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PERSANTINE® Boehringer Ingelheim Dipyridamole Coronary Vasodilator – Inhibitor of Platelet Adhesion and Aggregation Action And Clinical Pharmacology: Dipyridamole normalizes increased platelet adhesiveness and tendency to aggregate (Hellem’s method). Dipyridamole has been found to lengthen abnormally shortened platelet survival time in a dose-dependent manner; 400 mg/day or 100 mg/day plus 1 g ASA. It is believed that platelet reactivity and interaction with prosthetic cardiac valve surfaces, resulting in abnormal shortened platelet…

PERIDEX® Zila Pharmaceuticals Chlorhexidine Gluconate Antigingivitis Action And Clinical Pharmacology: Chlorhexidine provides antimicrobial activity during oral rinsing which is maintained between rinsings. Microbiologic sampling of plaque has shown a general reduction of both aerobic and anaerobic bacterial counts ranging from 54 to 97% through 6 months’ clinical use. Rinsing with chlorhexidine inhibits the buildup and maturation of plaque by reducing certain microbes regarded as gingival pathogens, thereby reducing gingivitis. Chlorhexidine…

PERMAX® Draxis Health Pergolide Mesylate Dopamine Agonist Action And Clinical Pharmacology: Pergolide mesylate, a synthetic ergot derivative, is a dopamine receptor agonist at both D1 and D2 receptor sites. In Parkinson’s disease, pergolide is believed to exert its therapeutic effect by directly stimulating postsynaptic dopamine receptors in the corpus striatum. In addition, pergolide suppresses the secretion of prolactin, causes a transient increase in serum concentration of growth hormone and a…

PERCOCET® PERCOCET®-DEMI DuPont Pharma Oxycodone HCl – Acetaminophen Opioid Analgesic Action And Clinical Pharmacology: The principal ingredient, oxycodone, is a semisynthetic opioid analgesic with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the CNS and organs composed of smooth muscle. The principal actions of therapeutic value of the oxycodone in Percocet are analgesia and sedation. Oxycodone is similar to codeine and methadone in that…

PERCODAN® PERCODAN®-DEMI DuPont Pharma Oxycodone HCl – ASA Opioid Analgesic Action And Clinical Pharmacology: The principal ingredient, oxycodone, is a semisynthetic opioid analgesic with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the CNS and organs composed of smooth muscle. The principal actions of therapeutic value of the oxycodone in Percodan are analgesia and sedation. Oxycodone is similar to codeine and methadone in that…

PedvaxHIB® MSD Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) Vaccine Action And Clinical Pharmacology: Disease Epidemiology: Prior to the introduction of Haemophilus b conjugate vaccines, H. influenzae type b (Haemophilus b) was the most frequent cause of bacterial meningitis and a leading cause of serious systemic bacterial disease in young children worldwide. Haemophilus b disease occurred primarily in children under 5 years of age in the United States prior to…

PAXIL® SmithKline Beecham Paroxetine HCl Antidepressant – Antiobsessional – Antipanic Agent Action And Clinical Pharmacology: Paroxetine is a potent and selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor (SSRI). This activity of the drug on brain neurons is thought to be responsible for its antidepressant action as well as its efficacy in the treatment of obsessive-compulsive disorder (OCD) and panic disorder. Paroxetine is a phenylpiperidine derivative which is chemically unrelated to the…

PARVOLEX® Bioniche Acetylcysteine Mucolytic – Antidote for Acetaminophen Poisoning Action And Clinical Pharmacology: The viscosity of respiratory mucous secretions depends primarily on the content of mucoprotein and to a smaller extent on the concentration of desoxyribonucleic acid (DNA). The proportion of DNA is increased with the presence of purulent material, due to cellular debris. The mucolytic action of acetylcysteine is related to the sulphydryl group in the molecule. This group…

PARAFON FORTE® C8 Johnson & Johnson• Merck Chlorzoxazone – Acetaminophen – Codeine Phosphate Analgesic – Muscle Relaxant Action And Clinical Pharmacology: Parafon Forte C8 combines the muscle-relaxant effect of chlorzoxazone with acetaminophen, a well-known analgesic, and codeine, a centrally-acting narcotic analgesic. Chlorzoxazone is a centrally acting agent for painful musculoskeletal conditions. Data available from animal experiments, as well as human study, indicate that chlorzoxazone acts primarily at the level of…

PARAFON FORTE® Johnson & Johnson• Merck Chlorzoxazone – Acetaminophen Muscle Relaxant – Analgesic Action And Clinical Pharmacology: Parafon Forte tablets combine the muscle-relaxant effect of chlorzoxazone with acetaminophen, a well-known analgesic. Chlorzoxazone is a centrally acting agent for painful musculoskeletal conditions. Data available from animal experiments, as well as human study, indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where…