You searched for : 'X'

METHOTREXATE SODIUM INJECTION USP Faulding Antimetabolite Action And Clinical Pharmacology: Methotrexate is an antimetabolite which competitively inhibits the enzyme folic acid reductase. During DNA synthesis and cellular reproduction, folic acid is reduced to tetrahydrofolic acid by the enzyme folic acid reductase. By interfering with the reduction of folic acid, methotrexate interferes with tissue cell reproduction. Generally, the most sensitive cells to the antimetabolite effect of methotrexate are those cells which…

MERCODOL® with DECAPRYN® Hoechst Marion Roussel Hydrocodone Bitartrate – Etafedrine HCl Sodium Citrate – Doxylamine Succinate Antihistaminic – Antitussive – Decongestant Indications And Clinical Uses: The treatment of cough associated with inflamed mucosa, which does not respond to products of lesser potency. Contra-Indications: Patients receiving MAO inhibitors, sensitivity to any of the components. Precautions: Before prescribing medication to suppress or modify cough, it is important to ascertain that the underlying cause…

MEFOXIN® MSD Cefoxitin Sodium Antibiotic Action And Clinical Pharmacology: In vitro studies demonstrate that the bactericidal action of cefoxitin, a cephamycin derived from cephamycin C, results from the inhibition of bacterial cell wall synthesis. Evidence suggests that the methoxy group in the 7a position is responsible for the resistance of cefoxitin to degradation by bacterial beta-lactamases. Cefoxitin is poorly absorbed orally in humans. Cefoxitin, administered parenterally, produces high serum and…

MAXERAN® Hoechst Marion Roussel Metoclopramide HCl Modifier of Upper Gastrointestinal Tract Motility – Antiemetic Action And Clinical Pharmacology: Metoclopramide is a benzamide derivative, structurally related to procainamide and sulpiride. As with sulpiride, it has dopamine-antagonist activity with selective affinity for D-2 (non-adenylate cyclase-linked) receptors. The behavioral, motor, and neuroendocrine effects of metoclopramide have been linked to its antidopaminergic activity. Metoclopramide has antiemetic properties, which are believed to result from its…

MAXIPIME™ Bristol-Myers Squibb Cefepime HCl Antibiotic Action And Clinical Pharmacology: Cefepime is a semi-synthetic broad spectrum cephalosporin antibiotic intended for i.m. or i.v. administration. Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. It has a broad spectrum of activity against a wide range of gram-positive and gram-negative bacteria. The average elimination half-life of cefepime is approximately 2 hours, and does not vary with respect…

MANERIX® Roche Moclobemide Antidepressant Action And Clinical Pharmacology: Moclobemide is a short-acting, reversible inhibitor of monoamine oxidase (MAO). It is a benzamide derivative which inhibits the deamination of serotonin, norepinephrine and dopamine. This action leads to increased concentrations of these neurotransmitters, which may account for the antidepressant activity of moclobemide. MAOs are currently subclassified into 2 types, A and B, which differ in their substrate specificity. Moclobemide preferentially inhibits MAO-A;…

MACROBID® Procter & Gamble Pharmaceuticals Nitrofurantoin Monohydrate – Nitrofurantoin Macrocrystals Urinary Tract Antibacterial Action And Clinical Pharmacology: Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates which inactivate or alter bacterial ribosomal proteins and other macromolecules. As a result of such inactivations, the vital biochemical processes of protein synthesis, aerobic energy metabolism, DNA synthesis, RNA synthesis and cell wall synthesis are inhibited. The broad-based nature of this mode of action…

Indications And Clinical Uses: For the treatment and relief of the symptoms of peptic ulcer, gastritis and hyperacidity. Contraindications: hypersensitivity to active substances and other components of the drug; severe renal failure; hypophosphatemia; intolerance to fructose (due to the presence of sorbitol in the preparation); children and adolescents up to 15 years old. Precautions: Magnesium salts, in the presence of renal insufficiency, may cause CNS depression. Aluminum hydroxide, in the…

MAALOX® PLUS EXTRA STRENGTH Novartis Consumer Health Magnesium Hydroxide – Aluminum Hydroxide – Simethicone Antacid – Antiflatulent Indications And Clinical Uses: For symptomatic relief of hyperacidity, acid indigestion, heartburn and gas. Contra-Indications: Alkalosis; hypermagnesemia; where distention may be due to partial or complete intestinal obstruction. Not recommended for severely debilitated patients or those with impaired renal function. Precautions: Magnesium salts, in the presence of renal insufficiency, may cause CNS depression….

MAALOX® PLUS Novartis Consumer Health Magnesium Hydroxide – Aluminum Hydroxide – Simethicone Antacid – Antiflatulent Indications And Clinical Uses: For symptomatic relief of hyperacidity, acid indigestion, heartburn and gas. Contra-Indications: Alkalosis; hypermagnesemia; where distention may be due to partial or complete intestinal obstruction. Not recommended for severely debilitated patients or those with impaired renal function. Precautions: See Maalox monograph. Symptoms And Treatment Of Overdose: Symptoms and Treatment: See Maalox monograph….