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NIACIN NIACINAMIDE General Monograph, Nicotinic Acid, Vitamin B3 Nicotinamide Vitamin Action And Clinical Pharmacology: Niacin and niacinamide are water-soluble B complex vitamins. In vivo, niacin is converted to niacinamide, a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are coenzymes involved in glycogenolysis, tissue respiration and lipid metabolism. Niacin deficiency results in pellagra, a chronic wasting disease characterized by dermatitis, dementia and diarrhea. Niacin produces…

NIACIN SUSTAINED RELEASE Stanley Nicotinic Acid Vitamin Action And Clinical Pharmacology: Nicotinic acid, when released, is readily absorbed from the gastrointestinal tract following oral administration and widely distributed in the body fluids and tissues, even in the breast milk. The main route of metabolism in the liver is conversion first to nicotinamide then to N-methyl nicotinamide, the 2-pyridone and 4-pyridone derivatives and nicotinuric acid formed which are excreted in the…

NICODERM® Hoechst Marion Roussel Nicotine Smoking Cessation Aid Action And Clinical Pharmacology: Nicoderm is a multilayered rectangular film containing nicotine as the active ingredient. It provides 24 hour rate-controlled delivery of nicotine following its application to intact skin. Nicoderm reduces the withdrawal symptoms associated with smoking cessation and thus increases the success rate of smoking cessation programs. Indications And Clinical Uses: As an aid to smoking cessation for partial relief…

NETROMYCIN® Schering Netilmicin Sulfate Antibiotic Action And Clinical Pharmacology: Netilmicin is a semisynthetic, aminocyclitol, aminoglycoside antibiotic prepared from a dehydrogenated analog of gentamicin Cla. Netilmicin is a bactericidal antibiotic which acts by inhibiting normal protein synthesis in susceptible bacteria. It is thought to prevent amino acid polymerization by binding to the 30S ribosomal subunit. Netilmicin is rapidly and completely absorbed after i.m. administration. In adult subjects with normal renal function,…

NESACAINE®-CE Astra Chloroprocaine HCl Local Anesthetic Action And Clinical Pharmacology: Chloroprocaine stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthetic action. The onset of action is rapid (usually within 6 to 12 minutes). The duration of anesthesia depends on the procedure and the amount used, but could last up to 60 minutes. Chloroprocaine is rapidly hydrolyzed in plasma by pseudocholinesterase. This hydrolysis…

NEUPOGEN® Amgen Filgrastim Granulocyte Colony Stimulating Factor – Hematopoietic Agent Action And Clinical Pharmacology: Filgrastim is a human granulocyte colony stimulating factor (G-CSF) produced by recombinant DNA technology. G-CSF regulates the production of neutrophils within the bone marrow; endogenous G-CSF is a glycoprotein produced by monocytes, fibroblasts, and endothelial cells. G-CSF is a colony stimulating factor which has been shown to have minimal direct in vivo or in vitro effects…

NEULEPTIL® Rhône-Poulenc Rorer Pericyazine Psychotropic Agent Action And Clinical Pharmacology: Pericyazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects, and an action on the extrapyramidal system. Like other…

NERISALIC® Stiefel Diflucortolone Valerate – Salicylic Acid Topical Corticosteroid – Keratolytic Action And Clinical Pharmacology: Nerisalic combines the anti-inflammatory, antipruritic and vasoconstrictive activity of diflucortolone valerate and the keratolytic effects of salicylic acid. Both diflucortolone valerate and its split ester are topically active. Indications And Clinical Uses: The topical treatment of chronic eczema, psoriasis vulgaris, neuro-dermatitis and scaly crusty dermatoses which respond to corticosteroid therapy. Nerisalic is not suitable for…

NEO-MEDROL® Acne Lotion Pharmacia & Upjohn Methylprednisolone – Neomycin Compound Acne Therapy Indications And Clinical Uses: For control of acne vulgaris in the adolescent and young adult. Also in some cases of acne rosacea and seborrheic dermatitis. Contra-Indications: In tuberculosis of the skin, herpes simplex, vaccinia, varicella and in other cutaneous infections which do not respond to neomycin. Known hypersensitivity to any of the components. Precautions: Avoid contact with eyes….

NEO-CORTEF® Preparations Pharmacia & Upjohn Neomycin Sulfate – Hydrocortisone Acetate Antibiotic – Corticosteroid Indications And Clinical Uses: These preparations are indicated in the following conditions when threatened with or complicated by infection due to neomycin sensitive organisms. Eye Drops: phlyctenular kerato-conjunctivitis, nonspecific superficial keratitis, acne rosacea keratitis, allergic conjunctivitis, sclerokeratitis, episcleritis, traumatic keratitis. In generalized uveitis and inflammatory diseases of the posterior segment, systemic corticosteroid therapy should be employed. Ointment:…