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EURAX® Novartis Consumer Health Crotamiton Antipruritic Indications And Clinical Uses: To relieve itching in most types of dermatosis, notably: atopic dermatitis, chickenpox, contact dermatitis, creeping eruption, dermatitis herpetiformis, dermatitis medicamentosa, dermatophytosis, eczema, insect bites, intertrigo, lichen planus, neurodermatitis, neurotic excoriation, pityriasis rosea, poison ivy dermatitis, pruritus ani, scroti and vulvae, psoriasis, seborrheic dermatitis, senile pruritus, sunburn, urticaria, varicose eczema. Contra-Indications: Acutely inflamed skin or raw, weeping areas. Hypersensitivity to crotamiton….

EUFLEX® Schering Flutamide Nonsteroidal Antiandrogen Action And Clinical Pharmacology: Flutamide demonstrates potent antiandrogenic effects by inhibiting androgen uptake and/or inhibiting nuclear binding of androgen in target tissues. In adult male rats, ventral prostate weights and seminal vesicle weights were markedly reduced by daily administration of flutamide. Indications And Clinical Uses: For use in combination with LHRH agonistic analogues (such as leuprolide acetate) for the treatment of metastatic prostatic carcinoma (Stage…

ETHAMBUTOL HCl General Monograph Antimycobacterial Pharmacology: Ethambutol is a bacteriostatic agent which diffuses into actively growing mycobacterium cells such as tubercle bacilli, where it inhibits the synthesis of one or more essential metabolites, causing impairment of cell metabolism, arrest of multiplication, and cell death. It is active in vitro against strains of M. tuberculosis and other Mycobacterium species, but not other bacteria, fungi or viruses. Resistance develops rapidly if ethambutol…

ETHRANE® Zeneca Enflurane  Inhalation Anesthetic Action And Clinical Pharmacology: Enflurane is an inhalation anesthetic. Induction and recovery from anesthesia with enflurane are rapid. Enflurane does not appear to stimulate excessive salivation or tracheabronchial secretions, or affect bronchomotor tone. Pharyngeal and laryngeal reflexes are readily obtunded. The level of anesthesia changes rapidly, which would be predicted based upon its Oswald partition coefficients. Enflurane reduces ventilation as depth of anesthesia increases. This…

EPIVAL® EPIJECT® I.V. Abbott Divalproex Sodium Valproic Acid Anticonvulsant Action And Clinical Pharmacology: Divalproex has anticonvulsant properties, and is chemically related to valproic acid. Divalproex dissociates to the valproate ion in the gastrointestinal tract. Although its mechanism of action has not yet been established, it has been suggested that its activity in epilepsy is related to increased brain concentrations of gamma-aminobutyric acid (GABA). The effect on the neuronal membrane is…

ENTEX® LA Purdue Frederick Phenylpropanolamine HCI – Guaifenesin Decongestant – Expectorant Action And Clinical Pharmacology: Phenylpropanolamine is an alpha-adrenergic receptor agonist (sympathomimetic) which produces vasoconstriction by stimulating alpha-receptors within the mucosa of the respiratory tract. Clinically, phenylpropanolamine shrinks swollen mucous membranes, reduces tissue hyperemia, edema and nasal congestion, and increases nasal airway patency. Guaifenesin promotes lower respiratory tract drainage by thinning bronchial secretions, lubricates irritated respiratory tract membranes through increased…

ENTOCORT® Capsules Astra Budesonide Glucocorticosteroid for the Treatment of Crohn’s Disease Affecting the Ileum and/or Ascending Colon Action And Clinical Pharmacology: The active ingredient of Entocort capsules, budesonide, is a potent nonhalogenated synthetic glucocorticosteroid with high topical potency and weak systemic effects. The exact mechanism of action of glucocorticosteroids in the treatment of Crohn’s disease is not fully understood. Anti-inflammatory actions, such as the inhibition of inflammatory mediator release and…

ENTOCORT® Enema Astra Budesonide Glucocorticosteroid Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency. It undergoes an extensive degree (approximately 90%) of biotransformation in the liver to metabolites with low glucocorticosteroid activity. The glucocorticosteroid activity of the major metabolites, 6b-hydroxybudesonide and 16a-hydroxyprednisolone, is less than 1% of that of budesonide. The favorable separation between…

ENFALAC PREGESTIMIL® Mead Johnson Protein Hydrolysate Formula Pediatric Elemental Diet Indications And Clinical Uses: For feeding of infants and children with malabsorption problems which may include: disaccharidase deficiency (relative or absolute), idiopathic defects in digestion or absorption, steatorrhea, cystic fibrosis, food allergies and intestinal resection. Precautions: Patients with lengthy episodes of diarrhea and/or receiving antibiotics may require supplemental vitamin K. In a few instances, premature infants and infants with long-standing…

ENLON® Zeneca Edrophonium Chloride Nondepolarizing Neuromuscular Antagonist Action And Clinical Pharmacology: Edrophonium chloride is an anticholinesterase agent which antagonizes the action of nondepolarizing neuromuscular blocking drugs. Edrophonium chloride inactivates the enzyme acetylcholinesterase by combining with it in a reversible manner. The inactivation of the enzyme prevents the hydrolysis of acetylcholine and allows the accumulation of the neurotransmitter. The accumulation of acetylcholine at cholinergic receptor sites leads to the resumption of…