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DIOVAN® Novartis Pharmaceuticals Valsartan Angiotensin II AT1 Receptor Blocker Action And Clinical Pharmacology: Valsartan is an orally active angiotensin II AT1 receptor blocker. Valsartan acts selectively on AT1, the receptor subtype that mediates the known cardiovascular actions of angiotensin II, the primary vaso-active hormone of the renin-angiotensin-system. The AT2 receptor subtype, found in tissues such as brain, endometrium, myometrium and fetal kidney and adrenals, plays no known role in cardiovascular…

DIMETAPP®-DM Whitehall-Robins Brompheniramine Maleate – Dextromethorphan HBr – Phenylephrine HCl – Phenylpropanolamine HCl Antihistamine – Antitussive – Decongestant Indications And Clinical Uses: Symptomatic treatment of allergic manifestations of cough, nasal congestion, runny nose accompanying colds and other upper respiratory infections. Contra-Indications: Hypersensitivity to any of the components. Marked hypertension. Do not administer to patients receiving MAO inhibitors. Pregnancy: Safe use during pregnancy has not been established. Precautions: Use with care…

DIMETAPP® Whitehall-Robins Brompheniramine Maleate – Phenylephrine HCl – Phenylpropanolamine HCl Antihistamine – Decongestant Indications And Clinical Uses: Symptomatic relief of the allergic manifestations of respiratory illnesses such as the common cold, seasonal allergies, etc. Contra-Indications: Hypersensitivity to antihistamines or sympathomimetic amines. Patients receiving MAO inhibitors. Precautions: Administer with caution to patients with cardiac or peripheral vascular diseases, glaucoma, hyperthyroidism, chronic lung disease, diabetes mellitus or hypertension, prostate enlargement and bladder…

DIMETAPP®-A SINUS Whitehall-Robins Acetaminophen – Phenylephrine HCl – Phenylpropanolamine HCl Analgesic – Decongestant Indications And Clinical Uses: Control of nasal and sinus congestion, of pain associated with the common cold and sinusitis. Contra-Indications: Hypersensitivity to any of the components and patients receiving MAO inhibitors. Precautions: Do not exceed the recommended dosage. Caution is recommended for patients with hyperthyroidism, heart disease, hypertension, glaucoma, diabetes, prostate enlargement, bladder neck obstruction, liver or…

DIMETAPP®-C Whitehall-Robins Brompheniramine Maleate – Codeine Phosphate – Phenylephrine HCl – Phenylpropanolamine HCl Antihistamine – Cough Suppressant – Decongestant Indications And Clinical Uses: For the symptomatic relief of coughing, nasal congestion, runny nose, sneezing and lacrimation accompanying the common cold and other upper respiratory infections. Contra-Indications: Hypersensitivity to any of the ingredients, marked hypertension and in patients receiving MAO inhibitors. Precautions: Administer with caution to patients with cardiac or peripheral…

DIMENHYDRINATE INJECTION Astra Antiemetic Action And Clinical Pharmacology: While the precise mode of action of dimenhydrinate is not known, it has a depressant action on hyperstimulated labyrinthine functions or associated neural pathways. Indications: Prevention and relief of motion sickness and the nausea or vomiting incident to these conditions. The treatment or prophylaxis of the nausea and vomiting of radiation sickness, postoperative vomiting, and drug-induced nausea and vomiting; also for the…

DIMETANE® Whitehall-Robins Brompheniramine Maleate Antihistamine Indications And Clinical Uses: Prevention and symptomatic relief of manifestations of allergic states such as hay fever, conjunctivitis, angioneurotic edema, pruritus, rhinitis, atopic eczema, urticaria, dermatitis, drug reaction, rhus dermatitis, insect and spider bites. Contra-Indications: Hypersensitivity to antihistamines and patients receiving MAO inhibitors. Precautions: Occupational Hazards: Patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been…

DILAUDID® Knoll Hydromorphone HCl Analgesic – Antitussive Action And Clinical Pharmacology: Hydromorphone has a strong analgesic action and antitussive activity. Small doses of hydromorphone produce effective and prompt relief of pain usually with minimal nausea and vomiting. Generally, when given parenterally, hydromorphone’s analgesic action is apparent within 15 minutes and remains in effect for more than 5 hours. The onset of action of oral hydromorphone is somewhat slower, with measurable…

DILANTIN® CAPSULES Parke-Davis Phenytoin Sodium Anticonvulsant Action And Clinical Pharmacology: Phenytoin is an anticonvulsant drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient….

DILAUDID-HP® DILAUDID-HP-PLUS® DILAUDID-XP® DILAUDID® STERILE POWDER Knoll Hydromorphone HCl Opioid Analgesic Action And Clinical Pharmacology: Hydromorphone is a hydrogenated ketone of morphine. It is an opioid analgesic with many of the effects common to the class of drugs. Opioid analgesics have multiple actions but exert their primary effects on the CNS and organs containing smooth muscle. The principal actions of therapeutic value are analgesia and sedation. Opioid analgesics also suppress…