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DEMADEX® Roche Torsemide Diuretic – Antihypertensive Action And Clinical Pharmacology: Mechanism of Action: Micropuncture studies in animals have shown that torsemide acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the NaK2Clcarrier system. Clinical pharmacology studies have confirmed this site of action in humans, and effects in other segments of the nephron have not been demonstrated. Diuretic activity thus correlates better…

DDAVP® Tablets Ferring Desmopressin Acetate Antidiuretic Action And Clinical Pharmacology: Desmopressin is a synthetic structural analogue of the antidiuretic hormone, arginine vasopressin, which alters the permeability of the renal tubule to increase resorption of water. The increase in the permeability of both the distal tubules and collecting ducts appears to be mediated by a stimulation of the adenylcyclase activity in the renal tubules. Although the bioavailability of orally ingested desmopressin…

DECADRON® Tablets MSD Dexamethasone Corticosteroid Indications And Clinical Uses: Allergic States: Control of severe or incapacitating allergic conditions not responsive to adequate trials of conventional treatment: seasonal or perennial allergic rhinitis, bronchial asthma, contact dermatitis, atopic dermatitis, serum sickness, drug hypersensitivity reactions. Rheumatic Disorders: as adjunctive therapy for short-term administration during an acute episode or exacerbation of: psoriatic arthritis, rheumatoid arthritis including juvenile rheumatoid arthritis (selected cases may require low-dose…

DAUNOXOME® NeXstar Liposomal Daunorubicin Antineoplastic Action And Clinical Pharmacology: DaunoXome is a liposomal preparation of daunorubicin formulated to selectively target daunorubicin to solid tumors in situ. While in the circulation, this formulation protects the entrapped daunorubicin from chemical and enzymatic degradation, minimizes protein binding, and generally decreases uptake by normal tissues, as well as by the non-reticuloendothelial system. The specific mechanism by which DaunoXome is able to deliver daunorubicin to…

DARVON-N® Lilly Propoxyphene Napsylate Analgesic Indications And Clinical Uses: For the relief of mild to moderate pain alone or when it is accompanied by fever. Contra-Indications: Hypersensitivity to any of the components Manufacturers’ Warnings In Clinical States: Do not prescribe propoxyphene for patients who are suicidal or addiction-prone. Prescribe propoxyphene with caution for patients taking tranquilizers or antidepressant drugs and patients who use alcohol in excess. Tell your patients not…

DAYPRO™ Searle Oxaprozin Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Oxaprozin is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. The modes of action of oxaprozin, like that of other nonsteroidal anti-inflammatory agents, are not fully established. It is known, however, that it does inhibit prostaglandin synthesis. Pharmacokinetics: Oxaprozin is almost completely absorbed from the gastrointestinal tract, with peak plasma levels attained 2 to 4 hours after administration. The…

DURICEF™ Bristol Cefadroxil Antibiotic Action And Clinical Pharmacology: Cefadroxil is a cephalosporin with bactericidal activity. In vitro studies have shown that the antibacterial activity of the cephalosporins results from their ability to inhibit mucopeptide synthesis in the bacterial cell wall. Pharmacokinetics: Cefadroxil is well absorbed following oral administration with 93% of a 500 mg dose being recovered unchanged in the urine after 24 hours. Absorption of cefadroxil from the gastrointestinal…

DULCOLAX® Boehringer Ingelheim Self Medication Division Bisacodyl Laxative Indications And Clinical Uses: For the treatment of occasional constipation. In the preparation for diagnostic procedures, in pre- and postoperative treatment, and in conditions which require defecation to be facilitated, the use of bisacodyl must be under medical supervision. Contra-Indications: In patients with ileus, intestinal obstruction, acute surgical abdominal conditions like acute appendicitis, acute inflammatory bowel diseases, and in severe dehydration. Bisacodyl…

DRIXORAL® DAY/NIGHT Cold Relief System Schering Dexbrompheniramine – Pseudoephedrine Sulfate Antihistamine – Decongestant Indications And Clinical Uses: Symptomatic relief of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis and rhinosinusitis, acute and subacute sinusitis, eustachian tube blockage and secretory otitis media. Contra-Indications: Patients receiving or having received MAO inhibitors in the preceding 2 weeks; known hypersensitivity to pressor amines or antihistamines. Precautions: Although pseudoephedrine causes practically…

DRIXORAL® NASAL SOLUTION Schering Oxymetazoline HCl Nasal Decongestant Indications And Clinical Uses: The relief of congestion of the nasopharyngeal mucous membranes in a variety of allergic and infectious disorders of the upper respiratory tract, including acute rhinitis and nasopharyngitis; acute and chronic sinusitis; acute and chronic vasomotor rhinitis; perennial allergic rhinitis and seasonal allergic rhinitis (hay fever). Contra-Indications: Narrow angle glaucoma, rhinitis sicca. Concurrent therapy with MAO inhibitors. Hypersensitivity to…