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ANUSOL® ANUSOL® PLUS Warner-Lambert Consumer Healthcare Zinc Sulfate Monohydrate Pramoxine HCl – Zinc Sulfate Monohydrate Anorectal Therapy Indications And Clinical Uses: Symptomatic relief of pain and discomfort as in: external and internal hemorrhoids, proctitis, papillitis, cryptitis, fissures, incomplete fistulas and relief of local pain following anorectal surgery. Contra-Indications: History of sensitivity to any component. Precautions: In case of rectal bleeding, consult physician promptly. Adverse Reactions: An occasional patient may experience…

ANZEMET™ Hoechst Marion Roussel Dolasetron Mesylate Antiemetic Action And Clinical Pharmacology: Dolasetron and its active metabolite, hydrodolasetron (MDL 74156), are selective 5-HT3 receptor antagonists shown not to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is…

  APO®-ACYCLOVIR Apotex Acyclovir Antiviral Agent Action And Clinical Pharmacology: Acyclovir, a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster specified thymidine kinase. Acyclovir is a poor substrate for host cell-specified thymidine kinase. Herpes simplex and varicella-zoster specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and…

APO®-CEFACLOR Apotex Cefaclor Antibiotic Action And Clinical Pharmacology: Like other b-lactam antibiotics, cefaclor owes its antibacterial activity to its ability to bind to and inhibit the action of certain bacterial cell wall synthetic enzymes, the penicillin-binding proteins. Cefaclor is well absorbed after oral administration to fed and fasted subjects. Following doses of 250 mg, 500 mg, and 1 g to fasted subjects, average peak serum levels of approximately 7, 13…

  ANTIPHLOGISTINE RUB A-535 Carter Horner Methyl Salicylate – Camphor – Menthol – Eucalyptus Oil Topical Analgesic Indications And Clinical Uses: External counterirritant cream for temporary pain relief of stiff and sore muscles, backache, strains, arthritic and rheumatic pain, sciatica, lumbago and bursitis. Contra-Indications: Salicylate hypersensitivity. Precautions: For external use only. Do not apply to wounds or damaged skin and avoid contact with eyes and mucous membranes. Discontinue use if…

Antivenin (Latrodectus Mactans) MSD Black Widow Spider Antivenin Indications And Clinical Uses: Used to treat patients suffering from symptoms due to bites from the black widow spider. Early use of the antivenin is emphasized for prompt relief. Manufacturers’ Warnings In Clinical States: Prior to treatment with any product prepared from horse serum, a careful review of the patient’s history should be taken emphasizing prior exposure to horse serum or any…

ANTIVERT™ Pfizer Meclizine HCl – Nicotinic Acid Vertigo Therapy Action And Clinical Pharmacology: Meclizine has antihistaminic and anticholinergic properties. Nicotinic acid is a vasodilator agent which has been found effective in the treatment of vertigo due to cerebral arteriosclerosis. The site and mechanism of action of meclizine in controlling vertigo arising from various conditions, have not been clearly defined. Pharmacological studies conducted with other antihistamines show that the peripheral labyrinthine…

ANTURAN® Novartis Pharmaceuticals Sulfinpyrazone Platelet Inhibitory Agent – Uricosuric Agent – Prophylactic Agent for Reduction of Mortality Post-myocardial Infarction Action And Clinical Pharmacology: Sulfinpyrazone inhibits thrombotic processes that are associated with platelet adhesion, aggregation and reduced platelet survival. Sulfinpyrazone reduces serum urate levels, prevents formation of new tophi, and promotes resorption of existing tophi by increasing clearance of uric acid and water through the kidneys. Sulfinpyrazone has been shown to…

ANSAID® Pharmacia & Upjohn Flurbiprofen Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Flurbiprofen, a phenylalkanoic acid derivative, is a nonsteroidal anti-inflammatory agent which also possesses analgesic and antipyretic activities. Its mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. However, its therapeutic action is not due to pituitary-adrenal stimulation. Flurbiprofen is an inhibitor of prostaglandin synthesis. The resulting decrease in prostaglandin synthesis may partially explain the…

ANTABUSE® Wyeth-Ayerst Disulfiram Alcohol Deterrent Action And Clinical Pharmacology: Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage. During alcohol metabolism after disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of…