and the secretion from the glands of Brunner. It stimulates contraction of the gallbladder, inhibits contraction of the lower esophageal sphincter and the sphincter of Oddi and increases motility of the stomach…

CHOLEDYL® EXPECTORANT Parke-Davis Oxtriphylline – Guaifenesin Bronchodilator – Expectorant Action And Clinical Pharmacology: Oxtriphylline contains 64% theophylline and has the properties attributed to theophylline. tag_IndicationsIndications Indications And Clinical Uses: The symptomatic treatment of reversible bronchoconstriction associated with chronic obstructive pulmonary emphysema, bronchial asthma, chronic bronchitis and related bronchospastic disorders and where expectoration is required. Precautions: Patients starting therapy should be carefully observed to determine if this fixed dose combination is…

CHOLEDYL® Parke-Davis Oxtriphylline Bronchodilator Action And Clinical Pharmacology: Oxtriphylline contains 64% theophylline and has the properties attributed to theophylline. Indications And Clinical Uses: The symptomatic treatment of reversible bronchoconstriction associated with bronchial asthma, chronic obstructive pulmonary emphysema, chronic bronchitis and related bronchospastic disorders. Contra-Indications: Hypersensitivity to xanthines; active peptic ulcer; in coronary artery disease when myocardial stimulation might prove harmful. Precautions: Parents should be cautioned against overdosage to children –…

CEREBYX® Parke-Davis Fosphenytoin Sodium Antiepileptic Action And Clinical Pharmacology: Introduction: Following parenteral administration of fosphenytoin, fosphenytoin is converted to the anticonvulsant phenytoin. For every mmol of fosphenytoin administered, 1 mmol of phenytoin is produced. The pharmacological and toxicological effects of fosphenytoin include those of phenytoin. However, the hydrolysis of fosphenytoin to phenytoin yields 2 metabolites, phosphate and formaldehyde. Formaldehyde is subsequently converted to formate, which is in turn metabolized via…

CERUMENEX® Purdue Frederick Triethanolamine Polypeptide Oleate-condensate Cerumenolytic Indications And Clinical Uses: For removal of impacted cerumen. Cleansing prior to aural examination, treatment, or audiometry. Should not be used for routine wax removal or cleaning of the ears. Contra-Indications: Perforated eardrum. Middle ear infection or severe inflammatory or atopic dermatitis in the external ear. Positive patch test. History of untoward reaction to Cerumenex. Precautions: Should be used with extreme caution in…

CELONTIN® Parke-Davis Methsuximide Anticonvulsant Action And Clinical Pharmacology: Methsuximide elevates seizure threshold in the cortex and basal ganglia and reduces synaptic response to low frequency repetitive stimulation. The peroxisomal spike and wave pattern of the EEG, common in petit mal seizure, is suppressed. Pharmacokinetics: Methsuximide is absorbed from the gastrointestinal tract and peak plasma levels are achieved in 1 to 3 hours. The plasma half-life of methsuximide is slightly less…

CEFTIN® Glaxo Wellcome Cefuroxime Axetil Antibiotic Action And Clinical Pharmacology: Cefuroxime axetil is an orally active prodrug of cefuroxime. After oral administration, cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed by nonspecific esterases in the intestinal mucosa and blood to release cefuroxime into the blood stream. Conversion to cefuroxime, the microbiologically active form, occurs rapidly. The inherent properties of cefuroxime are unaltered after its administration as cefuroxime…