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DRIXORAL® N.D. Schering Pseudoephedrine Sulfate Decongestant Indications And Clinical Uses: Symptomatic relief of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis and rhinosinusitis, acute and subacute sinusitis, eustachian tube blockage and secretory otitis media. Contra-Indications: Patients receiving or having received MAO inhibitors in the preceding 2 weeks; known hypersensitivity to pressor amines or antihistamines. Precautions: Although pseudoephedrine causes practically no pressor effect in normotensive individuals, it…

DRIXORAL® DRIXTAB® Schering Dexbrompheniramine Maleate – Pseudoephedrine Sulfate Antihistamine – Decongestant Indications And Clinical Uses: Symptomatic relief of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis and rhinosinusitis, acute and subacute sinusitis, eustachian tube blockage and secretory otitis media. Contra-Indications: Patients receiving or having received MAO inhibitors in the preceding 2 weeks; known hypersensitivity to pressor amines or antihistamines. Children under 12 years of age (sustained…

COPHYLAC® Hoechst Marion Roussel Normethadone – p-Hydroxyephedrine HCl Compound Antitussive Indications And Clinical Uses: The treatment of cough associated with inflamed mucosa, which does not respond to products of lesser potency. Cophylac Expectorant is indicated to facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum which does not respond to products of lesser potency. Contra-Indications: Do not administer to patients receiving MAO inhibitors. Cophylac Expectorant is contraindicated…

COMBIVENT® Inhalation Solution Boehringer Ingelheim Ipratropium Bromide – Salbutamol Sulfate Bronchodilator Action And Clinical Pharmacology: Combivent Inhalation Solution is a combination of the anticholinergic bronchodilator, ipratropium bromide, and the beta2-adrenergic bronchodilator, salbutamol sulfate. Ipratropium bromide is a quaternary ammonium derivative of atropine and is an anticholinergic drug which has bronchodilator properties. On inhalation, the onset of action is noted within 5 to 15 minutes, with a peak response between 1…

COMPLEX 15® Schering Dimethicone – Lecithin Emollient Indications And Clinical Uses: To soothe and relieve dry, sensitive skin. Phospholipid lecithin is a water-binding agent which occurs naturally in the deepest layers of the skin. Each phospholipid molecule forms a complex of 15 water molecules creating a moisture reservoir which restores the skin’s moisture balance. Dosage: Apply as often as needed to the hands, body and face. Availability And Storage: Face…

CONDYLINE™ Canderm Pharma Podofilox Antimitotic Agent Action And Clinical Pharmacology: Necrosis of visible tissue is observed following treatment of genital warts with podofilox. The exact mechanism of action is unknown. Podofilox is believed to exert its antimitotic effect by binding to tubulin, at a site close to but not identical to the binding site of colchicine; it is thought that this antimitotic effect causes necrosis of wart tissue, the observed…

CLOPIXOL® CLOPIXOL-ACUPHASE® CLOPIXOL® DEPOT Lundbeck Zuclopenthixol Dihydrochloride Zuclopenthixol Acetate Zuclopenthixol Decanoate Antipsychotic Action And Clinical Pharmacology: Zuclopenthixol, a thioxanthene derivative, has high affinity for both dopamine D1 receptors and dopamine D2 receptors. Zuclopenthixol also has high affinity for a1-adrenergic and 5-HT2 receptors. It has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and a2-adrenergic receptors. Pharmacokinetics: The pharmacokinetics of zuclopenthixol appear to be linear over…

CLAVULIN® SmithKline Beecham Amoxicillin – Clavulanate Potassium Antibiotic – b-Lactamase Inhibitor Action And Clinical Pharmacology: Amoxicillin exerts a bactericidal action against sensitive organisms during the stage of active multiplication through the inhibition of the biosynthesis of bacterial cell wall mucopeptides. Clavulanic acid inhibits specific b-lactamases of some microorganisms and allows amoxicillin to inhibit amoxicillin (ampicillin) resistant organisms which produce clavulanic acid sensitive b-lactamases. Indications And Clinical Uses: For the treatment…

CLAFORAN® Hoechst Marion Roussel Cefotaxime Sodium Antibiotic Action And Clinical Pharmacology: Animal studies demonstrate that cefotaxime has no significant effect on the CNS, cardiovascular and respiratory systems, kidneys, blood clotting mechanisms and blood glucose levels. There is a dose-dependent increase in serum levels after i.v. administration of 500 mg, 1 and 2 g of cefotaxime (38.9, 101.7 and 214.4 g/mL respectively), without alteration in the elimination half-life. The biological half-life…

CILOXAN® Alcon Ciprofloxacin HCl Antibacterial Agent Action And Clinical Pharmacology: The bactericidal action of ciprofloxacin results from inhibition of the enzyme, DNA gyrase, which is required for the synthesis of bacterial DNA. Pharmacokinetics: Topically applied ciprofloxacin ophthalmic solution is absorbed systemically with ciprofloxacin plasma concentrations approaching steady state at the end of dosing each day. Ciprofloxacin plasma concentrations following a routine ophthalmic treatment regimen were in the range of nonquantifiable…